Endocrine Abstracts

Background: Adolescence is a challenging time for people with type 1 diabetes (T1DM), associated with worsening glycaemia and disengagement with care. Educational interventions often focus on imparting diabetes-specific skills rather than attending to some of the broader psychosocial challenges young people commonly experience. To address this, we codesigned a psychosocially modelled programme of diabetes education, named ‘Youth Empowerment Skills’ (YES), with young ...

Beckwith–Wiedemann syndrome (BWS) is an overgrowth syndrome caused by multiple epigenetic and genetic changes. It is due to genetic and epigenetic mechanisms affecting the balance of imprinted genes on chromosome 11p15.5. This region has two imprinted control regions, ICR1 and ICR2. ICR1 contains the genes H19 and IGF2 genes with H19 being maternally expressed and IGF2 paternally expressed. ICR2 contains the KCNQ1, KCNQ1OT1, and CDKN1C genes. Hypomethylation of KvDMR1 (an...

THE SENSITIVITY OF 123I-MIBG IN THE DETECTION OF HISTOLOGICALLY CONFIRMED CATECHOLAMINE-PRODUCING TUMOURS.M Ismail, R Foley, WM Drake, AB Grossman, PJ Jenkins, SL Chew, GMBesser, R Reznek, K Britton, JP MonsonDepartments of Endocrinology, Nuclear Medicine and Radiology, StBartholomew's Hospital (QMUL), London EC1A 7BERadionuclide imaging is widely used for the loc...

Introduction: hypothyroidism is among the most frequent causes of infertility, our objective is to analyze this population in order to evaluate the effectiveness of treatment with levothyroxine.Patients and methods: this is a retrospective interventional study from September 2017 to September 2022.Inclusion criteria: infertility, TSH>2.5 mmol/lExclusion criteria: infertility for less than 1 year, age ≥ ...

Introduction: In diabetology all the recommendations insist on the intensification of the antidiabetic treatment with the maintenance of the same treatment if the type 2 diabetes mellitus is balanced. Our work insists on dietary treatment and focuses on weight loss in order to degress antidiabetic treatment until cessation.Patients and methods: This is a prospective interventional study. Type 2 diabetes mellitus on pharmacological treatment: treatment is...

Background: International Diabetes Federation (IDF), in collaboration with the Diabetes and Ramadan (DAR) International Alliance proposed in 2021, IDF-DAR Practical Guidelines with a score that allows certain patients even on insulin to fast which requires regular and appropriate blood glucose monitoring.Aim: Develop a special Ramadan blood glucose self-monitoring table in order to limit the risk of acute compilations during this month.<p class="abst...

Introduction: The EMPA-REG OUTCOME is a cardiovascular safety study with empaglifozin that has shown a reduction in cardiovascular mortality and a decrease in hospitalization for heart failure. Our work is based on the analysis of the protocol that recognized five changes, the last, 3 years after the start of the study and which affects the definitions of the elements of the primary composite, and following these modifications, we find that the mortality Cardiovascular was inc...

IAS is common in Japanese but rare in Caucasians. Highlighting its aetiology is paramount in understanding its clinical and analytical variabilities and can help planning investigations and avoid mistakes in the interpretation of false pancreatic endocrine data commonly associated with this syndrome.The underlying aetiology of IAS is the presence of high affinity/avidity endogenous insulin autoantibodies in significant amounts in non-diabetics. Clinicall...

40years old lady with 12 months history of hyperthyroidism. Treated with ATD. Referred by her treating physician for RAI therapy due to intolerance to ATD and high dose requirement after 12 months. Patient being treated as Classical Graves’ Hyperthyroidism. She had symptoms of hyperthyroidism at time of presentation but none at time of assessment in our hospital. Main current issue was painful neck swelling: developed slowly over preceding two months. No problems with swa...

Congenital Adrenal Hyperplasia is a group of autosomal recessive disorders characterised by enzyme defects in the steroidogenic pathways involved in the biosynthesis of cortisol, aldosterone and androgens. 21-hydroxylase deficiency accounts for more than 90% of cases.Case history: 41-yr-old female was referred to Endocrinology with a serum testosterone of 14.3 nmol/l (0.20–2.86). She was a full term baby born to non...