Endocrine Abstracts

The diagnosis of Cushing’s syndrome (CS) is based primarily on diagnostic tests evaluating the cortisol response to dexamethasone suppression. Tests based on oral administration of dexamethasone may be compromised by poor compliance. We evaluated the diagnostic accuracy of a novel intravenous dexamethasone suppression test (IDST). The test is performed by intravenous (iv) bolus injection of 8 mg dexamethasone, with blood cortisol determinations made before injection, then...

Aim: Loss of protective sensation (LOPS) commonly precede Diabetic foot ulcer (DFU) which is one of the most fearsome/serious diabetic complications and the leading cause of foot amputation in T2D patients. However, the prevalence of this high risk state is unknown.Methods: To estimate the presence of LOPS among hospitalized diabetes patients in internal wards, vibration perception and 10-g monofilament tests were done. Patients with foot ulcer or status...

The competence of endocrine nurse in the treatment of adrenal insufficiency (AI) is defined by the competence framework. Here is distinguished into Competent, proficient and expert. In these points, the nurse’s knowledge is presented and gives a good overview of already acquired knowledge and things to be learned. With the acquired knowledge the endocrine nurse is intended to treat, train and support patients with AI as far as possible. Due to differences in the health sy...

Breakpoint cluster region abelson fusion oncoprotein (BCR-ABL) targeted tyrosine kinase inhibitors (TKIs) are widely used in long-term medications of hematological malignancies. Numerous clinical observations confirmed that these drugs significantly modify the physiology of bone tissue as a side effect. Currently, there are numerous contradictory results regarding the complex effects of TKIs on bone metabolism, as well as there is no clear evidence to explain them, either in t...

Carney complex (CNC) is an autosomal dominant multiple neoplasia syndrome featuring cardiac, endocrine, cutaneous and neural tumours, as well as a variety of pigmented lesions of the skin and mucosa. Pituitary GH-secreting tumours are found in approximately 10% of patients with CNC. One of the genes responsible for CNC, the PRKAR1A gene, located on human chromosome 17q22-24, has recently been cloned. This represents a putative tumour suppressor gene, coding for the type 1alpha...

Introduction: High androgen levels and infertility in reproductive women, beyond the most common cause of polycystic ovary syndrome (PCOS), is often a challenge diagnosis. Ovarian steroid cell tumor is considered a rare subtype of hormone-secreting ovarian tumor, accounting for about 0.1% of all ovarian tumors.Aim: To report a case of extremely high testosterone levels in a woman with secondary amenorrhea but without signs of virilization, and describe d...

Introduction: Current treatment guidelines for patients with insufficiency of the hypothalamic pituitary adrenal (HPA) axis recommend weight adjusted glucocorticoid supplementation doses to minimize risk of negative side effects (e.g. osteoporosis etc).However, little is known on a potential dose-dependent effect of glucocorticoid supplementation on overall mortality in patients with pituitary disease. Non-functioning pituitary adenoma (NFPA) is one of t...

Background and Aim: Thyroid hormone beta receptor (TRβ) agonists have shown promising results to improve non-alcoholic steatohepatitis in preclinical studies and clinical trials. However, a recent cross-sectional study on human liver biopsies found that TRβ expression decreases during non-alcoholic steatohepatitis (NASH), which may indicate developing thyroid hormone resistance and pose a challenge for TRβ agonists. We aim to study how the changes in TRβ ex...

Introduction: Mutations activating USP8 have been detected in a high proportion of pituitary adenomas causing Cushing’s disease and have been linked to an increase of ACTH production in corticotroph cells. Whether USP8 mutations are involved in the tumorigenesis of the ectopic Cushing’s syndrome (ECS) caused by neuroendocrine tumors has not been studied.Patients and methods: In this work we evaluate the role of USP8 in a series of 17 t...

Objectives: Thyroid hormones (TH) affect cardiovascular functions via direct actions on the heart and via indirect actions on central nervous system. Mutations in TH receptor α1 (TRα1) cause Resistance to Thyroid Hormone α (RTHα), a disorder characterized by hypothyroidism in TRα1-expressing tissues including the heart.Methods: The current experiments aimed at investigating the role of peripheral and central TR&...