Endocrine Abstracts

Introduction: Acromegaly usually results from GH hypersecretion elaborated by somatotrop adenoma. The occurrence of a pregnancy in an acromegaly is an infrequent event, but better described in recent years. It could be aggravate GH secretion and tumor volume.Objective: Describe eight pregnancies including twin pregnancy in six acromegalics patients hospitalized in the endocrinology department of the Pierre and Marie Curie center in Algiers.<p class="...

Estradiol (E2), produced by granulosa cells (GCs) of ovarian follicles, plays an essential role in folliculogenesis by controlling follicular development and selection. E2 actions are principally mediated by the two nuclear receptors, ERα and ERβ. These two receptors are differently expressed in GCs, with ERβ being predominant. After ligand binding and receptor dimerization, ERα and ERβ mainly regulate gene transcription through direct interaction with...

Estradiol (E2) plays an essential role in woman fertility. E2, locally produced by granulosa cells (GCs) of ovarian antral follicles, controls follicular development and selection, and triggers the gonadotropin surge that leads to ovulation. Dysovulation arising from the arrest of antral follicle growth and maturation occurs in up to 10 % of reproductive-aged women suffering polycystic ovary syndrome (PCOS). Although the diagnostic criteria for PCOS are clearly established, th...

Polycyclic aromatic hydrocarbons (PAHs) are common environmental pollutants derived from the incomplete combustion of organic materials. In urban and industrial areas, level of pollution with these compounds is high, which leads to numerous negative health effects. Some literature data indicate the involvement of PAHs in the development of obesity, however, there is no data showing the distribution patterns of PAHs in human adipose tissue (AT) and their impact on the process o...

The immune microenvironment plays a central but ambivalent role in tumourigenesis. During initial phases of neoplasia, both innate and adaptive immune cells recognize and destroy tumour cells. However, during the process of immunoediting, tumour cells progressively reshape the microenvironment and use immune cells to favour neoangiogenesis, tumour growth and metastasis. Until recently, the role of immune response in the pathogenesis of ACC had remained elusive. Analysis of the...

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There is currently no curative treatment for metastatic phaeochromocytoma (PH) and paraganglioma (PG). Patient management aims at reducing tumor burden and preventing mechanical and secretory consequences of metastatic spread and must be adapted to disease progression. Focal treatments (surgery, radiofrequency ablation and embolization) reduce hypersecretion and facilitate subsequent systemic therapies using radionuclides (131I-MIBG, 177Lu- or 90Y-DOTATOC), chemotherapy (cyclo...

The adrenal cortex arises from the adrenogonadal primordium, which is also involved in the formation of the gonadal anlagen and is characterized by expression of the nuclear receptor Sf1. After individualisation, the adrenal primordium undergoes a series of developmental events that culminate with establishment of functional zonation, characterised by differentiation of zona glomerulosa and zona fasciculata. In the past 7 years, we have developed a number of mouse models recap...

White adipose tissue is a vital endocrine organ required for the storage of energy in the form of triglycerides, which is released in response to nutrient deprivation, and for the production of hormones such as leptin and adiponectin. In this way, adipose tissue is at the forefront of whole organism energy homeostasis. Adipose tissue dysfunction is associated with many metabolic diseases including T2D, cardiovascular disease and non-alcoholic fatty liver disease (NAFLD). Adipo...

During the past decades, advancement in onset of pubertal timing has been observed. Recent changes also include a trend towards delay in completion of puberty, raising the question of environmental influences. Since pubertal timing appears to be ‘programmed’ during foetal and neonatal life, factors such as endocrine disrupting chemicals (EDCs) could possibly interfere at those early stages. As an example, the insecticide DDT could partly account for the increased pre...