Endocrine Abstracts

Background: Papillary thyroid microcarcinoma (PTMC) is a papillary thyroid cancer (PTC) type with a maximum diameter of ≤ 10 mm. Generally, PTMCs have good prognosis and low mortality risk. However, there are cases of PTMCs showing more biologically aggressive characteristics, such as lymph node (LN) involvement and distant metastasis.Objectives: Reveal the factors affecting the prognosis and aggressiveness of PTMCs.Methods: ...

Introduction: Papillary thyroid microcarcinomas (PTMC) are usually detected incidentally. They occur as a result of histological/microscopic examination of a thyroid removed especially for nodular goiter. Generally, the prognosis is good. However, it has been reported that lymph node (LN) metastasis is more common especially in PTMCs with tumor size > 5mm. In this study, it was aimed to show the effect of tumor size on prognosis by comparing clinicopathological data in pat...

Introduction: The issue of autoimmune thyroiditis (AIT) today is topical for modern endocrinology both due to the relatively high incidence among the population and the large number of organs and systems involved in the pathological process as a result of loss of the thyroid gland hormone-producing function and a decrease in thyroid hormone levels in the blood.Aim: The aim of the research is to study the state of the processes of lipid peroxidation and e...

Intracranial germ cell tumors (GCTs) account for only 0.4–3.4% of all central nervous system (CNS) tumors. A 18 year old patient with an unremarkable medical history was presented to the ophtalmology outpatient clinic with a 2 month history of loss of vision at left eye and blurrred vision at right also headache and fatigue. Ophtalmological examination showed loss of visual acuity at left eye and decreased 0.05–0.1 at the right and bilateral optic atrophy. Further ph...

Introduction: The aldosterone-to-renin ratio (A/R) is the most frequently used screening test for primary hyperaldosteronism (PH) and a confirmation test is recommended when it is high. We aimed to determine the frequency of PH in patients with high A/R and investigated possible clinical features that might help to prevent unnecesary confirmation tests.Method: Patients who underwent saline infusion test because of high A/R (>3.8) were retrospectively...

Pheochromocytomas and paragangliomas are rare but life threatening tumors secreting catecholamines. They could be either sporadic or inherited. Either isolated or integrated in genetic syndromes such as Von Hippel Lindau (VHL) (OMIM193300) which is an autosomal dominant disorder resulting from germline mutations in the VHL gene.Observation: We report a 42-year-old man operated at 8 years old for bilateral pheochromocytoma revealed by adrenergic symptoms ...

Introduction: Cortisol has numerous actions on glucose metabolism and insulin action which explain the frequency of glucose abnormalities in Cushing’s syndrome (CS). The aim of our work was to assess the prevalence and characteristics of diabetes in CS.Material and methods: This is a retrospective study concerning 51 CS (44F/7M) in whom we looked for the presence of diabetes either by fasting glycaemia or 75 g oral glucose tolerance test. Thereafter...

Introduction: Cortisol activates lipolysis in adipose tissue resulting in the release of free fatty acids into the circulation, it also activates cholesterol and triglycerides synthesis. The consequence is an increase in total circulating cholesterol and triglycerides with their inherent risks on the cardiovascular system. The aim of our work was to assess the prevalence and characteristics of dyslipidaemia in Cushing’s syndrome (CS).Material and me...

Introduction: Patients with Cushing’s syndrome (CS) are prone to hypertension as cortisol stimulates renal reabsorption of sodium and enhances vascular sensitivity to catecholamine and angiotensin II. This explains the frequency of hypertension in patients with CS. The aim of our work was to assess the prevalence and characteristics of hypertension in CS.Material and methods: This is a retrospective study concerning 51 CS (44F/7M) in whom we looked ...

Introduction: Pituitary apoplexy is a rare endocrine emergency characterized by the sudden onset of severe headaches, vomiting, visual abnormalities and pituitary dysfunction secondary to an acute hemorrhage or infarction within a pituitary adenoma.Subjects and methods: We report a retrospective study from 2000 to 2014 of 23 cases with pituitary apoplexy. Their mean age was 38.7±14.8 years, with a male to female ratio of 2:1.R...