Searchable abstracts of presentations at key conferences in endocrinology

ea0052p02 | (1) | UKINETS2017

Validation of a blood biomarker test for the diagnosis and management of bronchopulmonary neuroendocrine tumors

Modlin Irvin , Kidd Mark , Lewczuk Anna , Chung Kjung-Min , Kolasinska-Cwikla Agnieska , Cwikla Jaroslaw , Lowczak Anna , Doboszynska Anna , Tesselaar Margot , Buikhuisen Wieneke , Malczewska Anna , Kos-Kudla Beata , Roffinella Matteo , Filosso Pier Luigi , Korse Tiny , Papotti Mauro , Bodei Lisa , Drozdov Ignat

Background: There is currently no effective blood biomarker for lung neuroendocrine neoplasia diagnosis and management. We describe the clinical utility of a 51 neuroendocrine-specific gene expression set in blood to diagnose bronchopulmonary neuroendocrine tumors (BPNETs) and define their clinical status.Methods: The discovery set included BPNETs (n=154) and controls (n=90), randomly assigned (1:1) to a test and validation set. Specifi...

ea0081rc3.6 | Rapid Communications 3: Thyroid 1 | ECE2022

The mRNA of fibronectin 1 and of the integrin subunit alpha V are powerful prognostic indicators in papillary thyroid carcinoma

Vitale Mario , Marotta Vincenzo , Tortora Anna , Izzo Giulia , Rocco Domenico

Integrins are cell-extracellular matrix adhesion molecules considered functionally related to the development of cancer metastasis. Starting from the dataset of mRNA-seq of papillary thyroid carcinoma (PTC) from the TCGA, we determined the expression of fibronectin 1 (FN1) and fibronectin-binding integrins in PTC. We then analyzed the association of the expression of these two genes with the driver genes, the stage of the disease and its outcome. 355 PTCs and 58 normal thyroid...

ea0081p714 | Reproductive and Developmental Endocrinology | ECE2022

Serum concentrations of 17-hydroxyprogesterone and dehydroepiandrosterone sulfate in women with polycystic ovary syndrome and their relation to the parameters of glucose metabolism

Stogowska Ewa , Krentowska Anna , Adamska Agnieszka , Lebkowska Agnieszka , Kowalska Irina

Introduction: Polycystic ovary syndrome (PCOS) is characterized by menstrual disorders, hyperandrogenism and polycystic ovaries on ultrasonography. This hormonal disorder is also strongly associated with insulin resistance. The diagnosis of PCOS can be established after the exclusion of other causes of mentioned symptoms, such as non-classic congenital adrenal hyperplasia (NCAH). To date, several studies suggest the increased serum concentration of 17-hydroxyprogesterone (17-O...

ea0081ep4 | Adrenal and Cardiovascular Endocrinology | ECE2022

Clinical-laboratory and morphological predictors of pheochromocytoma progression

Motrenko Anna , Britvin Timur , Ilovayskaya Irena , Gurevch Larisa

According to the 4th edition of the WHO classification of endocrine organ tumors (2017), all pheochromocytomas are classified as malignant tumors (ICD-O code 8700/3). However, in the literature there are no unambiguous data on the significance of clinical and laboratory predictors of the aggressiveness of pheochromocytoma. The aim of the study was to verify possible predictors of pheo-progression using clinical data, the results of laboratory and instrumental examination (incl...

ea0081ep24 | Adrenal and Cardiovascular Endocrinology | ECE2022

Complex adjuvant treatment of patients with two-component adrenocortical cancer (clinical case)

Krivosheev Alexey , Britvin Timur , Motrenko Anna , Gurevch Larisa , Ilovayskaya Irena

Adrenocortical cancer (ACC) is a tumor of the adrenal cortex, clinical manifestations, recurrence, and progression potential are determined by its biological characteristics. Morphological diagnosis of tumors of the adrenal glands in some cases presents significant difficulties. According to the WHO classification of tumors of the endocrine organs (4th revision, 2017), in addition to the classical one, myxoid, sarcomatoid and oncocytic histological variants of ACC are distingu...

ea0081ep132 | Calcium and Bone | ECE2022

Association of preoperative therapy by native form vitamin D and hypocalcemia after parathyroidectomy in primary hyperparathyroidism patients

Elfimova Alina , Eremkina Anna , Rebrova Olga , Kovaleva Elena , Mokrysheva Natalia

Background: Primary hyperparathyroidism (PHPT) is a common endocrine disorder resulting from oversecretion of parathyroid hormone (PTH) in parathyroid glands. Hypocalcemia can occur in the postoperative period after parathyroidectomy (PTE) and can be challenging to control and requires varying doses of supplementation. Vitamin D deficiency can worsen the severity of PHPT and promote the development of “hungry bone syndrome” due to increased influx of calcium into bon...

ea0081ep146 | Calcium and Bone | ECE2022

Quality of life in chronic hypoparathyroidism on conventional treatment

Gins Nikolay , Elfimova Alina , Kovaleva Elena , Eremkina Anna , Mokrysheva Natalia

Introduction: Reduced health-related quality of life (HRQoL) is common in patients with hypoparathyroidism (HypoPT) treated conventionally with calcium and active vitamin D supplements.Aim: we studied the HRQoL in patients with chronic HypoPT estimated with the 36-Item Short-Form Health Survey (SF-36) and multidimensional fatigue inventory (MFI-20).Methods: 64 patients with chronic HypoPT (women/men – 57/7, median age 47[36;59...

ea0081ep156 | Calcium and Bone | ECE2022

Late diagnosis of life-threatening hypocalcemia in a patient with hypoparathyroidism after hemithyroidectomy: A case report

Maghakyan Sona , Vardanyan Anna , Ghazaryan Ara , Aghajanova Elena

Introduction: Hypocalcemia is defined as a decreased level of calcium in the blood. The presentation of hypocalcemia varies widely, from asymptomatic to life-threatening. The most common cause of chronic hypocalcemia is postsurgical hypoparathyroidism. This may occur after removal of all parathyroid tissue during thyroidectomy and radical neck dissection for malignancies or after inadvertent interruption of the blood supply to the parathyroid glands during head and neck surger...

ea0081ep273 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Serum xanthinoxidase activity (sxo)-glucose homeostasis association in patients with type 2 diabetes mellitus (t2dm)

Khyzhnyak Oksana , Cherniaieva Anna , Mykytyuk Myroslava , Karachentsev Iurii

Introduction: Hyperuricemia is increasingly being considered a potential pathogenic factor for T2DM, metabolic syndrome, and several adverse consequences of vascular disease. It has been suggested that xanthine oxidase may underlie the urine acid-T2DM association. The study aimed to determine the associations between clinical parameters, glucose homeostasis, and SXO activity in patients with T2DM.Methods: 125 patients with T2DM, age (58.9±9.4) years...

ea0081ep285 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Predicting the effectiveness of metformin in patients with type 2 diabetes mellitus from molecular genetic positions

Sorokina Yulia , Sukhanov Sergey , Zanozina Olga , Mosina Anna

Purpose: to assess the possibility of predicting the effectiveness of pharmacotherapy with metformin in patients with type 2 diabetes mellitus (DM2) depending on the single nucleotide polymorphism of the nitric oxide synthase gene.Materials and methods: 186 patients were examined, referred for planned hospitalization, the duration of DM2 was 6-8 years, the target level of glycated hemoglobin was 7.5%, the actual level was 8.3%. All patients were prescrib...