Searchable abstracts of presentations at key conferences in endocrinology

ea0094p176 | Adrenal and Cardiovascular | SFEBES2023

Current perceptions and practices by general practitioners (GPs) in the management of resistant hypertension

Wong Wai Kit Clement , Rui Lee , Leong Kwong Fei Eugene , Lee James , Pruar Troy , Parameswaran Rajeev

Introduction: About 12% of patients present to the GPs with hypertension or related symptoms. The current practice of managing resistant hypertension in primary care is inconsistent and general practitioners (GP’s) do not have a criteria for referral to tertiary care.Methods: Quantitative anonymized online survey of 26 questions on the current prescribing practices and thresholds for referral of resistant hypertensi...

ea0037ep596 | Obesity and cardiovascular endocrinology | ECE2015

Increased expression of ATP-binding cassette transporter A1 by cilostazol may be a possible mechanism for its protective effect against hepatic steatosis

Cha Bong-Soo , Park Tae Sun , Jeon Byung Hun , Lee Yong-Ho , Yun Mi Ra , Lee Byung Wan , Kang Eun Seok , Lee Hyun Chul

Objective: Cilostazol, a selective inhibitor of phosphodiesterase 3, which has been widely used in patients with atherosclerotic diseases, is known to have additional beneficial effects on dyslipidemia. ATP-binding cassette transporter A1 (ABCA1) plays a critical role in the regulation of intracellular cholesterol levels in hepatocytes. We aimed to investigate the effect of Cilostazol on hepatic steatosis and its underlying mechanism related to ABCA1.Met...

ea0035p189 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Serum cholesterol concentration and prevalence, awareness, treatment, and control of high LDL cholesterol in the Korea National Health and Nutrition Examination Surveys 2008–2010

Lee Yong-ho , Lee Byung-Wan , Kang Eun Seok , Lee Hyun Chul , Baik Sei Hyun , Kim Dong-Sun , Cha Bong Soo

Introduction: The mortality rate from cardiovascular disease (CVD) among young adults has declined less than that in the older population, raising concerns about the increasing prevalence of obesity-related conditions including hypercholesterolemia in the younger population. We investigated the age-standardized mean levels of serum cholesterols and the prevalence, awareness, treatment and control rates of hyper-LDL-cholesterolemia based on age.Methods: N...

ea0092ps3-27-01 | Thyroid Cancer clinical 3 | ETA2023

Clinicopathological features of intrathyroidal thymic carcinoma: A single center experiences

Joong Chung Ho , Seok Lee Jin , Sung Lee Jun , Jun Yun Hyeok , Chang Hojin , Mo Kim Seok , Chang Hang-Seok , Sang Lee Yong

Intrathyroidal thymic carcinoma (ITTC) is a rare thyroid malignancy. Its histology resembles that of squamous cell carcinoma (SCC) of the thyroid. However, ITTC shows a much more favorable prognosis than SCC. We analyzed the backgrounds and clinicopathological features of 10 patients who treated with ITTC in our medical center. Five patients was male, and another five was female. The average tumor size was 4mm, and it ranged from maximum 68mm to minimum 13mm. In pre-operative ...

ea0092ps3-29-09 | Treatment 2 | ETA2023

Effects of neoadjuvant chemoradiotherapy on unresectable anaplastic thyroid carcinoma

Seok Lee Jin , Sung Lee Jun , Jun Yun Hyeok , Chang Hojin , Joon Chung Ho , Mo Kim Seok , Sang Lee Yong , Chang Hang-Seok

Background: Anaplastic thyroid carcinoma (ATC) is associated with the highest mortality risk of any thyroid-arising tumor; however, there is currently no effective therapy for ATC, and multimodal therapy is associated with a relatively high mortality risk. Here, we investigated the effects of neoadjuvant chemoradiotherapy on patients with ATC treated with paclitaxel and intensity-modulated radiation therapy (IMRT).Methods: The medical records of 157 pati...

ea0099ep28 | Diabetes, Obesity, Metabolism and Nutrition | ECE2024

The relationship between continuous glucose monitoring metrics, circadian rhythms, and the presence of albuminuria in insulin-using patients with type 2 diabetes

Young Lee Da , Lee Jung-Been , Jung Inha , Young Park So , Hee Yu Ji , A Seo Ji , Lee Heon-Jeong , Hee Kim Nan

Background: We aimed to explore the relationship between continuous glucose monitoring (CGM)-derived indicators and the presence of albuminuria taking circadian features into consideration concurrently in Insulin-using patients with type 2 diabetes.Methods: We analyzed data from 129 insulin-treated type 2 diabetes patients in Korea University Ansan Hospital. Over 10 days, we collected time-series data using Dexcom G6, Fitbit, and food diaries, along with...

ea0077p8 | Adrenal and Cardiovascular | SFEBES2021

Comparative steroid profiling in large animals

Morgan Ruth , Denham Scott , Lee Patricia , Homer Natalie

Large animals are increasingly used a models for endocrine research. Unlike rodents they are cortisol-dominant and thus more similar to humans. In this study we use two novel analytical methods to compare the steroid profile of pigs, sheep and humans; 1. Simultaneous quantification of primary glucocorticoids, glucocorticoid precursors and mineralocorticoids in plasma (>20 steroids); 2.Quantification of glucocorticoids metabolites (>10 ...

ea0077p177 | Metabolism, Obesity and Diabetes | SFEBES2021

Obesity-induced upregulation of chemokine Ccl4 in mouse visceral adipose tissue: effects on β-cell function

Ashik Tanyel , Atanes Patricio , Lee Vivian , Persaud Shanta

Introduction: Adipose tissue-derived peptides, known as adipokines, act as key regulators of metabolic homeostasis, but little information is available on adipokine-mediated cross-talk with β-cells via islet GPCR interactions, nor whether this is altered in obesity. The expression profile of islet GPCR peptide ligand mRNAs in visceral adipose tissue from lean and diet-induced obese mice was therefore defined and the functional effects of Ccl4 on β-cells were characte...

ea0081p212 | Thyroid | ECE2022

Identifying the use of clinical and radiological parameters to assess moderate-severe Graves’ Orbitopathy − a multi-centre analysis of the characteristics of patients with Graves’ Orbitopathy

George Nicole , Lee Vickie , Feeney Claire , Bhatia Kunwar , Ali Amina

Background: Early diagnosis and surveillance of Graves’ Orbitopathy (GO) is essential to prevent severe, sight-threatening complications and long-term disability; therefore, it is highly desirable to identify risk factors and early predictors of severe disease. GO is clinically assessed using the Clinical Activity Score (CAS) and the EUGOGO Severity Scale (ESS), which are subjective, qualitative tests that are used to evaluate the activity and severity at the anterior orb...

ea0050oc2.2 | Clinical Highlights | SFEBES2017

Combined immunosuppression & radiotherapy in thyroid eye disease (CIRTED) trial: A multi-centre, double-masked, factorial randomised controlled trial

Taylor Peter , Rajendram Rathie , Uddin Jimmy , Lee Richard , Dayan Colin

On behalf of the Combined immunosuppression & radiotherapy in thyroid eye disease (CIRTED) InvestigatorsBackground: Thyroid eye disease is an inflammatory orbital condition which causes visual dysfunction and psychological morbidity. Current evidence is conflicting on the benefit of radiotherapy and antiproliferative immunosuppression in addition to systemic corticosteroid treatment. In particular, little is known about clinical outcomes mor...