Endocrine Abstracts

Introduction: Cushing’s syndrome is rare disease with annual incidence 2/ million. It carries a high mortality rate if untreated. ACTH independent Cushing’s with Adrenal adenoma is responsible for 10% of cases. This is a case of a young gentleman with back pain, vertebral fracture, in presence of left adrenal incidentaloma, normal MRI pituitary, and hormonal profile indicative of possible non-detectable central pituitary lesion, diagnosis of likely adrenal Cushing&#1...

Background: University Hospitals Birmingham NHS Foundation Trust offers a comprehensive bone health assessment, through the Fracture Liaison Service (FLS), to individuals who sustain fragility fracture/s. Patients requiring assessment are identified daily through admissions from Accident and Emergency and Trauma and Orthopaedics. A bone density scan is requested for further investigations according to the FRAX tool to identify more accurately their fracture risk and to help de...

Patients with adrenal insufficiency (AI) should be informed about ‘sick day rules’ and risk of a life-threatening adrenal crisis if corticosteroids are abruptly stopped or if the steroid dose is inadequate.Aims and Methods: To assess current practice with regard to steroid advice given across medical specialties at Oxford University Hospital Trust. To assess patient knowledge both in a specialist Endocrine department and in a medical specialty ...

Methodology: Between Jan’20 to Jan’21, 364 patients on thyroid replacement therapy were included in the study and analysed retrospectively. They were divided in 2 groups. T4 group (189 on levothyroxine therapy {T4} therapy) & T3 group (175 on levothyroxine/liothyronine combination therapy {T3/T4}. Hypothyroidism was defined as TSH >4.2 mIU/ml on > 2 occasions > 2 weeks apart irrespective of their thyroid antibody (anti-TPO Ab) status or TSH > 4.2 ...

Background: The move from paediatric to adult services comes at a time in a young person’s life when they face multiple life challenges alongside managing their diabetes. Despite our NHS trust having a planned and integrated diabetes transition service, as per NICE (2016) and NHS England (2016) recommendations, we noticed a rise in patient’s not attending clinic and suboptimal glycaemic control.Aim: To review the data on clinic appointments att...

Aim: To asses the role of Liothyronine (T3)+Levothyroxine combination (T4) therapy in 70 overweight/obese patients with Thyrotropin Stimulating Hormone (TSH mIU/ml) between 2.5-5 who were unable to lose weight. Methods: Between Jan’ 20 - Jan’ 21, 70 overweight/obese patients with TSH 2.5 -5 performed on ± 2 occasions ± 4 weeks apart were retrospectively analyzed. 24% {17/70} had TSH 2.5-2.99, 37% {26/70} had TSH 3-3.99 & 39% {27/70} h...

We describe four female patients with T2DM, presenting with nocturnal dizziness (ND), low capillary blood glucose & low BP, that was partially relieved with oral glucose & salt water. C1: MB 66 years, on background of hypertension (HT, valsartan + hydrochlorthiazide (HCT) + amlodipine (AM) ), hypothyroidism (T4D) (levothyroxine 700 mg/week) & IHD (pEF) presented, 3 years into her diagnosis, A1c 52 mmol/mol, with unsteady gait, frequent falls (normal-neurolo...

Introduction: There is a known association between delayed puberty in autoimmune Addison’s disease in presence of polyglandular involvement, but constitutional delay still needs to be considered in these cases.Case: We report a 14-year-old boy who presented with a 4 month history of dizziness, fainting episodes and weight loss at the age of 12 years. He was stabilised on a reasonable dose of hydrocortisone and fludrocortisone after a diagnosis of Ad...

Aim: To asses the role of oral semaglutide (Sm) on weight & cardiac biomarkers (CB) in 69 patients with hypothyroidism optimally controlled using Liothyronine (T3)+Levothyroxine combination (T4) therapy (T3/T4).Methods: Between January 2022 and March 2022, 69 hypothyroid patients, who were treated using T3/T4 while on regular follow up, initiated Sm with the intention of weight loss and were retrospectively analysed....

Aims: To evaluate the effect of Liraglutide on clinical parameters in obese Type 2 diabetic patients with inadequate glycemic control despite treatment with oral hypoglycaemic agents (OHAs) and insulin.Methods: Three hundred and fifty three (M:232, F:121) obese (according to Asian-Indian criteria) type 2 diabetic patients with inadequate glycemic control (HbA1c>7% & <10%) attending outpatients clinic on insulin and OHAs were initiated on lira...