Endocrine Abstracts

Background: SGLT-2 inhibitors (SGLT-2i) are used in treatment of type 2 diabetes mellitus (T2DM) through increasing urinary glucose secretion. Cases of euglycemic and hyperglycaemic diabetic ketoacidosis (DKA) have been reported in literature in patients using SGLT-2i. Increased glucose urinary excretion promoted by SGLT2i, decreases the production of insulin. In turn, lipolysis and ketone production increase predisposing the patient to developing DKA. It is hypothesised that ...

Congenital adrenal hyperplasia (CAH) is defined as several autosomal recessive diseases resulting from mutations of genes for enzymes mediating the biochemical steps of production of mineralocorticoids, glucocorticoids or sex steroids from cholesterol by the adrenal glands. Fertility in women with CAH is essential and underestimated clinical problem. According to current studies patients with classic form of CAH due to 21-hydroxylase deficiency have lower fertility rate that c...

Introduction: Recent data showed that PCOS is related to abnormal calcium and phosphate metabolism. The patients are characterized by elevated levels of PTH and decreased levels of vitamin D. Abnormalities in mineral homeostasis are related to insulin resistance. In this study, we assessed a complex of calcium and phosphate metabolism indices in patients diagnosed with PCOS.Material and methods: 60 women, aged 25±5 years diagnosed with PCOS accordin...

Background: Struma ovarii is a rare form of the ovarian germ cell tumors composed predominantly of mature thyroid tissue. It occurs mostly in the fifth decade. About 5–10% of these tumors are malignant. We present the case of a 20-year-old-woman with papillary thyroid carcinoma arising in struma ovarii.Case report: A 20-year-old woman presented to her gynecologist with pelvic pain. A right ovarian tumor was discovered at ultrasound examination. The ...