Endocrine Abstracts

Introduction: The ghrelin gene products ghrelin and obestatin (Ob) protect mice from STZ-induced β-cell death, inflammation and STZ-induced diabetes. A possible event is ghrelin/Ob-induced regeneration of damaged β-cell population through the recruitment of pancreatic progenitor cells (PPC). We hypothesized that Ob affects proliferation and endocrine commitment of PPC within the islets of Langerhans.Methods: Islets of Langerhans were isolated f...

Obestatin (Ob) is a peptide recently identified as a product of the ghrelin gene. It was claimed to bind to the orphan receptor GPR39, but this finding is still a matter of debate. Ob exerts peripheral effects, for example, it promotes cell survival and has antiapoptotic actions in different cell lines. In addition, Ob has central effects, such as inhibition of thirst, modulation of anxiety, sleep and mnemonic functions. Mnemonic processes involve neurogenesis; in particular, ...

Cadmium (Cd) is a ubiquitously present toxic metal with an established ability to induce endocrine disruption, in literature often referred to as metalloestrogen. Some of the major uncertainties connected with endocrine disrupting chemicals (EDCs) in general, are low-dose exposure and the presence of nonmonotonic dose-response curves. This study aims to elucidate the presence of a dose-response relationship between the measured Cd levels in the tissue (internal dose) and estro...

Toxic metals can disrupt the endocrine system, harming the thyroid and male reproductive function, as indicated by epidemiological and experimental studies. A human biomonitoring study in Serbia determined the levels of toxic metals (Cd, Pb, As, Hg, Cr, and Ni) in the blood to identify real life scenario of exposure. On the basis of the metal measured levels, the doses for the oral 90 days treatment of male Wistar rats were calculated. The experiment included a control group a...

Pseudomonas aeruginosa mannose-sensitive-hemagglutinin (PA-MSHA) is a bacteria-mediated cancer therapy showing promise in inhibiting cancer growth by impeding tumor cells and inducing natural cell death. Clinical studies indicate its ability to enhance chemotherapy efficacy and stimulate the immune system against cancer, presenting manageable side effects such as fever and skin irritation. Nevertheless, the safety profile of PA-MSHA requires further exploration, emphasizing th...