Endocrine Abstracts

Background: Pheochromocytoma (PHEO) and paraganglioma (PGL) of abdominal origin secrete catecholamines which are metabolized to metanephrines. Head-and-neck paraganglioma (HNPGL) are considered as non secretary tumors.Objectives: To find the utility of plasma free metanephrine (MN), normetanephrine (NMN) and 3-methxytyramine (3-MT) for the differential diagnosis PHEO/PGL after excluding MEN2 and VHL patients.Methods: A total of 79 ...

Aim: Following the general concern regarding the association between various diabetes treatments and cancer risk, the present study evaluated the cancer specific mortality in adult insulin-treated diabetes patients.Materials and methods: All diabetes patients residing in a major urban area, aged over 40 years and receiving insulin treatment were included at the moment of their first diabetes outpatient visit from 01/01/2001 to 12/31/2008. A total of 1136...

Introduction: The prevalence of obesity in children and adolescents has dramatically increased over the last 20–30 years.Childhood overweight is associated with higher risk of obesity into adulthood and a higher incidence of metabolic consequences.Objectives: To identify the prevalence of metabolic complications in obese children and adolescents.Methods: One thirty-two obese children and adolescents (age...

Clinical caseIntroduction: Insulinoma is a rare disorder with an estimated incidence of 1 case per 250 000 people per year.Case report: 37 years old female, with a history of irritable bowel syndrome, dyslipidemia and kidney stones. In December 2010, she developed a headache, dizziness and visual disturbances, predominantly in the evening and amnesia for some of the episodes. Initially interpreted as peripheral vertiginous syndrome, because of recurrence...

Objective: To investigate the impact of dietary intervention of advanced glycation end products (AGEs) intake on hormonal and metabolic profile in women with polycystic ovary syndrome (PCOS).Methods: After baseline evaluation, 23 women with PCOS (mean±S.D., age: 23.4±5.7 years; body mass index (BMI): 26±5.7 kg/m2) underwent the following consecutive 2-month dietary regimens: a hypocaloric diet with ad-libitum</...

Polycystic ovary syndrome (PCOS) is a heterogeneous condition affecting 5–10% of reproductive -age female population.The aim of this study was to determine the clinical features, metabolic and hormonal profile in obese and overweight women with PCOS.Patients and method: A total of 102 women (age 31.28±6.05 and BMI 33.02±5.93) with PCOS and 110 (age 32.35±4.96 and BMI 33.05±5.87) matched controls were invest...

Data about the entire sperm DNA methylome are limited to two sperm donors whereas studies dealing with a greater number of subjects focused only on a few genes or were based on low resolution arrays. This implies that information about what we can consider as a normal sperm DNA methylome and whether it is stable among different normozoospermic individuals is still missing. The definition of the DNA methylation profile of normozoospermic men, the entity of inter-individual vari...

Introduction: Most paediatric medicines have not undergone extensive clinical trials in children and as a necessity are frequently prescribed off-label, a practice which is recognised to be associated with an increased risk of adverse drug reactions (ADRs).Aims: To assess the use of routinely acquired healthcare data to identify medication utilisation and specifically drug discontinuation, as a signal for possible ADR occurrence in children: using orlist...

Introduction: The risk for the development of germ cell tumors is hard to predict in patients with disorders of sex development (DSD) and their optimal management has been a continuous matter of debate. The risk varies between unknown and 40–60% in Denys-Drash/Frasier syndrome. This malignant potential opposes itself firmly to the recent interest in a more conservative approach regarding gonadectomy.Case presentation: We present the case of a 20-yea...

Prader-Willi is a complex genetic syndrome with characteristic phenotype, obesity, hyperphagia, and endocrine hypothalamic dysfunctions. We present particular features of a case with confirmed Prader Willi syndrome (PWS).Case report: EP, only child of a young non-consanguine couple, was born in 1994 at 34 weeks of amenorrhoea, with a low Apgar score (7) and a weight of 2200 g. She presented important hypotonia in the first 6 weeks of life, needing gavage...