Endocrine Abstracts

Background: Through this study, we hoped to better understand the factors affecting recurrence-free survival in patients who have undergone curative intent resection for small bowel neuroendocrine tumors (SB-NETs). Extensive literature exists on recurrence predictors for pancreatic NETs but not for those of the small bowel. We hope to bridge this gap.Methods: We retrospectively evaluated patients who had received their index curative-intent operation for...

IntroductionLeukocyte recruitment is a key feature in (I/R)-induced tissue injury. We have developed and validated a novel method to study molecular mechanisms of leukocyte-endothelium interactions in the colonic microcirculation in vivo by use of inverted intravital fluorescence microscopy.Methods & ResultsIn male C57/BL6 mice the superior mesenteric artery was occluded 30 min and leukocyte rolling and ...

Intrauterine growth restriction (IUGR) is associated with postnatal metabolic complications, which include glucose intolerance in adulthood. However, information is limited on the progression of insulin secretion and its action in young IUGR infants. The objective of this study was to determine glucose stimulated insulin secretion and insulin action in young lambs with placenta insufficiency-induced IUGR.Placental insufficiency-induced IUGR was created b...

The TSH B/I ratio is normally reduced overnight and is substantially reduced in patients with overt central hypothyroidism due to h-p axis tumours before and after treatment. It is unknown if similar changes in the TSH B/I ratio in the absence of overt central hypothyroidism contribute to the increased TSH levels seen in cancer survivors who undergo h-p axis irradiation. Thus, we selected 9 patients with the highest TSH levels out of a previously reported cohort of 37 euthyroi...

Introduction: The clinical implications of QTc and P wave dispersion in patients with Cushing’s syndrome have not been studied previously. In this study, we aimed to compare QTc dispersion and P wave dispersion in patients with Cushing’s syndrome and healthy subjects.Material and method: Sixteen patients with Cushing’s syndrome diagnosed on clinical, laboratory and imaging findings and 16 age and sex matched control subjects were included....

Background: Hip fractures are associated with high morbidity and mortality rates amongst older adults. The Irish Hip Fracture Database Standard 5 requires that all patients with a hip fracture have a bone health assessment completed. The majority are prescribed bone protection therapy to reduce further fractures. We sought to analyse the compliance and receipt of bone protection in patients presenting for DXA scan post hip fracture.Methods: We retrospect...

Selenium (Se) is an essential trace element and is important for maintaining health and preventing disease. Se exhibits its biological function as the 21st proteinogenic amino acid selenocysteine (Sec). Different cis and trans acting factors are necessary for incorporation of Sec into proteins. Se can be transported and stored as Sec in selenoprotein P (SePP), a liver-derived protein which contains up to 10 Sec residues per protein in humans. Thus, SePP functions...

Introduction: The serum calcium/phosphorus (Ca/P) ratio has been proposed to identify patients with primary hyperparathyroidism and chronic hypoparathyroidism (HPT) from healthy subjects. However, other disorders of the Ca-P metabolism might present similar biochemical profile of HPT, such as pseudohypoparathyroidism (PHP), for which the use of Ca/P can be useful. Aim: To test the performance of Ca/P ratio in the diagnosis of PHP in comparison to healthy...

Background: Small bowel neuroendocrine tumors (sbNETs) incidence is on the rise. Given that sbNETS are often multifocal with high risk of regional nodal metastasis, open resection with lymphadenectomy is the gold standard approach as it offers manual palpation of the entire small bowel. We evaluated the accuracy of preoperative DOTATATE PET/CT in estimating the number of lesions and the presence of nodal disease compared to postoperative pathology findings. We hypothesize that...

Introduction: Primary hyperparathyroidism (PHPT) is a common endocrine disorder that is characterized by hypercalcemia and elevated or normal levels of parathyroid hormone (PTH). Most PHPT cases are incidentally discovered when routine laboratory analysis reveals hypercalcemia. PHPT should be considered in any person with elevated serum calcium (Ca) levels and no clear evidence of malignancy. Serum phosphorus (P) is low due to the phosphaturic effects of PTH and mostly in the ...