Endocrine Abstracts

Background: In 2016, a prospective study conducted by our team found a prevalence of 7.7% of pheochromocytomas (Pheo) in patients with neurofibromatosis type 1 (NF1) if systematic screening including free metanephrines measurement (DMX) and abdominal imaging was performed. Half of Pheo were secreting, with 16% being symptomatic. This suggested the benefit of a systematic screening by abdominal imaging and DMX assay. The objective of this study was to evaluate the impact of sys...

Background/objective: mETE has shown no effect on survival, and the 8th edition of the AJCC classification no longer considers mETE in the pT3 definition. Therefore, tumors with mETE below 40 mm are now staged pT1/pT2. However, controversy remains regarding mETE impact on disease recurrence. This study assessed the risk of recurrence of PTC patients previously classified as pT3 because of mETE, compared to PTC patients staged pT1-pT2.Methods: Monocentric...

The thyrotroph tumors or pituitary neuroendocrine tumors (PitNET) classify as tumors of Pit-1 family. These tumors are rare and may be monohormonal, secreting only TSH, or plurihormonal, secreting TSH-GH±PRL, with or without acromegaly. The objectives of this retrospective study were to confirm the frequency of the plurihormonal subtype and to compare the clinical, biological and pathological characteristics of these two pathological subtypes. We retrospectively studied t...

Context: Multiple Endocrine Neoplasia type 1 (MEN1) is an autosomal dominant disease caused by mutations in the MEN1 gene. MEN1 is characterized by a broad spectrum of clinical manifestations, of which the most frequent are primary hyperparathyroidism, pituitary adenomas, and neuroendocrine tumors. MEN1 presents a broad spectrum of variants, including large deletions, and truncating, missense, or splicing point mutations. The genotype-phenotype relationship r...

Bone radioiodine (RAI) uptake without structural abnormality in thyroid cancer (TC) patients may be related to false positive or to microscopic foci of metastatic tissue. In such cases, outcome is reported to be excellent. Mrs D. had been operated for a pT3(m) poorly differentiated TC at the age of 43. The first post-therapeutic whole body scan revealed 3 foci of bone uptake (right clavicle, L2, L3). The elevated level of thyroglobulin (157 ng/mL) favoured the hypothesis of bo...

Background: Octreotide s.c. depot is a novel, ready-to-use formulation administered via a thin needle, which may allow self-administration. In a phase 1 study in healthy volunteers, octreotide s.c. depot provided greater bioavailability with faster onset and greater IGF1 suppression than long-acting octreotide. Here, we present data from a phase 2 study evaluating pharmacokinetics (PK), efficacy, safety, and tolerability of octreotide s.c. depot in patients with acromegaly and...

Thyroid nodules are very common and benign in most cases. Thus, malignancy detection avoiding overtreatment is a challenge. Nodule evaluation mainly supports on US and fine needle aspiration cytology (FNAC). The Bethesda classification (BC) for reporting thyroid cytopathology is now currently used for the interpretation of results but it does not enable classifying 30% of samples.The objective was to identify, by transcriptome analysis, a molecular signa...

Context: Somatostatin receptor type 5 (SST5) is inconsistently expressed by corticotroph tumors, with higher expression found in corticotropinomas having ubiquitin-specific protease 8 (USP8) mutations.Aims: To study the correlation between characteristics of corticotropinomasand SST5 expression/USP8 mutation status; to describe the response to pasireotide in 5 patients.Design: Retrospective cohort study.Metho...

Background: The increasing age of the general population represents a new challenge for endocrinologists and caregivers since it is well know that the occurrence of thyroid dysfunction increases with age. It is still controversial whether or not reference values of thyrotropin (TSH) adapted to age and sex need to be used. Herein, we aimed to determine reference intervals, in males and females, suitable for thyroid disease exploration and follow-up during adult life in a tertia...

Background: Conventional therapy for chronic hypoparathyroidism (cHP) is often unable to maintain stable normal serum calcium (Ca) levels for a full 24 h, to control symptoms, to prevent the detrimental long-term effects on the kidney and to preserve normal bone architecture. Eneboparatide (AZP-3601) is a novel 36-amino-acid peptide specifically designed to activate the R0 conformation of the PTH receptor 1, that results in a prolonged calcemic response and a sustai...