Endocrine Abstracts

Introduction: Alcohol use disorder AUD causes high socio-economic costs and has a detrimental impact on health globally, being considered a key risk factor for non-communicable diseases. In Switzerland, four substances are currently approved for treatment of AUD, with varying effects. Taking into consideration the complex nature of the disease and the heterogeneity of affect patients, it becomes evident that there is need for new treatment targets. A body of preclinical studie...

Background: Research indicates that prolactin, a hormone linked to lactation, may influence the brain’s reward system by interacting with dopamine. GLP-1 analogues, prescribed for diabetes and obesity, are known for their appetite-suppressant effects. With GLP-1 receptors found in mood and reward-related brain regions, a potential role of GLP-1 in reward regulation is suggested. A knowledge gap exists regarding the interaction between GLP-1 and prolactin in the context of...

Background: GLP-1 analogs are prescribed for diabetes and obesity due to their well-known insulinotropic, satiation-promoting and appetite-suppressant effects. Several studies also investigated the effects of GLP-1 analogs on reward to addictive drugs such as alcohol, nicotine and cocaine. Pre-clinical studies suggest that sexual desire, as another type of natural reward, could also be affected by GLP-1 analogs. Since sexuality is a very important aspect of human wellbeing and...

A 29-year-old pregnant lady known hypothyroid for 5 years, presented with thyroid eye disease (TED). She is a non-smoker. Her TFT in the past years has been stable.Her exophthalmos was noticed at early pregnancy. Her anti-thyroid peroxidise antibodies (TPO-Ab) were >1300 mU/l (ref. range <1.4) and TSH-R antibodies (TRAB) were 18.6 U/l (ref. range <5.0).On presentation she was clinically and biochemically euthyroid with ...

Introduction: Papillary thyroid carcinoma is characterized by a good prognosis and a slow progression. Its metastases are usually located in cervical lymph nodes. But, sometimes they can reach the lung and bones. Cerebral metastases are exceptional as they have been reported in only 4%. Single or multiple, they can be totally symptomatic, but they are life threatening and require specific care as in the following caseCase report: A man aged 56, was refer...

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Introduction: Isolated central hypothyroidism is a rare disease. Acquired causes for central hypothyroidism include iatrogenic, traumatic, immunologic, infiltrative, infectious, vascular or space-occupying lesions. Empty sella may present with endocrine dysfunction, mainly hyperprolactinemia and growth hormone or gonadotropin deficiency. Few cases of empty sella associated with isolated TSH deficiency were published.Case report: A 66-years-old female wit...

Patients diagnosed with Addison’s disease and diabetes mellitus type1, has a rare combination of two autoimmune conditions. Two diagnosis that requires a great deal of self-care. Patients have a potential risk to induce endocrine emergencies such as diabetic hypoglycemia, adrenal crisis and diabetic ketoacidosis. The lack of lifesaving hormones can put the patient in potential life threatening situations. I’ll share my experience in meeting these patients. Brief phys...

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Research activities such as patient recruitment and data collection for audits and clinical trials led by physicians are common routine practice for a lot of endocrine specialist nurses, however a small percentage of them undertake independent research. Nurses are in a great position of getting research ideas of the ground that can translate back into practice and make a real difference to patient care.The aim of this presentation is to give practical ad...