Endocrine Abstracts

GH levels decline with age and weight gain and are enhanced in response to nutrient deprivation. Under these circumstances, GH levels are negatively correlated with IGF1 and insulin levels. Since IGF1 and insulin can directly inhibit GH synthesis and release from primary pituitary cells of different species, it is commonly accepted that changes in circulating IGF1 and insulin serve to directly regulate somatotrope function in response to metabolic extremes. However, teasing ap...

Context: Primary aldosteronism (PA) represents the most frequent cause of a curable secondary arterial hypertension. Conflicting data have been published regarding the effect of aldosterone excess on glucose and lipid metabolism.Objective: Our aim was to analyze insulin sensitivity and beta cell function in a cohort of PA patients. Prospective follow-up investigations were performed in a subgroup of patients before and after adrenalectomy to assess the m...

Introduction: An increased frequency of autoimmune diseases and an elevated incidence of autoantibodies have been observed in Turner syndrome (TS), but indirect immunofluorescence (IIF) has not been able to demonstrate autoantibodies against the adrenal cortex. We asked if the more sensitive radioimmunosorbant assay employing recombinant human 21-hydroxylase was able to identify autoantibodies against 21-hydroxylase, (21OH-Ab) in TS patients; 21-hydroxylase is the major adrena...

Objective: The risk of aortic dissection is 100-fold increased in Turner syndrome (TS). Increased blood pressure (BP) and heart rate is present as well as an increased risk of ischemic heart disease and diabetes. This study aimed to prospectively assess heart rate variability (HRV) in TS and its relation to aortic dimensions.Methods: Adults with TS (n=91, aged 37.4±10.4 years) recruited through the Danish National Society of Turner Syndrome...

GH is an important regulator of longitudinal growth in children and metabolism in adults. GH is used for treatment deficiency disorders in both children and adults. GH treatment is safe and well tolerated. However, its clinical use is limited to daily s.c. injections which poses a challenge for both the patients and the physicians and has prompted research into alternative approaches to GH treatment.NNC0195-0092 is a hGH derivative conjugated with an alb...

Gangliocytomas are uncommon neuronal tumors that can sometimes cause endocrine syndromes. A few such cases have been reported in association with Cushing’s disease. In most instances, the tumor contained CRH and was associated with pituitary corticotroph hyperplasia or adenoma (mixed lesion). Only one case of isolated gangliocytoma causing Cushing’s disease per se has been described.We report the case of a 62 year-old woman whose clinical pictu...

Introduction: Hyponatremia (serum sodium ≤135 mmol/l), the most common electrolyte disorder encountered, has been associated with increased mortality in patients with particularly cancer, heart failure, chronic kidney and liver disease. However, evidence of the clinical implications in broader populations is scarce, and uncertain due to confounding from preexisting disease. We aimed to examine the association between admission-hyponatremia and 30-day mortality in acute n...

The ERCUSYN (European Registry on Cushing’s syndrome (CS)) study is a project funded by the European Commission Public Health Program (PHP 800200), of which the ESE is one of the 41 Partners from 25 countries. The aims include obtaining prospective and follow-up data at EU level on epidemiology, mortality, outcome of therapies, co-morbidities, assessment of diagnostic and therapeutic strategies, quality of life evaluation using a disease-generated questionnaire (CushingQo...

Context and objective: GH and IGF1 both have neuroprotective and regenerative effects in experimental stroke. Our aim was to investigate whether the endogenous serum-IGF1 (s-IGF1) levels were correlated to recovery of functional independence in stroke patients.Subjects and methods: The analysis of s-IGF1 was performed in 400 patients of both sexes, aged 18–69 years old, and 40 controls previously included in the Sahlgrenska Academy Study on Ischemic...

Data on coexisting Graves’ disease (GD), systemic lupus erythematosus (SLE), and hypoparathyroidism (hypop) are limited. Scanty case reports have described hypoparathyr or hypothyroidism (late complication) following external irradiation to the neck. The thyroid and parathyroid glands may be sensitive to the immunologic or irradiation damage.A 34-year old AA woman presented with tetanic-like cramps, easy skin bruising, fatigue, weight gain, nocturia...