Endocrine Abstracts

Introduction: Acute cardiac insufficiency induced by stress (Takotsubo cardiomyopathy (TTC)) is a reversible cardiomyopathy induced by severe emotional stress or severe clinical conditions. It is characterised by transient left ventricular systolic dysfunction and electrocardiographic changes. This cardiomyopathy has been described in some severe neurological conditions and in patients with pheochromocytoma. To date, some cases of this cardiomyopathy have been described in pat...

Introduction: Neurohormonal diabetes insipidus (DI) is a rare disorder caused by partial or total vasopressin deficiency which results in diluted urine characterized by polyuria and polydipsia. In 30–50% of the cases the cause of the disease is unknown; it is the so-called idiopathic diabetes insipidus. Other causes include: tumors of the CNS most commonly craniopharyngioma, pituitary macroadenomas, central nervous system trauma, inflammatory state of hypothalamus or pitu...

Objective: The cross-sectional study was designed to assess the psychosocial profiles of patients with acromegaly and with non-functioning adenomas in correlation with the severity of the diseases.Methods: Forty-one patients with acromegaly and thirty-one with non-functioning adenomas underwent a cross-sectional assessment regarding their socio-demographic and medical profiles, including the quality of life, psychiatric morbidity, and acceptance of illne...

The lifelong exposure to mixtures of endocrine disrupting chemicals raises serious concerns about their deleterious effects on human health. Polychlorinated biphenyls (PCBs) had widespread use in numerous industrial applications, and were massively produced for several decades. After the discovery of the adverse effects of PCBs in the 1970s, brominated flame retardants (BFRs) were established as the major chemical flame retardant. Both chemicals persist in the environment and ...

Sixteen percent of parathyroid adenomas can be situated in an ectopic location. Ectopic parathyroid glands result from aberrant migration during early stages of development, and lack of successful identification may lead to lack of success in parathyroid surgery. These glands are most frequently found in the anterior mediastinum, in association with the thymus or the thyroid gland. Ectopic parathyroid glands are a major cause of persistent and recurrent hyperparathyroidism.</p...

Introduction: Hepcidin is an acute-phase protein and a key regulator of iron homeostasis. Anemia frequently occurs in patients with hyperthyroidism, while hepcidin may be a potential link.Objectives: Prospective evaluation of hepcidin serum concentration and other parameters related to Fe homeostasis in group of hyperthyroid patients in the course of Graves’ disease (GD) at diagnosis and after restoration of euthyroidism.Pati...

Introduction: Subclinical hypothyroidism (sHT) is defined as elevated level of TSH with normal levels of thyroid hormone. In obese children there is a high frequency of this disturbance. However, the influence of sHT on therapy success and an appearance of metabolic complications in childhood obesity is unclear. Furthermore, the supplementation L-thyroxin (L-T4) in this case seems to be very controversial.Aim: The...

What happens if the prescribed medication makes the patient ‘worse’ than he was before comint to the doctor? Putting aside the world wide accepted JNC clasiffication of hypertension, we colud consider the following:The ‘cat-walk’ (moderate) hypertension (<150/95 mmHg) 2. Pts with serious hypertension with symptoms 3. Pts with seerious hypertension without symptoms.Having moderate hypertension and no side eff...

Hyperprolactinemia may lead to bone loss, both due to hypogonadism and other hormonal disturbances.Aim: Aim of the study was the analysis of influences of hormonal profiles associated with hyperprolactinemia on bone mineral density (BMD) and bone turnover in women with hyperprolactinemia of various origin. The subjects were 32 patients with prolactinoma, 43 ones with functional hyperprolactinemia and 29 healthy controls. All of them were studied BMD (lum...

The role of ghrelin in the pathogenesis of acromegaly is doubtful. Ghrelin also regulates glucose and adipose tissue metabolism. It has not been demonstrated whether it contributes to the development of metabolic complications of acromegaly.Aim: The aim of the study was to assess: (1) whether serum concentrations of total and acyl ghrelin in patients with acromegaly differ in relation to coexisting metabolic complications (hypercholesterolemia, hyperinsu...