Endocrine Abstracts

Background: Non-classic adrenal hyperplasia (NCAH), comparatively a rare disease, is characterised by mild to moderate hyperandrogenemia, hirsutism, oligomenorrhea, insulin resistance which incidentally are the hallmarks of polycystic ovary syndrome (PCOS)- a common disorder among reproductive aged women. The data on 17-hydroxyprogesterone (17-OHP)serum levels in NCAH has been reported globally but there is limited data available regarding the normal range among healthy Indian...

Anabolic steroids enhance performance in atheletes, but can lead to life threatening consequences. We report a 33-year-old male amateur body-builder using anabolic steroids, presenting with acute inferolateral myocardial infraction and marked hyperlipidaemia. He had no known cardiovascular risk factors. Despite rapid thrombolysis, peak creatinine kinase was 3,348 iu/l, signifying significant myocardial damage and a markedly raised total cholesterol of 10.6 mmol/l, with a low H...

Carcinoid tumours are the most common neuroendocrine tumors with an estimated incidence of 7-13/ million population. The clinical symptoms of carcinoid tumours usually relate to presence of the carcinoid syndrome, local symptoms or metastases. Most are asymptomatic with only 10% manifesting the 'carcinoid syndrome'. We report an 86 year-old lady referred for evaluation of multiple subcutaneous, nodules around her neck and upper back, with a suspicion of underlying lymphoprolif...

Anabolic steroids enhance performance in atheletes, but can lead to life threatening consequences. We report a 33-year-old male amateur body-builder using anabolic steroids, presenting with acute inferolateral myocardial infraction and marked hyperlipidaemia. He had no known cardiovascular risk factors. Despite rapid thrombolysis, peak creatinine kinase was 3,348 iu/l, signifying significant myocardial damage and a markedly raised total cholesterol of 10.6 mmol/l, with a low H...

Background: Cushing’s syndrome (10-15/million people diagnosed/year) is quite rare with Cushing’s disease accounting for >70% of cases in adults. Spinal epidural lipomatosis (SEl) secondary to endogenous Cushing’s syndrome is even more rare condition (8 reported cases so far) of which 3 cases are secondary to Cushing’s disease. Here, we highlight a case of ACTH-dependent Cushing disease with resultant spinal epidural lipomatosis (SEl) that was treated w...

Experimental results have shown that the presence of endocrine disrupting chemicals (EDCs) such as the diphenyl compound DDT and its analogue DDE, allosterically cause the release of the stably bound dihydrotestosterone (DHT) from the steroid binding site of the Androgen Receptor (AR) ligand binding domain. It was hypothesized that EDCs mediate this effect via binding to the Binding Function 3 (BF3) surface binding site. Mutations of three BF 3 amino acids (F673K, F673W, G724R...

The prevalence of diabetes is increasing worldwide. According to the recent World Health Organization (WHO) estimates, more than 180 million people worldwide have diabetes. This number is likely to be more than the double by 2030. It is estimated that the developing countries will bear the brunt of diabetes epidemics in the 21st century. It is well known now that increased rates of other chronic diseases, such as hypertension, obesity, cardiovascular diseases are highly associ...

Case History: A 16 yr old patient presented to us concerned about her short statue. Her father and mother were at the 9th centile and her sister was at the 25th centile in adult life. She was otherwise well having gone through a normal puberty in her early teens and was currently on the oral contraceptive pill having regular periods. On examination she did display some features of Turner’s syndrome; short stature, short neck and cubitus valgus deformity. Cytogenetic analy...

We report the case of a 41-year-old woman who was under investigation for deranged liver function tests following an insurance medical when she also serendipitously was found to have hypercalcaemia - 2.70 millimols per litre (Reference range 2.45-2.65 millimols per litre). She was completely asymptomatic and on no medication. She had an elevated Parathyroid hormone level of 11.6 picomols per litre (Reference range 0.9-8.0 picomols per litre), consistent with primary hyperparat...

Introduction: Prevalence of prolactinoma is approximately 10/100,000 (men) and 30/100,000 (women) and dopamine agonists remain pharmacological treatment of choice. Cabergoline, an effective dopamine agonist, is preferred due to better tolerability withhigher efficacy in lowering prolactin and reducing tumour size in comparison with bromocriptine. Digital vasospasm, known adverse effect of Bromocriptineis mediated by activation of α1 adrenergic receptors. ...