Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep1271 | Clinical Cases–Thyroid/Other | ECE2015

Late-diagnosed primary hyperparathyroidism resulting in loss of kidney and advanced osteoporosis

Jacewicz Malgorzata , Zielinska Anna , Poplawska-Kita Anna , Szelachowska Malgorzata , Gorska Maria

Introduction: The report describes the case of a late-diagnosed primary hyperparathyroidism in the patient, who developed catastrophic renal complications and such advanced osteoporosis, that hungry bone syndrome occurred after removal of parathyroid adenoma.Case report: A 63-year-old woman with long-lasting nephrolithiasis was admitted to the hospital due to high PTH discovered in a routine laboratory testing. She had undergone left-side nephrectomy 2 y...

ea0035oc1.4 | Thyroid clinical | ECE2014

Consequences of experimental hyperthyroidism on brain structure and function in humans

Dirk Anna-Luise , Goebel Anna , Heldmann Marcus , Iwen Alexander , Brabant Georg , Munte Thomas

Objective: Disturbed levels of thyroid hormones are associated with neuropsychiatric disorders, including memory impairments. Even short-term hyperthyroidism may affect properties of the human brain. To investigate the influence of thyroid hormones, we conducted functional neuroimaging. The aim of this study was to evaluate functional changes in working memory performance.Materials and Methods: Twenty healthy, male, right-handed subjects (age range 21&#1...

ea0035p133 | Calcium and Vitamin D metabolism | ECE2014

Interdisciplinary aspects of primary hyperparathyroidism: symptomatology in a series of 100 cases (single-centre experience)

Jodkowska Anna , Tupikowski Krzysztof , Szymczak Jadwiga , Bohdanowicz-Pawlak Anna , Bolanowski Marek , Bednarek-Tupikowska Grazyna

Introduction: Primary hyperparathyroidism (PHPT) is a common endocrine disorder. Beside renal and skeletal complications, it has a wide variety of nonspecific symptoms from other organs that may mimic other diseases and delay the diagnosis. Nowadays PHPT evolves to less-symptomatic.Aim: The aim is to revise symptomatology profile of PHPT in a single region of Poland; and to help early PHPT diagnosis – encouraging interdisciplinary contact between me...

ea0035p806 | Paediatric endocrinology | ECE2014

25-Hydroxyvitamin D concentrations before and in the 1st year of GH treatment in relation to height velocity, IGF-1 and bone age

Witkowska-Sedek Ewelina , Pyrzak Beata , Sagala Magdalena , Majcher Anna , Kucharska Anna

Introduction: The start of GH (rhGH) treatment in children with GH deficiency (GHD) causes a significant increase in bone turnover and increases height velocity. The increase in IGF1 concentrations during rhGH treatment is a marker of the efficiency of treatment. Bone age delay at baseline is related to GHD and is a good predictor of height velocity during treatment. A significant increase in bone turnover during rhGH treatment results in an increased demand for vitamin D. It ...

ea0035p862 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Assessment the relationship between TSH and selected anthropometric parameters: preliminary report

Koszowska Aneta , Nowak Justyna , Bronczyk-Puzon Anna , Jagielski Pawel , Dittfeld Anna , Kulik Karolina , Zubelewicz-Szkodzinska Barbara

Introduction: The majority of secreted hormones influence the whole body, its weigh and constitution as the results of ongoing metabolism. Scientific studies have reported the existence of relationship between the TSH and selected anthropometric parameters such as BMI or body weight.Aim: The aim of the study was to assess the relationship between the value of TSH and selected anthropometric parameters in the group of endocrine patients.<p class="abst...

ea0035p1123 | Thyroid Cancer | ECE2014

Sodium–iodide symporter and its microRNA-dependent deregulation in papillary thyroid carcinoma.

Kotlarek Marta , Gierlikowski Wojciech , Kubiak Anna , Maciag Monika , Jazdzewski Krystian , Wojcicka Anna

Objectives: The sodium/iodide symporter (NIS) is a glycoprotein with unique ability of transporting iodine into the thyroid follicle. Apart from the importance in thyroid hormone synthesis, this function of NIS allows the use of radioactive iodine to target residual and metastatic thyroid cancer after thyroidectomy. However, 20–30% of thyroid tumors exhibit lowered expression of NIS, resulting in decreased uptake of radioiodine and inefficient post-surgical therapy. Mecha...

ea0035p1128 | Thyroid Cancer | ECE2014

Next-generation sequencing reveals a novel thyroglobulin-embedded microRNA gene deregulated in papillary thyroid carcinoma

Kolanowska Monika , Wojcicka Anna , Kubiak Anna , Swierniak Michal , Maciag Monika , Wiechno Wieslaw , Jazdzewski Krystian

Introduction: Papillary Thyroid Carcinoma (PTC) exhibits activation of MAPK (Mitogen-activated protein kinases) pathway, leading to uncontrolled cellular division and growth. Concomitantly, thyroid tumors exhibit aberrant expression of numerous microRNAs, which are non-coding RNAs that inhibit expression of protein-coding genes. Employing next-generation sequencing (NGS), we revealed comprehensive miRNA profiles of normal thyroid and PTC, and identified putative novel microRNA...

ea0014oc4.4 | Neuroendocriology basis | ECE2007

Is there a role for dopamine D2 receptor gene polymorphisms in determining cabergoline sensitivity in prolactin-secreting pituitary adenomas?

Filopanti Marcello , Barbieri Anna Maria , Angioni Rita , Lania Andrea , Mantovani Giovanna , Spada Anna , Beck-Peccoz Paolo

Dopamine agonist cabergoline (CB) is the first-choice treatment in prolactin-secreting adenomas (PRL-omas). It is effective in reducing PRL secretion and tumour size in about 90% of patients by binding dopamine D2 receptor (DRD2). Although no mutations in DRD2 were found, it has been reported that several polymorphisms of this locus associate with alcoholism and schizophrenia, diseases in which dopaminergic system plays an important role. To assess the possible asso...

ea0014p553 | (1) | ECE2007

Growing incidence of idiopathic isolated secondary adrenal insufficiency.

Kasperlik-Zaluska Anna , Czarnocka Barbara , Papierska Lucyna , Bensing Sophie , Hulting Anna , Crock Patricia

Objective: The origin of idiopathic isolated secondary adrenal insufficiency (IISAI) is uncertain, however autoimmunity seems to be the most probable cause. Within last eight years the initial number of about 100 such cases, increased in our registry by 250%. We searched for features of autoimmune diseases in our group of patients to prove autoimmune etiology in a majority of these patients.Materials and methods: The material consisted of 260 patients wi...

ea0013s46 | Management of endocrine disorders in pregnancy: the mother and the child | SFEBES2007

CAH – pregnancy and antenatal glucocorticoid treatment

Lajic Svetlana , Nordenström Anna , Hirvikoski Tatja , Wedell Anna , Ritzén Martin

In foetuses at risk of virilising CAH, prenatal treatment can be offered by administration of dexamethasone (DEX) via the mother in order to prevent genital malformations. Accumulating evidence from animal studies and epidemiological data raise concerns regarding the long term consequences of excess glucocorticoids on the developing foetus. The European study PREDEX is organized as an open, controlled, non-randomised, multicentre trial. The impact of DEX on the general well-be...