Endocrine Abstracts

Background: Acromegaly is a rare endocrine disorder due to growth hormone excess attributed to a pituitary tumor, in most cases. Epidemiological data of acromegaly are derived from national tumor registries or population studies while there are no published data in the Greek population except for a few small studies regarding treatment outcome.Methods: We carried out a retrospective ongoing observational study to determine the epidemiology, presentation ...

Acromegaly is a rare and insidious endocrine disease, with increased morbidity and mortality mainly due to delayed diagnosis and inadequate control. There are many population studies assessing the epidemiology of acromegaly in Europe while in Greece, there are no published data except for a few small studies regarding treatment outcome.Aim: To determine the epidemiology, presentation and outcome in patients with acromegaly in Crete, Greece.<p class="...

Erectile dysfunction is a common complaint of men with hypogonadism. We present the case-history of a 42-year-old man who complained of erectile dysfunction for four years. Previous paternity was mentioned in his past medical history. On clinical examination his appearance was eunuchoid with frontal balding, reduced chest hair and lipomastia. Bilateral ptosis was also noticed and after being questioned the patient admitted that he had surgically repaired eyelid ptosis one year...

Introduction: In a US study of general practitioners, 50%-60% of their working time was found to be dedicated to paperwork and electronic medical record-keeping (including electronic prescription – EPC writing)1.Aim: Given the mandatory use of EPC in Greece, we wanted to assess the time required for this in the daily practice of our outpatient endocrinology clinic.Method: In one of the outpatient (OUP) clinics of t...

Objectives: GH in addition to promote linear growth during childhood influences several key metabolic processes as well. In the transition period, from late adolescence to early adulthood, GH plays an important role in skeletal mineralization and muscle mass maturation as well as in developing a favorable cardiometabolic profile. Therefore, several lines of evidence propose GH replacement to be continued if GH evaluation at the transition age fulfills established criteria. The...

Background: Budd-Chiari syndrome, characterized by abdominal pain, ascites and hepatomegaly, is a rare condition, caused by thrombotic hepatic venous outflow obstruction. Diabetes mellitus is associated with impairment of the coagulation and fibrinolysis pathway, suggesting its involvement in the pathogenesis of venous thromboembolism. There are few cases of patients with Budd-Chiari syndrome and Diabetes Mellitus, reported in the literature.Case present...

Introduction: The role of thyroid hormones is important in testicular development and function (involvement in Sertoli cell proliferation and functional maturation control and postnatally in Leydig cell differentiation and steroidogenesis). Additionally, thyroid hormone receptors are found in testicular cells throughout development and in adulthood. Our aim was to study thyroid hormone effects on testicular function.Materials and methods: We retrospectiv...

Introduction: Exposure to air pollution and in particular to nitrogen dioxide (NO2) or particulate pollutants less than 2.5 µm (PM2.5) or 10 µm (PM10) in diameter has been linked to thyroid (dys)function in pregnant women. The environmental degradation that has occurred in recent years in the region of Athens led us to a local study of air pollution against thyroid function in pregnant women in Athens. We hypothesized that there may be a dose-effect relati...

Objective: Statins are the mainstay of treatment for patients with familial hypercholesterolaemia (FH). The purpose of this study was to systematically investigate and meta–analyze the best available evidence from randomized–controlled trials (RCTs) regarding the efficacy and safety of statins in children and adolescents with FH.Methods: A comprehensive search was conducted in PubMed, Scopus and Cochrane, up to July 10, 2019. Data were expres...

Background: QT interval reflects cardiac ventricular repolarization and, if prolonged, increases the risk of malignant arrhythmias such as torsade de pointes. QT interval duration is similar in boys and girls during childhood but shortens in males after puberty. In fact, reference limits for QTc in adults reflect this difference, i.e. lower than 460 ms in women and lower than 440 ms in men. Experimental studies suggest that testosterone is the major contributor to shortening o...