Endocrine Abstracts

Background: Ramadan is the religious month in which Muslims fast from pre-dawn (suhoor) until sunset (iftar), abstaining from all kinds of food, and liquid. The major change in meal times may be challenging for hypothyroid patients on levothyroxine because levothyroxine has a narrow therapeutic index and should be taken on an empty stomach.Objective: We aim to compare pre- and post-Ramadan Thyroid function tests of hypothyroid patients taking levothyroxi...

An established murine model of thyroid eye disease is induced by transfer of thyrotropin receptor (TSHR) primed T-cells to syngeneic recipients. Our aim was to extend the model to determine if: there are gender differences, Rundle's curve occurs and magnetic resonance imaging (MRI) could be applied as an in vivo marker. Orbital MRI on non-living mice used a surface coil and 1.5T MRI. 0.75mm slices have resolution sufficient to image ocular muscles. TSHR primed T-cells were gen...

Introduction: Despite Egypt being a sunny country (latitude 22–32°N) and enjoying a high year-round UV exposure (highest UV index in Cairo 12 in July and lowest 3 in December), it harbors a high prevalence of vitamin D deficiency especially in females (Botros et al, Endocrinol Nutr, 2015;62(7):314–321).Aim of work: We aimed to study a larger representative sample of Egyptian males and females, to identify the extent of the phenomenon and c...

Background: Topical corticosteroids (TCs) are widely used as depigmenting agents alone or in combination with other fairness creams. However, its use may cause secondary adrenocortical insufficiency.Objective: The aim of the present study is to evaluate the relationship between practice of whitening creams (Topical Corticosteroids) and serum cortisol level in a sample of healthy females at Ain- shams University hospital.Methods: We...

Introduction: Chemotherapy, as a systemic therapy, is one of the most effective modalities for cancer treatment. However, the use of chemotherapeutic drugs in patients with breast cancer can lead to thyroid dysfunction. The aim of our work is to determine the influence of adjuvant chemotherapy on thyroid function in female patients with breast cancer after radical mastectomy and before radiotherapy.Materials and methods: Our study was conducted on 40 Egy...

With the right balance of daily medication, individuals with adrenal insufficiency can expect to have a normal life span and to lead busy and rewarding lives. Despite this, research finds that people with adrenal insufficiency often feel below par compared to healthy individuals.(1)(2) One recent study found that the rate of hospital admission for adrenal crisis is almost three times higher for women with autoimmune adrenalitis than it is for patients with secondary adrenal in...

Background: Dysmetabolic iron overload syndrome (DIOS) is characterized by elevated ferritin and normal transferrin saturation level. Iron metabolism may be linked to the sympathetic overactity. DIOS is seen in 15–20% of the metabolic syndrome cases.Aim: This study aimed to test the hypothesis linking the increased baseline sympathetic drive to the hypertension seen in dysmetablolic iron overload syndrome in cases of metabolic syndrome.<p class=...

Type 1 diabetes mellitus (DM) is a multi system disease with both biochemical and anatomic/structural consequences. A number of components of the metabolic syndrome may be observed in patients with type 1 diabetes. It was suggested that treating obese adolescents with insulin resistance using metformin is an option for patients without response to traditional lifestyle change. It was reported that fetuin-A could inhibit insulin receptor tyrosine kinase activity and induced a l...

Background: 22q11.2 deletion syndrome (22q11DS) displays a wide phenotypic spectrum and is the most common deletion syndrome with an estimated incidence of one in 4000 children. Short stature is a phenotypic feature of the spectrum; uncommonly, GH deficiency (GHD) has been identified as a cause of short stature within this population.Patients and methods: We describe a case series of four 22q11DS patients with concurrent GHD that have been followed up in...

A 37-years-old man was referred to rheumatology with a 3 month history of widespread joint pains, worse on rising in the mornings with early morning stiffness lasting about 15 min. Hands were affected first followed by knees and hips. On further questioning, he also complained of generalised fatigue, loss of libido and thinning of the hair on his chest, as well as 15 kg weight loss over 6 months. He recalled a febrile illness with headache prior to the onset of his symptoms, b...