Searchable abstracts of presentations at key conferences in endocrinology

ea0029p781 | Endocrine tumours and neoplasia | ICEECE2012

Hepatocellular carcinoma (HCC) as a neuroendocrine tumor: a preliminar molecular study.

Pivonello C. , Vitale G. , Izzo F. , Di Sarno A. , Giorgio A. , Hofland L. , Colao A. , Pivonello R.

Hepatocellular carcinoma (HCC) is often diagnosed at late stage or metastatic condition. Surgical resection is considered treatment of choice and other treatment options include chemoembolization, radiofrequency ablation and photodynamic therapy. We evaluated the expression levels of the 5 somatostatin receptors (SSTRs) in 23 biopsies of HCC patients and also mTOR, p70S6K and 4eBP1 in HuH-7 and HepG2 and investigated the in vitro effect of somatostatin analogs (SA) and ...

ea0022oc6.2 | Bone | ECE2010

Association between serum osteocalcin and insulin sensitivity in primary hyperparathyroidism

Gianotti Laura , Tassone Francesco , Pellegrino Micaela , Baffoni Claudia , Croce Chiara Giulia , Cesario Flora , Borretta Giorgio

A regulatory role of the skeleton on glucose metabolism has been supposed both in animals and in humans. Osteocalcin (OC) seems to be involved in this regulation and has been reported to be inversely associated with insulin resistance and measures of adiposity in different populations of adult subjects. Primary hyperparathyroidism (PHPT) is a condition mostly affecting elderly subjects and characterized by both marked increased bone turnover and increased insulin resistance. T...

ea0022p665 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Transition from Cushing's disease to a hormonally inactive adenoma or vice versa: four unusual cases of corticotroph adenoma

Faustini-Fustini Marco , Zoli Matteo , Mazzatenta Diego , Pasquini Ernesto , Pia Foschini Maria , Granata Antonio , Frank Giorgio

Over the last decade 824 pituitary tumours have been removed in our centre. Of these, 114 (13.8%) were corticotroph adenomas. We present four unusual cases of corticotroph adenoma showing transition from Cushing’s disease to a hormonally inactive adenoma (case 1 and 2) or vice versa (case 3 and 4).Case 1: A 51-year-old man was admitted with a 2-year history of weight gain, arterial hypertension and chiasmatic syndrome. Cushing’s disease (CD) du...

ea0020p230 | Bone/Calcium | ECE2009

Bone mineral density among patients with primary hyperparathyroidism with or without diabetes

Tassone Francesco , Gianotti Laura , Pellegrino Micaela , Baffoni Claudia , Ghio Michela , Emmolo Ignazio , Borretta Giorgio

Introduction: The relationship between diabetes mellitus (DM) and osteoporosis is controversial. Both Type 1 DM and Type 2 DM have been associated with higher risk of fractures, whereas BMD is increased in Type 2 and decreased in Type 1 DM. In primary hyperparathyroidism (PHPT) a higher prevalence of Type 2 DM has been found but the influence of DM on BMD is unknown.Subjects and methods: In a consecutive series of 262 patients with PHPT (age, mean±S...

ea0020p531 | Paediatric Endocrinology | ECE2009

Influence of the exon 3: deleted polymorphism of the GH receptor on glucose and lipid metabolism in GH treated subjects with GH deficiency: results of a preliminary study

Baiocchi Michela , Donati Chiara , Maselli Mara , Mella Patrizia , Prandi Elena , Pilotta Alba , Radetti Giorgio , Buzi Fabio

GH has contra-insulin actions and exogenous GH can reversibly reduce insulin sensitivity in patients treated with GH. It has been recently reported that the exon 3 – deleted (d3) isoform of the GH receptor (GHR) appears to be preventive for type 2 diabetes mellitus in adult subjects (GH&IGF Res 2007;17:392). Aim of this study was to investigate possible influences of the GHR-d3 polymorohism on glucose metabolism, lipid profile and BMI in children treated with GH for G...

ea0016p12 | Adrenal | ECE2008

RNA interference inhibits VEGF and EG-VEGF expression of H295R human adrenocortical carcinoma cell line

Appolloni Gloria , Arnaldi Giorgio , Di Stefano Michele , Spegni Monica , Cardinaletti Marina , Trementino Laura , Boscaro Marco

Background: The development of a vascular supply is a critical factor in the growth and metastatic spread of malignant tumors. The recognition of the vascular endothelial growth factor (VEGF) pathway as a key regulator of angiogenesis has led to a considerable efforts to exploit its potential for therapy in oncology. Endocrine gland-derived (EG-VEGF) has been recently identified as an endothelial cell mitogen, predominantly expressed in steroidogenic tissues; it represents a n...

ea0016p26 | Adrenal | ECE2008

Glucocorticoid receptor gene polymorphisms and bone mineral density in hpa axis disorders

Arnaldi Giorgio , Appolloni Gloria , Romagni Paola , Cardinaletti Marina , Trementino Laura , Polenta Barbara , Concettoni Carolina , Boscaro Marco

Glucocorticoid receptor (GR) gene polymorphisms have been associated with interindividual variations in glucocorticoid sensitivity in healthy individuals.Aim: Aim of this study was to investigate whether there was an association with sensitivity to glucocorticoids and bone mineral density in HPA axis disorders.Methods: We analyzed 3 polymorphisms of the GR gene (Bcl1, N363S, ER22/23EK) in 185 subjects: 52 patients with Cushing&#146...

ea0016p81 | Bone and calcium | ECE2008

Predictors of bone mineral density in men with primary hyperparathyroidism

Tassone Francesco , Gianotti Laura , Pellegrino Micaela , Croce Chiara , Baffoni Claudia , Magro Gianpaolo , Cesario Flora , Borretta Giorgio

Introduction: In primary hyperparathyroidism (PHPT) bone involvement is frequent. In women with PHPT it has been previously reported that menopausal status together with PTH, calcium levels and renal function are independent predictors of bone density. In male subjects, the impact of PHPT on bone status is less defined.Aim of the study: To investigate this study was possible predictors of bone mineral density (BMD) in a series of male subjects affected b...

ea0016p125 | Clinical cases | ECE2008

Effects of gender on clinical and biochemical features in Cushing's disease

Cardinaletti Marina , Trementino Laura , Polenta Barbara , Concettoni Carolina , Mancini Tatiana , Boscaro Marco , Arnaldi Giorgio

Cushing’s disease (CD) occur more frequently in females than in males, but in men this disease seems appear at a younger age and with more severe symptoms and clinical course. Aim of this study was to compare clinical features and biochemical indices of hypercortisolism in male and female patients with CD.Methods: Forty-five patients (35 females and 10 males) with confirmed CD were analyzed. All patients underwent a complete biochemical and endocrin...

ea0016p482 | Neuroendocrinology | ECE2008

Endoscopic pituitary surgery as the primary treatment for acromegaly: a prospective study in a specialised centre

Faustini-Fustini Marco , Magrini Satima , Anagni Mascia , Mazzatenta Diego , Pasquini Ernesto , Frank Giorgio

The main aims of treatment of acromegaly are reversing symptoms and signs, removing the tumour, preventing disease recurrence, and improving survival. Increased mortality associated with acromegaly can be diminished if treatment is successful in reducing GH <2–2.5 ng/ml. We carried out a prospective study to assess whether recent advances in surgical technique (namely the endoscopic approach in a specialised centre encompassing specialist pituitary surgeons working in...