Endocrine Abstracts

Nodular Goiter Disease is very common, its prevalence varies between 26 and 67%. This rate is higher in iodine deficient regions. Recent data indicate that the incidence of both benign and malignant thyroid nodules is increasing. The most important factor in noduler guatr is iodine deficiency. The reported prevalence of nodular disease depends on which population is studied and the methods used to detect the nodules. There are other risk factors that lead to an increased incid...

Introduction: Hirsutism affects 5–8% of the whole female population. In most patients, hirsutism is associated with hyperandrogenemia and the most common cause of androgen excess is polycystic ovary syndrome; however, the clinical presentation of non-classical congenital adrenal hyperplasia(NCAH) in females is often indistinguishable from other hyperandrogenic disorders because of common clinical signs with hirsutism and poly cystic ovary syndrome(PCOS).<p class="abst...

Objective: Hirsutism, affects between 5% and 10% of women during reproductive age. Hirsutism associated with normal ovulatory function and normal circulating androgen concentrations is defined as idiopathic hirsutism and little information is available regarding the molecular pathogenesis.Aim: Significance of polymorphisms of the genes involved in androgen/oestrogen biosynthesis (SRD5A2,CYP19) and their expressions inmodulating the susceptibility ...

Although the existence of the interaction between sex steroids and immune system is well known, the mechanisms of this interaction are still unclear. Recently a second form of GnRH (GnRH-II) has been described in human, which is significantly expressed in immune tissues suggesting a potential function. In a recent in-vitro study it has been demonstrated that GnRH-II decreases local expression of IL-2R in peripheral lymphocytes (1). However in-vivo interactions of...