Endocrine Abstracts

Background: Effective management of adrenal insufficiency (AI) during sick day episodes requires adjusting oral glucocorticoid therapy or administering intramuscular injections to prevent adrenal crises. Given the critical nature of adrenal crisis management, educating families of young individuals with AI is essential.Aim: To critically appraise patient education concerning adrenal crisis management through a systematic...

Background: Effective management of adrenal insufficiency (AI) during sick day episodes involves adjusting oral glucocorticoid therapy or administering intramuscular injections to prevent adrenal crises. Therefore, educating families of young individuals with AI on emergency management is crucial.Aim: This study aims to critically evaluate online educational materials related to adrenal crisis management. We conducted a ...

Vitamin D deficiency and osteomalacia continue to cause significant morbidity in Bradford. Outpatient attendance suggests this condition remains widespread. Poor awareness of this preventable and treatable condition exists. This audit was undertaken to highlight the frequency of normal biochemistry in patients with osteomalacia / vitamin D deficiency. Fifty-five patients (4M, 51F; 51 Asian, 4 Caucasian) were identified from our departmental computerised endocrine database. 25-...

Introduction: Polycystic ovary syndrome (PCOS) is the most prevalent endocrine and metabolic disorder of women of reproductive age. Comprehensive metabolic profiling of women with PCOS across different ethnicities will help in understanding the pathophysiology of this condition.Methods: The Born in Bradford (BiB) study is a UK longitudinal birth cohort. Profiling of circulating lipids, fatty acids, and metabolites was do...

Background: The association between hypoglycaemia and CVEM is controversial. It is not ethical or practical to design RCTs to study this association as the primary clinical outcome measure. Therefore, utilization of epidemiological principles to study this association is essential.Objective: To systematically explore the data from MA, RCTs and OBS on hypoglycaemia and CVEM applying Bradford Hill criteria [strength, consistency, dose response or biologica...

Anna Spada is currently Full Professor at the School of Medice, University of Milan. Her main research interests are on signal transduction in pituitary cells, pathogenesis of pituitary tumors, genotype/phenotype relationships in acromegalic patients with gsp mutations, tissue specific GNAS1 gene imprinting, molecular mechanisms of resistance to hormone action, activating and inactivating mutations of GNAS1 in endocrine disorders, polymorphic variants of somatostatin receptor ...

There is a relative lack of data regarding the timing and in particular the severity of hypothyroidism post Radioiodine (RI). We retrospectively examined the timing and severity of hypothyroidism following RI in 213 patients, in relation to ‘target’ and actual follow up appointments, and the introduction of a nurse-led follow-up clinic. Hypothyroidism was defined as persistent elevation of TSH – mild (TSH 6.1–10 mU/l), moderate (TSH 10.1–50 mU/l) and s...

A 65-year-old gentleman was referred by his GP because of acute kidney injury and hypercalcaemia, which was associated with low levels of parathyroid hormone. He had been fit and well and was on no regular medications. Whilst his hypercalcaemia was partly correctible with saline rehydration, cautious use of bisphosphonates and cinacalcet were not effective in preventing rebound, and his nephropathy persisted. Curiously, he had longstanding low plasma alkaline phosphatase, but had normal denti...

Background: Radioiodine is an effective treatment for Graves’ hyperthyroidism. In most cases this therapy renders the patient completely hypothyroid. As a consequence they will require lifelong thyroid replacement therapy. Now it is controversial whether radioiodine should be given in a sufficient dose to induce hypothyroidism or a lower dose in an attempt to achieve a euthyroid state. Case Report: A 71-year-old woman with a 30 years history of Grav...

Steroid-dependent individuals, in particular those with primary adrenal insufficiency, are a vulnerable patient group. They are prone to acute adrenal crisis which is a life-threatening medical emergency requiring immediate recognition and treatment. Among individuals with primary adrenal insufficiency, acute adrenal crisis has a frequency of 6–8 per 100 patient-years. Unfortunately, delays in diagnosis and management are common, constituting an avoidable source of patien...