Endocrine Abstracts

Introduction: Normal or elevated TSH level in the presence of elevated T4 is defined as ‘inappropriate TSH syndrome’. Two main clinical conditions that can lead that syndrome are TSH-secreting adenoma (TSHoma) and resistance to thyroid hormone (RTH). Making the correct diagnosis is crucial in order to decide the most appropriate treatment option. Herein we presented clinical and laboratory data of seven patients who were hospitalised for the differential d...

Introduction: Major factor that modulates the PTH secretion is serum Ca level. Paratyhyroid gland also receives direct autonomic innervation. To date, measurement of several hormones such as cortisol,prolactin, renin and aldosteron were found to be affected by changing the posture from recumbent to the upright position. In the present study, we aimed to investigate postural change of PTH in normal individuals and patients with primary hyperparathyroidism (PHPT).<p class="a...

Introduction: Adrenal failure due to tuberculosis is rarely seen nowadays. There are few reports in the literature suggesting that adrenal insufficiency may improve with anti-tuberculosis therapy during the active phase of the disease. Herein, we presented a case of reversible adrenal failure in a patient with active tuberculosis.Case report: A 50-years-old-female patient admitted to our clinics with the complaints of weakness and darkening of the skin. ...

Background: Diabetic retinopathy (DR) is the leading cause of blindness in the world. Retinopathy and nephropathy can still progress in diabetics despite optimal metabolic control. The aim of the present study was to determine whether different degrees of DR (proliferative or non-proliferative) were associated with abnormally modulated hemostatic parameters in patients with type 1 DM.Method: 52 type 1 diabetic patients and 40 healthy controls were enroll...

Introduction: Diabetic nephropathy (DN) is an important one of the complications and is detected in almost 30-40% of the patients with type 1 diabetes mellitus (T1DM). Besides the well known risk factors, endothelial dysfunction also plays a role in the pathogenesis of DN and diabetic retinopathy. Our aim was to determine flow mediated dilation measurements and serum soluable ET-1, ICAM-1, and VCAM-1 levels in T1DM patients with or without inceased albumin excretion and compar...

Background: PCOS is one of the most common disorders affecting at least 5–10% of women of reproductive age. Increased prevalance of autoimmune thyroiditis and goiter were reported in PCOS patients. This study investigated the prevalance of hypothyroidism, thyroid autoimmunity, ultrasonographic features and presence of nodules in PCOS patients and compare them with the control group. We also aimed to detect correlation of thyroid volume (TV) with serum IGF1 levels in patie...

Giant cell granuloma is a skeletal manifestation seen now rarely in hyperparathyroidism due to early recognition of the disease. Lesions usually occur in the areas of intense bone resorption. They can affect mandible, maxilla, clavicle, ribs and pelvic bones. Most of the patients who have primary hyperparathyroidism are asymptomatic and are discovered incidentally during laboratory examinations. Here, we represent a female patient who was referred to endocrinology clinics beca...

The classic clinic manifestation of primary hyperparathyroidism (PHPT) is osteitis fibrosa cystica, a severe skeletal disease characterized by brown tumors, bone cysts and deformities, due to extremely elevated bone resorption elicited by continuously high parathyroid hormone (PTH) levels. In cardiovascular system there may be shortened QT interval, deposition of calcium in heart valves, coronary arteries, and myocardial fibers. Here, we report a case with PHPT, who have anore...

Pituitary adenomas which co-secrete GH and TSH accounts for <0.2% of all adenomas of the pituitary. Symptoms of hypertyroidism are usually masked by clinical manifestations of acromegaly. Here, we have reported the result of the primary one year long medical therapy in a case who was diagnosed to have adenoma co-secreting GH and TSH.Case: Seventy-years-old female patient has admitted with the complaints of excessive sweating, enlargement of hands and...

Well-known environmental factors which can lead to type 1 diabetes are viral infections, vaccines, diet, exposure to cow milk in infancy, vitamin D deficiency, drugs, maternal age, preeclampsia and low birth weight. Isotretinoin is an effective drug for acne treatment. It can cause dyslipidemia, elevated liver enzymes, insulin resistance and type 2 diabetes. Our case is type 1 diabetes developed after the use of isotretinoin and represented with diabetic ketoacidosis.<p cl...