Endocrine Abstracts

Introduction: Hybrid closed-loop system (HCS) in Type 1 diabetes (T1D) management uses an automated algorithm to adjust basal insulin and administer correction doses to maintain glucose homeostasis. We have more children with HbA1c <58 mmol/mol. We aim to investigate if HCS contributed to this improvement.Methods: We identified TID children who started on HCS in our hospital from the year 2019–2023. Our HCS are ...

Background: Bilateral cataracts are rarely the initial symptom of diabetes mellitus (DM). Patients with DM who developed cataracts usually have DM for many years. The prevalence of early cataracts in paediatric DM ranges between 0.7 and 3.4%. We report a case of DM diagnosis following onset of blindness due to new bilateral cataracts.Case description: 13-year-old Caucasian girl presented with rapidly declining vision for 2 months. She was blind 2 weeks p...

Objectives: The TNM classification is a worldwide benchmark for reporting the extent of malignant disease and is intended as a prognostic tool to predict the outcome in patients with cancer. Until 2004, no TNM classification was available for adrenocortical carcinoma (ACC) and different staging systems were used. Due to the rarity of this malignancy, the prognostic value of different staging systems has never been compared directly in a large series of patients.<p class="a...

Introduction: We describe a novel case of familial congenital aniridia in a Caucasian woman with associated insulin requiring diabetes mellitus. This human combination has been described in Asian families in association with a heterozygous Paired Box 6 (PAX6) mutation (1) with subsequent evidence supporting that the mutation in this transcription factor causes decreased Proconvertase 1/3 function in the pancreas and a high proinsulin to insulin ratio (2). Our case does not hav...

Perfluorooctanesulfonate (PFOS) and its related product perfluorooctanic acid (PFOA) are anthropogenic fluorosurfactants widely used in consumer products. In general, studies in rodents have supported the conception that PFOS perturbs testis function, such as by inducing Sertoli cell injury. It remains to be demonstrated if similar effects could be reproduced in humans. We sought to examine its effects on human spermatogenesis by using a human Sertoli cell primary culture syst...

Type 1 diabetes mellitus (T1DM) not only is congenital disease that known as insulin-dependent diabetes, often occurs in children and adolescents. Recent advances in quantitative proteomics including fluorescence two-dimensional differential gel electrophoresis (2D-DIGE) and matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) have offered opportunities to discover plasma proteins as biomarkers for tracking the progression and for underst...

Introduction: Panhypopituitarism is a known but rare presentation of lymphoproliferative disease. We describe a patient with newly diagnosed advanced diffuse large B-cell lymphoma who presented with anterior hypopituitarism and concomitant adrenal gland involvement.Case report: A 72 year-old Chinese woman presented with a few weeks’ duration of lethargy, weight loss and functional decline. A hormonal screen done at admission suggested central hypoth...

Introduction: Hypogonadism is known to persist after treatment of hyperprolactinemia, necessitating androgen therapy in young male patients. Aromatisation of testosterone to estradiol can result in tumor expansion. We report a patient with persistent hypogonadism post treatment of macroprolactinoma and discuss challenges involved in the management.Case report: A 51-year-old gentleman was admitted for streptococcal meningitis. Brain imaging revealed a pit...

Introduction: Male hypogonadism secondary to AIDS is common and may present with non specific symptoms. Patients may self-diagnose hypogonadism and seek unauthorised androgen therapy. We report a male patient who developed polycythemia after receiving unauthorised sources of androgen therapy.Case report: A 42 years old man with AIDS diagnosed 10 years ago has repeatedly refused antiretroviral therapy. His most recent CD4 count was 314 cells/μl. His ...

Background: Bariatric surgery has been shown to decrease insulin requirements even before significant weight loss has occurred. We report a patient with marked improvement in glycemic control despite modest weight loss post bariatric surgery.Case presentation: A 47 years old Chinese man with obesity (weight 90 kg, BMI 31.2), hypertension, hyperlipidemia and type 2 diabetes mellitus diagnosed in 2005 is on follow up with our endocrine clinic. Despite comp...