Endocrine Abstracts

Purpose: The liver is known to be protected from steatosis under the influence of high GH/IGF-1. Cytokeratin 18 (CK18) and insulin-like growth factor binding protein 7 (IGFBP7) increase in liver steatosis and fibrosis. Whether decreasing lipid content completely protects the liver from metabolic alterations and the response of CK18 and IGFBP7 to liver changes in acromegaly is unknown.Methods: This single-center, multidisciplinary, cross-sectional study i...

Aneurysmal subarachnoid hemorrhage has been reported to be associated with hypopituitarism. Also, internal carotid artery coil embolisation for aneurysmal hemorrhage is a rare cause of hypopituitarism. 58-year-old female patient who admitted to Emergency Department of Gazi University Medical Faculty due to visual loss and severe headache that did not respond to analgesics accompanied by nausea-vomiting starting 4–5 days ago. Sixth cranial nerve paralysis and bilateral tem...

Introduction: Glycogen storage disease type 1a (GSD1a) is an inborn error of metabolism with several metabolic decompensations including anaerobic glycolysis and lactic acidosis but few known about GSD1a-related hypercalcemia. Here we aimed to present a putative relationship between serum Ca and the affected metabolic parameters during metabolic decompensation of GSD1a.Case report: Two patients with GSD1a and hypercalcemia were retrospectively analyzed. ...

Introduction: Leptin is a 16-kDa peptide hormone secreted by adipose tissue and acts as a sensor for energy stores. It feedsback at the hypothalamic arcuate nucleus to suppress appetite. Leptin treatment has been highly effective in suppressing appetite in the rare cases of leptin-deficient obesity and improving the metabolic profile in congenital generalised lipodystrophy. These patients require 2.5–10 mg once daily recombinant leptin treatment. We hypothesised that prol...

Background: Primary hyperparathyroidism (PHPT) is associated with various musculoskeletal complaints. It is difficult to evaluate muscle strength as it is hard to extract objective data due to lack of definite methods for measurement.Objective: To assess the differences between PHPT patients and healthy controls regarding maximum foot force and plantar pressure distribution by using platform pressure measuring system [Footscan (RSscan)].<p class="abs...

Nivolumab is the first programmed death 1 (PD-1) immune checkpoint inhibitor. It is approved for use in advanced melanoma and squamous non small cell lung cancer (NSCLC). PD-1 immune checkpoint inhibitors can cause autoimmune disease of endocrine glands, including the thyroid. Here, we present a case of thyroiditis after nivolumab therapy.A 61 year-old female patient with NSCLC was consulted to endocrinology department for abnormal thyroid function test ...

Objective: Different methods are used to identify individuals with insulin resistance. The gold standard is the euglycemic-hyperinsulinemic clamp. However, in clinical practice, clamp is not preferred because it is cumbersome, the HOMA-IR index is used more often. The Trigliserid-glucose (TyG) index is a new and practical way to identify individuals with insulin resistance (IR). When compared to HOMA-IR, this index has been shown to be more reliable in determining insulin resi...

Aim: The primary objective of this study was to evaluate the structural and functional cardiac parameters with MRI in patients with primary hyperparathyroidism (pHPT) before and after successful surgery.Method: In this prospective study 16 patients with pHPT were included. Detailed cardiac magnetic resonance imaging (MRI) examinations were performed preoperatively and at six months post-surgery. Following parameters were measured: Left ventricle ejection...

Objective: Thyroid cancer (TC) screening in acromegaly is a controversial topic. The Endocrine Society opposes routine TC screening in acromegaly patients without a palpable nodule, and the American Thyroid Association does not consider acromegaly to be a high-risk condition for developing TC. However, acromegaly is associated with an increased risk of TC, and some centers opt for thyroid ultrasound screening even in the absence of palpable thyroid nodules. Being one of the su...

Purpose: Acromegalic patients carry a high burden of cardiovascular, metabolic, and neoplastic diseases, but there are limited studies focusing on morphological and functional changes in the kidneys.Methods: The data of acromegalic patients followed over a 43-year period at our center were examined for the development of chronic kidney disease (CKD), renal cysts, and urological cancers.Results: A total of 394 patients (202M/192F, m...