Endocrine Abstracts

Backgrounds: Based on anthropometry and blood biochemical tests, this study aims to analyze the variation of glucose and lipid metabolism in Cushing’s syndrome (CS) patients caused by adrenal adenoma combining with flash glucose monitoring system (FGMS) and dual-energy X-ray absorptiometry (DEXA).Methods: According to the strict diagnostic and exclusion criteria, seven healthy controls (HCs) and seven CS patients were collected in this study. First,...

BackgroundsThe study aimed to explore the characteristics of glucolipid metabolism in patients with nonfunctional adrenal incidentaloma(NFAI). And investigate the relationship between these factors and insulin resistance, islet beta cell function.MethodsThis study enrolled eight patients with nonfunctional adrenal incidentaloma and five healthy controls(HCs). These data were recorded including body measuremen...

BackgroundHormone replacement therapy is often used for hypopituitarism, which leads to dysglycemia. This study is conducted to assess the glucose metabolism conditions using the flash glucose monitoring system (FGMS) in patients with hormone replacement therapy.MethodSeven patients who were diagnosed as hypopituitarism and treated with glucocorticoids and L-Thyroxine were qualified to participate in this stu...

Objectives: We previously reported the outcome of 1-year follow-up of 2013 DTC patients in the DTCC (differentiated thyroid cancer in China) 1st stage Study. Using the retrospectively gathered information, we sought to observe the long-term follow-up and prognosis of these patients with DTC undergoing thyroid surgery.Methods: This multicenter, noninterventional study was conducted at eight tertiary hospitals across China. Data from the patient...

We previously reported that calycosin, a natural phytoestrogen structurally similar to estrogen, successfully triggered apoptosis of ER-positive breast cancer cell line, MCF-7. To better understand the antitumor activities of calycosin against breast cancer, besides MCF-7 cells, another ER-positive cell line T-47D was analyzed here, with ER-negative cell lines (MDA-231 and MDA-435) as control. Notably, calycosin led to inhibited cell viability and apoptosis only in ER-positive...

Orexins, acting via their receptors, are involved in the control of feeding, sleep-wakefulness, arousal, neuroendocrine homeostasis and autonomic regulation. However, the 5′ structure and regulation of human orexin type 2 receptor (OX2R) gene remains is not known. We present original findings regarding the 5′ structural organization of the human OX2R gene and identify four OX2R mRNA transcripts that differ in their 5′-untranslated region (UTR). The four trans...

Orexins, acting via their receptors, are involved in the control of feeding, sleep-wakefulness, arousal, neuroendocrine homeostasis and autonomic regulation. However, the 5′ structure and regulation of human orexin type 2 receptor (OX2R) gene remains is not known. We present original findings regarding the 5′ structural organization of the human OX2R gene and identify four OX2R mRNA transcripts that differ in their 5′-untranslated region (UTR). The four trans...

ImportanceThere remains uncertainty about the impact of menopausal hormone therapy (MHT) on women’s health. A systematic, comprehensive assessment of the effects on multiple outcomes is lacking.ObjectiveTo comprehensively summarize evidence on the benefits and harms of MHT across diverse health outcomes in women.Data sourcesMEDLINE, EMBASE and 10 other databa...

Chronic inflammatory disease is often accompanied by angiogenesis and fibrosis. Glucocorticoids (GCs) exert anti-inflammatory and anti-angiogenic effects, in which macrophages are a major target. Local endogenous GC action is controlled by 11β-hydroxysteroid dehydrogenase (11β-HSD), with the type 1 isozyme, 11β-HSD1 converting inactive GCs into active forms. Mice deficient in 11β-HSD1 have a phenotype consistent with reduced glucocorticoid action, including...

Background and objective: Children with chronic kidney disease (CKD) have impaired growth that leads to short stature in adulthood and treatment with recombinant human growth hormone (rhGH) is associated with improved growth. This study aimed to evaluate the efficacy and safety of daily rhGH (Jintropin®) in children in China with growth failure caused by CKD prior to transplantation.Methods: Prepubertal patients (2–13 years old) with CKD-relate...