Endocrine Abstracts

Craniopharyngiomas (CP) are congenital, benign, embryonic malformations which arise from ectoblastic remnants of Rathke’s pouch and are located in the (supra-)sellar region. Many patients show a reduced growth rate and an increased BMI early before the diagnosis of CP. However, it is unknown whether patients with CP present with increased head circumference before diagnosis. A cohort of 90 patients was screened for medical records of their developmental monitoring visits....

Introduction: Diabetic Ketoacidosis (DKA) is a medical emergency and major cause of mortality in children with type 1 diabetes (T1D). Careful evaluation is needed to identify expected and more unusual complications of DKA.Case report: A 16 year old male with poorly controlled T1D presented with severe DKA; he reported excessive vomiting and had severe abdominal pain. He informed taking ‘Ecstasy’ (3,4-methylenedioxymethamphetamine; MDMA) twice i...

Immortalized human thyroid follicular epithelial cell lines represent a valuable tool for the investigation of thyroid physiology in vitro. While there is an extensive selection of human thyroid carcinoma cell lines, the number of healthy follicular epithelial cell lines is limited. The vast majority of studies on thyroid physiology is based on the human immortalized cell line Nthy-ori 3-1, leading to comprehensive characterization of this cell line. However, in 2021 ...

Background: Sex differences in clinical picture of ACTH-dependent Cushing’s syndrome are controversial, except for the known higher prevalence in females. We compared a broad range of potential differences to enable a more accurate understanding of the clinical picture of sex-specific ACTH-dependent Cushing’s syndrome.Design: Cohort study.Methods: We included consecutive patients with ACTH-dependent Cushing’s syndrom...

Background: Adrenal crisis, the most feared complication of adrenal insufficiency, is a potentially life-threatening situation of acute glucocorticoid deficiency. After successful surgery, many patients with Cushing’s syndrome develop (transient) adrenal insufficiency. The incidence of adrenal crisis in patients treated for hypercortisolism is unknown.Methods: Cohort study including consecutive patients with Cushing’s syndrome with adrenal insu...

The increasing prevalence of obesity is paralleled by related metabolic disorders such as insulin resistance and type 2 diabetes mellitus (T2DM). Extensive efforts across disciplines are made to reveal underlying mechanisms and develop effective therapies against obesity and its comorbidities. Since PET–CT studies provided evidence for functional brown adipose tissue (BAT) in adult humans, this specialized thermogenic compartment of adipocytes is in the focus of current r...

Adrenocortical carcinoma (ACC) is part of the Li-Fraumeni tumour syndrome which is due to germline mutations in TP53. Recent studies demonstrate low penetrance mutations leading to later tumour manifestation. Furthermore, in ACC mutations outside the hotspot region have been found. TP53-polymorphisms have also been described to impact on p53 function. We, therefore investigated TP53 sequence alterations in a large cohort of adult patients with ACC.Method...

Objective: Gestational thyroid dysfunction and gestational diabetes mellitus (GDM) are common complications during pregnancy and often co-occur. Since thyroid hormones increase glucose uptake and insulin sensitivity, it has been hypothesized that hypothyroidism might increase the risk of GDM. Our aim was to study if maternal thyroid function test abnormalities are risk factors for GDM.Methods: A systematic search of Ovid MEDLINE, EMBASE and Web of Scienc...

Objective: Adequate thyroid hormone availability is essential for foetal neurodevelopment. While overt maternal hypothyroidism is associated with lower offspring IQ, recent studies suggested an inverse U-shaped association, with suboptimal offspring neurodevelopment for both the lower and higher thyroid function range. Our aim is to investigate the association of gestational thyroid function with offspring IQ scores, assess if this association is different based on the gestati...

Journal of Endocrinology, 2021, 248(1): 75-86 (DOI: https://doi.org/doi.org/10.1530/JOE-20-0404)...