Endocrine Abstracts

Background: Children and young people (CYPwD) with a persistent high HbA1c are at greater risk of developmental and long-term complications. Diabetes services across the England & Wales are mandated to have a ‘high HbA1c’ policy by the Best Practice Tariff quality standards, to improve health outcomes. Aim: To evaluate the Birmingham Women’s and Children’s (BWC) Diabetes Team ‘High HbA1c Policy’ from 2016 – 2019.</p...

Background: Paget’s disease may affect as many as 3% of adults older than 40 years of age; it is often asymptomatic and usually progresses slowly. Paget’s disease affects men and women almost equally, but men tend to be more symptomatic. The disease is usually not clinically apparent until age 50–60 years. It usually progresses slowly and does not develop in new sites. Many different bones can be affected, and the lesions can vary from single, monostotic lesions...

Introduction: Isolated bone metastasis of endometrium carcinoma is rare; but if it occurs, pelvis and vertebrae are involved mostly. Co-existence of undiagnosed Paget’s disease in a patient with malignancy causes major problems in differential diagnosis.Case: A 77 year-old woman was admitted to our hospital with severe pelvic pain. She had been diagnosed with inoperable endometrium adenocarcinoma for over a year. Metastatic bone disease was suspecte...

Hypertrophic osteoarthropathy (HOA) is a syndrome characterized with proliferation of bones at the distal parts of extremities. Clubbing, periostitis of tubular bones and non-inflammatory arthritis of lower extremities are commonly seen as a part of this syndrome.66 years old male patient was admitted to our hospital with painful swelling of his left lower extremity for 2 months. He denies any other systemic symptoms such as fever and weight loss. He had...

Purpose: Paget disease is a disease of bone of unknown etiology with increased bone turnover that results in defective bone microarchitecture and bone deformity. Bisphosphonates are used in symptomatic Paget disease of bone. Clinical trials have shown that zoledronic acid was more effective than other bisphosphonates in treatment of Paget disease.Methods: In this study, we retrospectively reviewed the remission and relapse statuses of 12 patients with Pa...

Paget’s disease of bone (PDB) is the second commonest bone disease. The original disease description in 1876 by Sir James Paget remains an incisive, accurate report of the pathophysiology of PDB, which is characterised by focal regions of increased bone remodelling with initial excessive bone resorption and osteolytic lesions followed by long term increased bone formation and sclerosis. The majority of patients are elderly, many are asymptomatic. Those that are referred t...

Paget’s disease of bone is the second most common metabolic bone disease after osteoporosis. It is a condition characterised by abnormal bone cellular activity resulting in the formation of disorganised (and weaker) bone. Paget’s disease can affect single or multiple bones. In many cases it may be asymptomatic, however it can often be associated with pain affecting the pagetic bone or there may be ‘peri-pagetic’ pain related to altered biomechanics due to c...

Bone turnover markers (BTMs) may have a role in assessing bone turnover and response to intervention in Paget’s disease. We examined the clinical utility of bone turnover markers at diagnosis through analysis of our database of patients with radiographically confirmed Paget’s disease.We identified 36 patients (20 men); mean age at diagnosis was 71.6 years (range 54–84). Radionuclide imaging identified that 64% had polyostotic disease, with...

Case: A 77-year-old man was admitted with a pathological fracture of the right femur, which required intramedullary nailing. He had previously been diagnosed with Paget’s disease affecting the right femur and also hyperparathyroidism with a large parathyroid adenoma on Sestamibi scan which had been managed at another hospital. On this admission, his corrected calcium was 2.79 (2.15–2.55) mmol/l, PTH 643 (15–65) pg/ml and alkaline phosphatase 258 (30–130) U/...

Prevalence of Paget’s disease (PD) of bone as well as clinical and demographical presentation may differ between the populations.Aim: In this study we evaluate clinical and demographical parameters of Paget’s disease patients followed from endocrinology clinics in Turkey.Method: An invitation was sent to all tertiary endocrinology clinics to complete a survey on demographic clinical, laboratory parameters, treatment modal...