Endocrine Abstracts

Background: People with Diabetes (PwD) experience many obstacles in diabetes management including, but not limited to lack of motivation, limited knowledge on diabetes self-management and treatment adherence issues. Diabetes mandates regular follow-ups for good glycemic control and manage complications. Internet and smartphones, have revolutionized digital health and hence by employing digital health and technology, better outcomes may be achieved; which is realizable in India...

Background: As adoption of continuous glucose monitoring (CGM) continues to expand, lot more studies are investigating the effects of CGM on HbA1C and hypoglycaemia risks in people with Diabetes Mellitus (PwD). In PwD, established benefits of usage of CGM along with digital diabetes self-management and education (DSME) program in Indian real-world context are scarce. OneCare compares patients engaged in its “IMPACT’ DSME program alone vs program assisted by CGM.<...

Adrenocortical adenomas are among the most commonly identified human neoplasias, with a prevalence of 2-3% in the population. In some cases they are associated with autonomous cortisol excess that leads to increased morbidity and mortality. Altered cAMP/protein kinase A (PKA) signalling is common in sporadic cortisol-producing adenomas (CPA), mostly caused by somatic mutations in the genes coding for the catalytic subunit α of PKA (PRKACA) or the stimulatory G-pr...

Since earlier publications revealed a prominent and versatile impact of the neuromedin peptide family on several neuroendocrine processes, in the present experiments we focused on the effects of a recently discovered member of neuromedines, neuromedine S on such phenomena as open-field behaviour and hypothalamic-pituitary-adrenal (HPA) activation. The peptide was administered intracerebroventricularly to freely moving rats and 30 minutes later the aforementioned neuronedocrine...

Carney’s Triad is a rare syndrome, with fewer than 30 cases reported with all three tumors (Gastrointestinal stromal tumor, extra-adrenal paraganglioma and pulmonary chondroma) present, and less than 100 cases with two of the three tumor types.We report a 45 yr old female who presented with bloating, dizziness, sweating and palpitations. Physical examination was unremarkable. Biochemistry showed a normal hormonal profile, 24 hrs urinary catecholamin...

Introduction: Adrenal insufficiency is a common problem in our country due to steroid abuse in various forms. In many occasions the patients even do not know about its side effects and consequences of non-prescribed usage. Many of them presents with sudden withdrawal and adrenal crisis. Many of them admits in Gastroenterology unit due to vomiting, some of them in Medical unit with unexplained fever, weakness, anaemia, etc. Many of them having subtle features of Iatrogenic Cush...

Carney’s complex was first identified as the association of primary adrenal nodular dysplasia, lentigines and cardiac and skin myxomas. Several other endocrine and non-endocrine disorders were subsequently added to the complex, including pituitary tumors and melanotic Schwannomas. We herewith describe a kindred with Carney’s complex featuring acromegaly as the common denominator.Patients & methods: A 42-year-old woman first presented to our...

A 38-year-old woman with chronic autoimmune thyroiditis and hypothyroidism treated with levothyroxine (125 μg/day) was referred to our outpatient clinic with a history of sudden increase of goiter, weakness, dysphagia, dyspnea and suffocating sensation. Physical examination showed an enlarged, stony thyroid gland (three times of normal), without palpable cervical lymph nodes. Biochemical evaluation showed the following abnormalities: TSH 6.0 μU/ml (0.4–4.3), fre...

Objective: Remission of Cushing’s disease (CD) in the postoperative vary between 55–85%, recurrence of up to 25%. Remission and recurrence rates vary dependent on tumor size and neurosurgical expertise. The objective of this study is to describe whether there are clinical data that help us to predece recurrence of CD after transsphenoidal surgery (TSS).Patients and Methods: Retrospective analysis of patients who underwent as TSS for CD. Varia...

Objective: Cushing’s disease (CD) is difficult to diagnose because of its rarity and because its most common symptoms can overlap with those of other more common conditions. Remission rates in the postoperative vary between 55–85%. Overall, the mean time to diagnosis was 38 months. The objective of this study was to describe whether there is any pre-surgical clinical data that predicts CD remission after TSS.Patients and Methods: Retrospectiv...