Endocrine Abstracts

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects reproductive age women and predispose to the development of metabolic disturbances. However, Rotterdam criteria, commonly used to diagnose and classify this disorder, do not include metabolic markers. Recent research has shown that several metabolic factors may play a role in PCOS pathogenesis. Branched-chain amino acids (BCAA) are the group of essential amino acids including leucine, isol...

Objective: Sperm cells are produced in the testes by the Sertoli cells. These cells produce Inhibin B too and they are stimulated by FSH. Can Inhibin B be a good marker of spermatogenesis? Should we use other marker (FSH?, testosterone?)Design: Prospective study.Patients: We examined 56 patients with infertility.Methods: Semen analysis and hormonal analysis was performed. Semen analysis was performed accordin...

CHEK2, located on chromosome 22q, is a tumor suppressor gene. Its’ pathogenic variants are often associated with a tumor predisposition syndrome 4, with an increased risk of breast, prostate and colorectal cancers. There are some reports of an increased risk of papillary thyroid cancer (PTC) in carriers of the CHEK2 pathogenic variants. Current guidelines, however, do not recommend general screening of TC patients. The study assessed the prevalence of pa...

A 66-year-old patient was diagnosed with lung cancer. In the interview, smoking for 40 years, about 20 cigarettes/day. Due to the intensifying cough, an x-ray of the chest was performed, a large tumor (12 cm) of the mediastinum and the right cavity was found. In the histopathological examination squamous cell carcinoma. Stage T4 N2 M0. Due to tumor inoperability, the patient was qualified for sequential chemo-radiotherapy. He received 3 cycles of chemotherapy (navelbin and cis...

The aim of the study was to determine mRNA expression of genes involved in steroidogenic pathways in chicken ovarian follicles by real-time PCR method.Hy-Line Brown hens (n=20), 28 weeks of age, laying regular sequences of about 20 or more eggs per clutch were used in the experiment. Birds were decapitated ~2 h after ovulation. From the ovary, white prehierarchical follicles (1–8 mm) and the three largest yellow preovulatory follicles F3&#150...

Introduction: Hyponatremia can be a life-threatening emergency. Severe hyponatremia may occur in patients with hypopituitarism and secondary adrenal insufficiency and hypothyroidism. The acute decompensation of pituitary insufficiency can also lead to accompanying rhabdomyolysis and acute renal failure (ARF).Case report: A 67-year-old woman complaining of general fatigue, dizziness, nausea, feeling cold and numbness of limbs and tongue was admitted to th...

Introduction: Rapid deterioration of health condition in patient with diagnosed neoplastic disease, especially metastatic one, requires consideration of cancer progression. However other rare severe complications can occur. In 0.6–0.7% patients with medullary thyroid cancer (MTC) the ectopic ACTH syndrome (EAS) is observed. Hereby, we present a case EAS in patient suffered from MTC.Case report: A 37-year-old man was admitted to the Department of Int...

Objective: Sperm cells are produced in the testes by the Sertoli cells. These cells produce Inhibin B and they are stimulated by FSH. Can Inhibin B be a good marker of spermatogenesis? Should we use other marker (FSH?, testosterone?)Design: Prospective study.Patients: We examined 71 patients with infertility.Methods: Semen analysis and hormonal analysis was performed. Semen analysis was performed according to...

3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase (HSD3B) is a key enzyme catalyzing an essential step in the formation of all classes of steroid hormones. Previously, we have reported the presence of androgen receptors in the fetal porcine gonads denoting the role of androgens during gonadal development. There is also growing evidence that steroid hormones modulate HSD3B expression. Thus, the aim of the present study was to determine the effect of androgen defici...

Introduction: Pheochromocytoma is usually benign neuroendocrine tumor arising from chromaffin cells. Malignant tumors which account for 5–26% mainly metastize to bones, lungs, liver, but very rarely to brain. The coexistence of pheochromocytoma with brain meningioma may hinder the diagnosis.Aim: The aim of this study is to present the case of a malignant pheochromocytoma female with brain metastases and coexisting meningioma.C...