Endocrine Abstracts

Background: Adrenal haemorrhage is a rare clinical presentation with an incidence of only 5 in 1,000,000 [1]. 10% of these are bilateral adrenal haemorrhages, which has very high mortality rate of 15 % [2]Case summary: 22 years old female had C-section for persistent to breech presentation at term. She has a history of preterm delivery due to chorioamnionitis during previous pregnancy. Patient had about 1.2L post-partum haemorrhage....

Background: The correlation linking Myasthenia Gravis (MG) and pituitary adenomas is exceedingly uncommon. Our thorough investigation of medical literature uncovered merely eight documented cases showcasing this association. Notably, five of these cases specifically involved adenomas that secreted prolactin¹. Two instances implicated a non-functional pituitary adenoma in this rare association². Solely one case was identified involving a growth hormone (GH)-secreting ...

Introduction: The coexistence of myasthenia gravis (MG) and autoimmune thyroid disease (AITD) is well recognised, with 5-10% of MG patients also having an AITD1-2. Among AITD, hyperthyroidism association with MG is the most common3. Conversely, MG has a relatively low incidence of around 0.2% in individuals with hyperthyroidism2, 4. This implies a potential immunological cross-reactivity between the neuromuscular junction and thyroid components...

A gentleman in his 70s with a background of atrial fibrillation, hypertension, and mesothelioma undergoing immunotherapy via Nivolumab and Ipilimumab, presented with general unwellness, fevers, confusion, and headaches. He had no prior endocrine history but was found to have significantly deranged thyroid function tests. He was treated for thyrotoxicosis and an impending thyroid storm with carbimazole. He remained treatment resistant for several days, with continuous delirium,...

Introduction: Primary hyperparathyroidism (PHPT) is the most common cause of hypercalcemia, often caused by a single adenoma (85%) or four-gland hyperplasia (15%). Brown tumors are rare erosive bony lesions caused by localised rapid osteoclastic turnover resulting from hyperparathyroidism.Case presentation: A 28-year-old lady presented to the Emergency Department with a 3-day history of fever, dry cough and generalized body aches. She reported sudden ons...

Introduction: Cinacalcet acts at the calcium-sensing receptors on parathyroid cells to increase the sensitivity to circulating calcium concentrations. Studies have shown that this treatment is an effective means of managing hypercalcaemia in primary hyperparathyroidism.Aims: The aim of this study was to determine the outcomes of patients who had received cinacalcet for at least 3 months for primary hyperparathyroidism.Methods: We i...

Introduction: Adrenal haemorrhage (AH) carries high mortality and morbidity. It can be unilateral or bilateral (BAH), trauma or non-trauma (NT) related. The predisposing factors include adrenal tumours, anticoagulation, thrombocytopenia, sepsis, thromboembolic disease, pregnancy, liver transplant and vaccine-induced-immune-thrombocytopenia-and-thrombosis. BAH can result in an adrenal crisis in up to 15%. BAH is usually associated with conditions contributing to adrenal vein sp...

Background: Management of large indeterminate adrenal masses detected during pregnancy is challenging due to the risk of malignancy and the obstetric risks of surgical intervention. The spectrum of endocrine-related complications of Covid-19 is expanding. We present a case that highlights the challenging management of a large adrenal mass during pregnancy and draws attention to a rare complication of Covid-19.Case description: 26 yr-old lady presented wi...

Background: Medullary thyroid carcinoma is a rare type of thyroid cancer that is either sporadic or familial. It occasionally occurs alongside parathyroid hyperplasia and pheochromocytoma as part of MEN2A. Our aim was to study the presence and patterns of above mentioned characteristics of medullary thyroid carcinoma in our population.Methodology: This is a retrospective study conducted in a tertiary care hospital of Pakistan in which data of medullary t...

Post-prandial hypoglycaemia (PPH) can be associated with debilitating symptoms. Causes include altered physiology post-bariatric and upper gastrointestinal (GI) surgery and rarely noninsulinoma pancreatogenous hypoglycemia syndrome and insulin antibodies. We present a case of 49y female with no prior GI surgery presenting with debilitating hypoglycaemia with blood glucose falling to 2.8 mmol/l responding to glucose. Freestyle Libre monitoring confirmed hypoglycaemia 2-3 h post...