Endocrine Abstracts

Severe growth hormone (GH) deficiency in adults is associated with adverse changes in quality of life (QoL), body composition and cardiovascular risk profile. NICE guidance restricts GH replacement in the UK to those with impaired QoL, defined by a score of >11 in the QoL-AGHDA questionnaire.Aims: To assess whether the NICE guidance differentiates other clinical or biochemical features in GH deficient adults.Patients and...

Acromegaly is associated with increased morbidity and mortality. Surgery, radiotherapy (RT) and medical therapy are the treatment options to decrease GH and IGF-I concentrations to levels associated with cure or normalisation of mortality. We examined the response to dopamine agonists (DA) and somatostatin analogues (SSA) in 276 patients with acromegaly who received medical therapy during follow up (198 DA, 143 SSA). One hundred and seventy two had surgery and 73 RT prior to m...

Introduction: Bariatric surgery is currently considered the most effective treatment for morbid obesity, although rates of weight loss and comorbidities resolution differ among bariatric techniques and depending on preoperative factors.Objectives: In this study we analyse possible factors that influence the outcome of bariatric surgery (weight loss and improvement in metabolic comorbidities) in order to identify those patients most likely to benefit from...

Introduction: Bariatric surgery is currently considered the most effective treatment for morbid obesity. Laparoscopic gastric bypass (LGB) and laparoscopic sleeve gastrectomy (LSG) are the most widely used bariatric procedures today.Objectives: In this study we compared LGB and LSG in order to establish whether there is any superiority of one or the other in effectiveness and complications.Methods: We included all the patients who ...

The aim of treatment in patients with acromegaly is to achieve serum GH/ IGF-I concentrations associated with cure or normalisation of mortality. Using the West Midlands acromegaly database (n=501) we assessed a number of parameters in the follow up of patients with acromegaly including the reliability of basal fasting GH in predicting nadir or mean GH during oral glucose tolerance test (OGTT) or growth hormone day curve (GHDC) respectively, the degree of discordance be...

Context: Patients with hypopituitarism have increased morbidity and mortality. There is ongoing debate around the optimum glucocorticoid replacement therapy.Objective: To assess the effect of glucocorticoid replacement in hypopituitarism on corticosteroid metabolism and its impact on body composition.Design and patients: We assessed the urinary corticosteroid metabolite profile (using gas chromatography/mass spectrometry) and body ...

Acromegaly is associated with increased morbidity and mortality. There are several treatment options for acromegaly including surgery, radiotherapy and medical therapy. The aims of treatment in patients with acromegaly is to achieve GH and IGF-I concentrations associated with cure or normalisation of mortality.We examined predictive factors of response to treatment with dopamine agonists (DA) and somatostatin analogues (SSA) in a cohort of 501 patients w...

Acromegaly is associated with increased morbidity and premature mortality which has been demonstrated in a number of retrospective studies reporting a standardised mortality ratio (SMR) between 1.3 and 3. Many patients with acromegaly develop hypopituitarism as a result of the pituitary adenoma itself or surgery and/or radiotherapy. Hypopituitarism is also associated with an increased SMR (1.2–2.17).Using the West Midlands Acromegaly database (n<...

Background: Adrenocortical tumors (ACT) include benign and malignant forms. Adrenocortical carcinomas (ACC) are highly malignant neoplasms with poor prognosis and strong metastatic potential. Aurora kinase family members (AK) are serine/threonine kinase involved in the regulation of mitosis. Aurora kinase A (AKA) promotes centrosome maturation and spindle assembly, while aurora kinase B (AKB) is necessary for spindle assembly checkpoint and cytokinesis.A...

Introduction: We present the results of chemoembolization used as a locoregional treatment for liver metastases (on a transplanted liver) from a bronchial carcinoid neuroendocrine tumor with stage IV disease progression.Case report: A 60-year-old man diagnosed of bronchial carcinoid NET in 2002, underwent surgery by lung lobectomy and excision of lymph node metastases. Treated also with somatostatin analogues (SA) after subsequent discovery of liver meta...