Endocrine Abstracts

Background: Malnutrition and weight loss are well-recognized complications of Crohn disease (CD), however nutritional routine assessment is not commonly performed, resulting in under-detection and under-treatment of both malnutrition and nutrient deficiencies. In fact, a number of nutrition screening tools are available including the Nutritional Risk Index (NRI).Aim: The aim of this study was to investigate the prevalence and the associated factors of ma...

Background: Colorectal cancer is the world’s third most common cancer. The prognosis is mainly determined by the stage of the tumor, but several other factors related to the patient, such as co-morbidities, may also have an impact on the disease course. The aim of our study was to assess the prognostic value of diabetes and obesity in colorectal cancer.Methods: We conducted a retrospective study including patients diagnosed with primary colon or rec...

Introduction: Antithyroid drugs (ATD) are usually the first-line treatment for Graves’ disease (GD). It represents an effective treatment with good compliance. This therapeutic modality can be the cause of adverse effects including hematological, cutaneous and hepatic complications. The aim of our study is to evaluate the efficacy of ATD as well as its tolerance in patients with GD.Methods: It is a retrospective study that included 76 patients, with...

Context: Reoperative surgery is the most efficient treatment of cervical persistent thyroid carcinoma. The extent of the surgery should be guided by the preoperative imaging findings, the primary surgery and the patient’s prognosis. However, there is no consensus concerning the optimal surgical strategy.Objective: Primary objective was to evaluate morbidity of a reoperative surgery. Secondary objectives were to evaluate performances of preoperative ...

Introduction: 21-hydroxylase deficiency represents 95% of congenital adrenal hyperplasia. The non-classical form manifests in women mainly by hirsutism, menstrual disorders, or infertility. We present three patients’ cases.Observations: Patient N.C., 17 years old, who presented with hirsutism beginning at the age of 8 years and progressively worsening after puberty. The patient had her menarche at the age of 9 years, with short and irregular menses....

Introduction: Patients with type 2 diabetes mellitus are considered at least at high cardio-vascular risk. Cardiovascular risk factors must be regularly screened. Hyperhomocysteinemia is considered as an independent risk factor for atherosclerotic disease and coronary disease in some studies. The aim of our study was to confirm the association between hyperhomocysteinemia and atherosclerotic disease in patients with type 2 diabetes.Methods: We performed ...

Introduction: Uncontrolled hyperglycemia in diabetes is a common cause of microvascular complications, including diabetic nephropathy (DN). Despite improvements in the management of type 2 diabetes (T2DM), diabetic nephropathy is still associated with high morbidity and mortality. The objective of our study is to evaluate the predictive factors of DN in adults with T2DM in order to prevent its development.Patients and Methods: A retrospective study, incl...

Introduction: Werner syndrome is a rare genetic disease affecting the WRN gene, of autosomal recessive inheritance.Case-presentation: We report the case of a 34-year-old patient who presented with erectile dysfunction and asthenia. His brother underwent surgery for meningioma. He was also diagnosed with hypogonadism, suffered from bilateral cataract and diabetes, and died following acute Leukemia at the age of 35 years. Our patient is from a second-degre...

Introduction: Professional athletes commonly use anabolic-androgenic steroids (AAS) to enhance performance. AAS include testosterone and its numerous synthetic analogs. AAS have numerous adverse effects among which central nervous system effects that include psychosis, delirium, mania and depression. Trenbolone is an AAS medication which is used in veterinary medicine for cattle muscle growth. What makes Trenbolone interesting is that it’s also capable of inducing Selecti...

Introduction: Cushing’s disease (CD), a hypercorticism caused by an ACTH-secreting pituitary adenoma, was associated with a 5-year survival of only 50%. Although advances in management have significantly reduced mortality, the results of transsphenoidal surgery, the gold standard in the treatment of CD, vary from patient to patient.Objective: The aim of our study is to evaluate the results of transsphenoidal surgery in CD (evolution, complications) ...