Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep1085 | Endocrine tumours | ECE2015

Insulinoma: a multicentre and retrospective analysis of the Spanish experience during three decades

Iglesias Pedro , Lafuente Christian , Almendra Maria Angeles Martin , Lopez-Guzman Antonio , Castro Jose Carlos , Diez Juan Jose

Objective: To characterise insulinoma diagnosed and treated in the period 1983–2014 in various hospitals in Spain.Methods: Inclusion criteria were the presence of biochemical and morphological criteria compatible with insulinoma and/or histologic demonstration of tumour.Results: Twenty-nine patients (23 women (79.3%); mean age 48.7±17.4 years (range, 16–74)) were recruited. In 26 (89.7%) cases the tumor was sporadic ...

ea0037ep1188 | Clinical Cases–Pituitary/Adrenal | ECE2015

Ipilimumab-induced hypophysitis in cancer patients

Lafuente Christian , Arcano Karina , Guerrero Fernando , Marengo A , Peiro I , Soria Ainara , Diez Juan Jose , Villabona Carlos , Iglesias Pedro

Context: Ipilimumab is a human monoclonal antibody against cytotoxic T lymphocyte antigen-4 (CTLA-4), which enhances stimulation of cytotoxic T lymphocytes, resulting in an immune response against the tumour. This drug-induced hyperactivity of the immune system can lead to serious adverse effects including endocrine disorders such as autoimmune hypophysitis, thyroiditis and adrenal insufficiency.Objective: To report our experience on ipilimumab-induced h...

ea0037ep1296 | Clinical Cases–Thyroid/Other | ECE2015

Radioguided excision of occult metastatic lesion in thyroid carcinoma: a safe technique for previously operated neck in two patients

Martins Teresa , Azevedo Teresa , Santos Jacinta , Rodrigues Fernando , Rovira Eugenia , Oliveira Sofia , Neto Joao , Neves Antonio , Gilde Patricia , Cruz Carlos

Introduction: Intraoperative identification of neck lesions in patients who have undergone previous neck surgery is particularly difficult, because of operative scarring and distorted anatomy. Radioguided occult lesion localisation (ROLL) involves the preoperative intratumoral ultrasound-guided injection of a radioactive tracer. In the present study, we investigated the efficacy of roll in two patients with papillary thyroid cancer (PTC) who underwent previous neck exploration...

ea0035p670 | Growth hormone IGF axis basic | ECE2014

Young female with acromegaloid features, pituitary macroadenoma, and an uncomplicated pregnancy

Figueroa Carlos , Santiago Monica , Hernan Jose , Mangual Michelle , Gutierrez Madeleine , Palermo Coromoto , Trinidad Rafael , Sanchez Alfredo , Miranda Maria DeLourdes

Thirty-two years old female G2P1A0 seen at our endocrinology clinic 9 years ago complaining of persistent menstrual irregularities associated to elevated prolactin values. MRI done revealed a pituitary microadenoma. However, she refused treatment for microprolactinoma. Four years afterwards, patient return complaining of recurrent episodes of headache. Repeated MRI showed a pituitary macroadenoma, so start on cabergoline treatment.Once more, patient was ...

ea0070oc5.1 | Thyroid | ECE2020

TSH-Independent upregulation of thyroid-specific gene expression in dehal1 knockout mice

Alikhani Pouya , Gonzalez-Guerrero Cristian , Liao Xiao-Hui , Borsò Marco , Peluso Teresa , Zucchi Riccardo , Refetoff Samuel , Moreno Jose Carlos

Background: Most thyroid specific genes are transcriptionally regulated by TSH-TSHR signalling and T4-driven negative feedback of TSH secretion at the pituitary. However, local autoregulation of transcription has been described from IGF-IGFR, follicular thyroglobulin, or iodine. We aimed to investigate the TSH dependency of thyroid transcriptional regulation in the Dehal1 knockout, devoid of iodide-recycling capacity from iodotyrosines.Methods: ...

ea0070aep48 | Adrenal and Cardiovascular Endocrinology | ECE2020

Early renin recovery after adrenalectomy in patients with aldosterone-producing adenoma - a longitudinal study.

Mermejo Livia M , Elias Paula CL , Molina Carlos AF , Tucci Silvio , Antonini Sonir R , Castro Margaret , Moreira Ayrton

Background: Low plasma aldosterone after adrenalectomy due to aldosterone-producing adenoma (APA) and postoperative hypoaldosteronism recovery have been well described. However, prospective time course comparing simultaneously aldosterone and renin levels is still lacking.Aim: We prospectively studied clinical and biochemical findings emphasizing aldosterone and renin levels, in a cohort of patients with APA who underwent adrenalectomy in a single tertia...

ea0070aep169 | Bone and Calcium | ECE2020

Fracture risk in patients with acute poliomyelitis‏ going through late adulthood

Mamlok Sherf Rutie , Cantrell Dror , Or Keren , Marcus Efrat , Benbassat Carlos , Ish Shalom Sofia , Shapira Alex , Koren Ronit

Objective: While osteoporotic fractures are reported in up to 40% of post-poliomyelitis adults, clinical guidelines regarding bone mineral density (BMD) testing and best timing for initiating treatment in this population are scarce. We assessed the characteristics of post-poliomyelitis patients, focusing on fracture and osteoporosis as the primary outcomes.Methods: We conducted a cross-sectional retrospective data analysis from medical records of 204 pos...

ea0070aep438 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Clinical differences between patients with new-onset diabetes and those without it in a cohort of individuals with pancreatic cancer

Silva Vaca Carlos , Males David , Martin Gonzalez Alba , García Elena , Martínez Guillermo , León Miguel

Background: Pancreatic Cancer (PC) is uncommon; however, it is one of the most deadly cancer types of all. New-onset diabetes (NOD) is associated with a higher risk of pancreatic cancer than general population, particularly if late-onset. An association between new-onset diabetes and increased mortality in patients with pancreatic cancer has been suggested but clinical relevant differences between those individuals with new-onset diabetes and those without are not well establi...

ea0070aep498 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Evolution of comorbidities associated with obesity one year after bariatric surgery, our hospital experience

de Carlos Joaquin , Anda Emma , Zugasti Ana , Petrina Estrella , Marí Amelia , Rendón Henry , Botella Sonsoles

Bariatric surgery (BS) improves quality of life and health due to the beneficial effect on the metabolism at multiple levels. Specifically, its effectiveness in weight loss and the attenuation or resolution of comorbidities associated with obesity, means lower morbidity and mortality compared to other types of interventions. The objective is to analyze the evolution of obesity-related diseases after twelve months of follow-up.Methods: Retrospective study...

ea0070aep830 | Reproductive and Developmental Endocrinology | ECE2020

Anti-müllerian hormone (AMH) as the primary marker for ovarian reserve in transgender male, with or without pcos, under cronic testosterone treatment

Modrego Pardo Ines , Gómez Balaguer Marcelino , Garzón Pastor Sandra , Morillas Ariño Carlos

Background: AMH represents a marker of ovarian reserve and is used in monitoring the effects of gonadotoxic drugs. In PCOS is higher and is an indirect marker of hyperandrogenism. In transsexual man(TM), high prevalence of PCOS is described and AMH provide information about ovarian reserve after exposure to testosterone.Objective: To assess the prevalence of PCOS in young TM previously to testosterone treatment, study the evolution of AMH levels and diff...