Endocrine Abstracts

Objectives: Hürthle cell (oncocytic) lesions can be metaplastic or neoplastic events. The neoplastic entities -formerly, oncocytic variant of follicular tumours; Hürthle cell neoplasm (HCN) - include HC adenomas and HC carcinomas and have been recognized as a separate class of tumours by the WHO. The remaining of the thyroid tumours demonstrating “mitochondrion-rich cells” and oncocytic morphology are referred under the umbrella term of “oncocytic vari...

Objectives: Somatic copy number alterations (SCNAs) have been the most common genetic alterations identified in cancer, that frequently related with extensive genomic instability and to an aggressive behavior. Hürthle cell carcinoma is known to be aggressive, having the highest incidence of recurrences, distant metastasis and RAI therapy resistance among all differentiated follicular cell derived thyroid carcinomas. Due to these differences and recent molecular discoverie...

Introduction: Hypopituitarism is a rare entity that can have different aetiologies. Symptoms are usually progressive and non-specific; therefore, many patients are underdiagnosed and untreated. We present a clinical case of a patient presenting septic shock, hyponatremia and central hypothyroidism.Case report: A 46-year-old man was admitted in ICU for septic shock of unknown origin and multiorgan failure. Hormonal profile showed central hypothyroidism, p...

Infertility is a growing concern in Western countries. Several factors, including lifestyle habits and increased prevalence of chronic disorders associated with hormonal alterations, increased chronic inflammation and systemic oxidative stress (such as obesity and diabetes mellitus), are contributing to the reduction of reproductive potential among males in modern societies. Evidence suggests these factors negatively impact human sperm quality resulting in a combination of alt...

The aldosterone synthase (CYP11B2), being 93 % identical in its primary structure to CYP11B1, catalyses the 11beta-hydroxylation, 18-hydroxylation and 18-oxidation of deoxycorticosterone to form aldosterone. CYP11B2 is an important target for the development of drugs, since overproduction of aldosterone may lead to hypertension as well as heart failure. Thus, besides the mineralocorticoid receptor, CYP11B2 seems to be a potent target for drug development. To find specific inhi...

Rathke’s cleft cysts (RCCs) are benign epithelium-lined cystic remnants of the embryonic Rathke’s pouch. We report a case of a previously fit and well 30-year-old lady with an incidental finding of a cystic pituitary lesion, discovered when she took part in a clinical trial as a normal volunteer. She had no history to suggest endocrine dysfunction.Pituitary function tests showed prolactin 302 mU/l (ref <630), LH 2.2 U/l, FSH 4.9 U/l, oestra...

Rathke’s cleft cysts (RCCs) are benign epithelium-lined cystic remnants of the embryonic Rathke’s pouch. We report a case of a previously fit and well 30-year-old lady with an incidental finding of a cystic pituitary lesion, discovered when she took part in a clinical trial as a normal volunteer. She had no history to suggest endocrine dysfunction.Pituitary function tests showed prolactin 302 mU/l (ref <630), LH 2.2 U/l, FSH 4.9 U/l, oestra...

A 72-year-old man, otherwise fit and well, with treated hypertension presented to our hospital with abdominal pain and vomiting. He was febrile with deranged liver function tests and elevated inflammatory markers. Abdominal ultrasound showed a right suprarenal mass, and a normal gallbladder.CT confirmed a 37×31×24 mm right adrenal mass with no significant contrast enhancement, and bilateral pneumonia responsible for the septic picture. Thrombus...

We have shown that repeated cold stress increases ovarian sympathetic tonus and induces typical polycystic ovary syndrome (PCOS) features. Lesion of the noradrenergic nucleus Locus Coeruleus decreases ovarian noradrenaline release and prevents stress-induced PCOS in rats exposed to chronic intermittent cold stress. The aim of this study was to assess whether the alterations on ovarian morphology, ovulation rate and hormonal secretion induced by cold stress could be prevented b...

IntroductionPituitary apoplexy (PA) consists of acute infarction/hemorrhage of the gland, involving mostly a previously unrecognized adenoma. One of its most documented precipitating factors is anticoagulation in the context of acute coronary syndrome treatment. To our knowledge only one report described a PA secondary to anticoagulation for pulmonary thromboembolism.Case reportA 75-year-old men with known hy...