Endocrine Abstracts

Introduction: According to the results of several studies and meta-analyses, certain ultrasound features are associated with increased risk of thyroid malignancy. However, most of those research papers included mainly papillary thyroid cancers (PTCs); these results cannot be simply extrapolated for the differentiation of follicular thyroid adenomas and cancers (FTAs and FTCs). The aim of the present study was to perform a meta-analysis of so far conducted research and identify...

Introduction: Iodine deficiency in Western countries is considered a historic disease. In 1924 up to 30% of school aged children in the UK had a goitre. The UK however remains one of the most iodine deplete countries in the world. Those following restricted diets are also at particular risk of iodine deficiency.Case Report: A nine year old female on a significantly restricted diet due to multiple food allergies presented with a goitre. Ultrasound scan co...

Introduction: The common causes of thyrotoxicosis are Graves’ disease, toxic multinodular goitre and toxic adenoma which account for >90% of cases of this condition. Iodine-induced thyrotoxicosis (Jod-Basedow syndrome) is infrequently considered as a cause of thyrotoxicosis. This case describes a lesser known cause of iodinated contrast-induced thyrotoxicosis.Case Report: A 47 year old man with known alcoholic liver disease and recurrent pancrea...

Preoperative preparation of the hyperthyroid patient for thyroidectomy is imperative to avoid perioperative complications due to severe thyrotoxicosis. 24-years old woman was admitted at our clinic for uncontrolled Graves’ disease. In our case, agranulocytosis introduced by propylthiouracil. Therefore, surgery was the only chance of an effective therapy. In cases when the patient is unresponsive to medical therapy or when such therapy is contraindicated, therapeutic plasm...

Introduction: Graves’s disease is an autoimmune condition both cell and antibody-mediated, which is associated with thyrotoxicosis and extra thyroid features.Case report: A 35-year-old female presented with symptomatic hyperthyroidism due to graves thyrotoxicosis. She developed adverse reactions, including severe dermatitis and hepatotoxicity, to two of the thionamide drugs (carbimazole and propylthiouracil). Eventually we decided for definitive tre...

A 35-year lady with Grave’s disease and brittle asthma presented to the Endocrinology team with symptoms and signs of thyrotoxic crisis. She was not on any anti-thyroid medication as she had previous suffered a severe rash in response to carbimazole, and profound gastrointestinal disturbance with propylthiouracil. It was suggested that she consider radioiodine to control her condition, but as a single parent with young children she was not prepared to undergo the isolatio...

Over recent years, the numbers of commercially available slimming aids have increased dramatically. Whilst the majority of these aids are harmless, their interaction with normal physiology is either not understood or not brought to the attention of the customer. We report the case of a 45-year-old woman who presented with clinical and biochemical thyrotoxicosis (fT4 31.5 pmol/l, fT3 14.3 pmol/l, TSH <0.02 mIU/l). She had elevated TPO antibodies (51 IU...

Introduction: In thyrotoxicosis, the clinical syndrome of excess circulating thyroid hormones, differentiation must be made between thyrotoxicosis with increased or decreased radio-iodine tracer uptake on thyroid scintigraphy. A cause of thyrotoxicosis with decreased radio-iodine uptake is iodine excess. In patients not taking any medication and without any history of recent radiological imaging studies, the confirmation of iodine excess as the cause of the thyrotoxicosis is d...

Background: Thyroid storm is an extreme disorder that occurs in case of severe thyrotoxicosis. This is a life-threatening condition with mortality rates up to 10–20%. A typical dose of iodinated contrast media (ICM) contains approximately 13.500 µg of free iodide and 15 to 60 g of bound iodine, which represents an acute iodide load of 90 to several hundred thousand times the recommended daily intake of 150 µg. As a result of sudden exposure to high iodide loads...

Introduction: Amiodarone is a well-established class III antiarrhythmic drug used in the treatment of arrhythmias and atrial fibrillation.Case report: HistoryA 68 year old gentleman who has background history of persistent Atrial fibrillation, dilated cardiomyopathy, took digoxin 125 mg, bisoprolol 2.5 mg and warfarin 2 mg, simvastatin 40 mg, Ramipril 10 mg. Digoxin was discontinued due to the nocturnal pauses, bradycardia on 24 ho...