Endocrine Abstracts

Objective: According to recent studies, impaired secretion of GH is a frequent finding after ischaemic stroke. The aim of our study was to compare various available GH stimulation tests in post-stroke patients.Design: Seventeen patients were included in the study (12 males; mean age: 60.5 years; mean BMI, 27.7 kg/m2) with a mean 19.6 (±7.3) months after stroke. For screening, glucagon and small dose (0.15 μg/kg) GHRH-arginine (sdGHRH...

Background: The detectable levels of thyroid antibodies in patients suffering from Riedel’s chronic fibrosing thyroiditis (RT) suggest a link between RT and Hashimoto’s thyroiditis, but the pathogenesis of RT is not really known. Lyme disease is the most frequent tick-borne infection with variable manifestations in different organs caused by Borrelia burgdorferi (Bb).Case report: A 59-year-old woman presented in our outpatient clinic wit...

Twelve years following hemicolectomy for colon adenocarcinoma, a 75-year-old patient with prostate cancer was treated for 4 weeks with the antiandrogen nilutamide and then with the long-acting GnRH agonist buserelin. The serum testosterone and prostate-specific antigen (PSA) levels had decreased dramatically after 3 months of treatment. After 2 years of buserelin administration, the hormonal state was examined. Serum estradiol, testosterone, DHEA, DHEAS, FSH and LH levels prov...

Background: Widespread use of imaging has led to the detection of an increasing number of thyroid nodules. Thyroid societies have recommended the use of Thyroid Imaging, Reporting and Data System (TIRADS). However, there is a multitude of such risk stratification systems (RSS) for selecting thyroid nodules for FNA. They may be time consuming and consensus on thyroid nodule descriptors lacks. Also studies have suggested that operators’ experience may not be inferior to usi...

Angiotensin II (AngII) is an octapeptide hormone, which participates in physiological and pathological mechanisms. AngII exerts a number of biological effects through the type 1 angiotensin II receptor (AT1R). One of the main targets of AngII are vascular smooth muscle and its stimulation activates numerous signaling pathways that cause contraction and could also result in gene expression changes in vascular smooth muscle cells (VSMCs). Next-generation sequencing (NGS) experim...

Background: Since their FDA-approval in 2018, both Lu177-DOTATATE and I131-MIBG radiopharmaceutical therapies are available at our institution for the treatment of pheochromocytoma and paraganglioma (PPGL). Tumor uptake of the radiopharmaceutical on pre-therapy imaging is a requirement for treatment. Here, we describe our experience with pre-therapy imaging, and how it relates to the tumor genotype and the therapeutic choice.Methods: This is a retrospect...

Angiotensin II (AngII) is a vasoactive peptide hormone and the effector of the renin-angiotensin-aldosterone system. It exerts its main physiological effects through type 1 angiotensin II receptor (AT1R), but it can also contribute to the development of cardiovascular diseases. Likewise, oxysterols such as 25-hydroxycholesterol (25-HC), the product of cholesterol-25-hydroxylase (CH25H), can have harmful effects on the vasculature since they affect vascular smooth muscle cells ...

Objective: Tumors of the pituitary gland and sellar region, called pitiutary adenoma (PA) represent approximatly 10% of all central nervous system tumors. The characteristics of these tumors may vary from population to population.Aim: The aim of this retrospective study was to investigate and understand the clinicopathological characteristics, the invasiveness, tumor features and clinical symptoms of PA in adult patients at south great plain region of Hu...

: Thyroid cancers represent approximately 1% of new cancer diagnoses. Thyroid malignancies are divided into papillary carcinomas (80%), follicular carcinomas (10%), medullary carcinomas (5–10%), anaplastic carcinomas (1–2%) other rare tumours (primary thyroid lymphomas, primary thyroid sarcomas). The main therapeutic options are surgery (mainly total thyreoidectomy), radioiodine treatment (depending on the type and stage of the tumour), levothyroxine therapy (thyroid...

The case: The multiplex endocrine neoplasia 2A (MEN2A) syndrome is a monogenic disease caused by mutation of the RET protooncogene leading to medullary thyroid cancer (MTC), pheochromocytoma and primary hyperparathyroidism. The specific mutations determine the timing of the preventive thyroidectomy. In 2007, in a 26 year old female patient, after detailed endocrine investigation, total thyroidectomy with both sided lateral neck lymph node dissection was performed because of su...