Searchable abstracts of presentations at key conferences in endocrinology

ea0015s25 | Androgen receptors - physiology and disease | SFEBES2008

Tissue-specific androgen receptor knockout models. novel tools in the study of androgen action

Verhoeven Guido , Denolet Evi , Swinnen Johannes , Saunders Philippa , Sharpe Richard , De Gendt Karel

Specific ablation of the androgen receptor (AR) in selected target cells prevents the major developmental defects inherent to generalised AR inactivation (Tfm, ARKO) and allows a detailed analysis of the contribution of defined cells and molecular pathways to more complex effects of androgens. We successfully applied this approach in the study of the role of androgens in the control of spermatogenesis, by developing a Cre/loxP-based mouse model with a Sertoli cell (SC)-selecti...

ea0056p629 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

Fibroblast growth factor-21 predicts adverse outcome in community-acquired pneumonia

Ebrahimi Fahim , Wolffenbuttel Carole , Blum Claudine A , Muller Beat , Schuetz Philipp , Christ-Crain Mirjam , Betz Matthias Johannes

Introduction: Fibroblast growth factor-21 (FGF-21) is a recently discovered hormone acting as a central regulator of metabolism via adaptation of glucose homeostasis, insulin sensitivity, and ketogenesis. While acute systemic inflammatory conditions come along with profound alterations of metabolism, the role of FGF-21 in these acute phase responses is still unknown.Methods: This is a secondary analysis of two randomized, controlled trials in patients pr...

ea0056p856 | Pituitary - Clinical | ECE2018

A first-in-human pharmacokinetic, safety, and tolerability study of pasireotide subcutaneous depot

Tiberg Fredrik , Glantz Susanne , Strandgarden Kerstin , Darstein Christelle , Eisinger Johannes , Tauchmanova Libuse , Breitschaft Astrid

Background: Pasireotide is available in twice-daily subcutaneous (sc) and long-acting intramuscular (im) formulations. Pasireotide sc depot is an investigational extended-release sc formulation designed for improved handling and administration. Results are reported from a Phase I dose-escalating study.Methods: All subjects received a single dose of pasireotide sc (600 μg) and were randomized 12:2:2 to pasireotide sc depot as a single upper-thigh inj...

ea0073aep8 | Adrenal and Cardiovascular Endocrinology | ECE2021

Zona glomerulosa derived Klotho does not regulate aldosterone synthesis in young mice

Tang Cong , Xie Ye , Scapin Alessia , Loffing Dominique , Breault David , Loffing Johannes , Beuschlein Felix

Klotho (Kl), initially identified as an antiaging gene, plays a critical role in the regulation of renal and adrenal dependent fluid homeostasis. A previous study reported that haplodeficiency of Kl in mice resulted in increased aldosterone synthase (CYP11B2) expression, elevated plasma aldosterone and high blood pressure. This phenotype was presumed to result from diminished Kl expression in zona glomerulosa (zG) of the adrenal. To examine whether Kl expressed in zG is indeed...

ea0099p227 | Adrenal and Cardiovascular Endocrinology | ECE2024

CXCR4-directed [68Ga]Ga-PentixaFor PET/CT as a diagnostic modality in subtyping primary aldosteronism

Baz Amir Hosse in Chaman , Gotthardt Martin , Spiering Wilko , Deinum Jaap , Langenhuijsen Johannes

Introduction: Primary aldosteronism (PA) is a form of secondary hypertension, affecting 2.4% of the hypertensive population. It is caused by autonomous overproduction of aldosterone by either a unilateral aldosterone-producing adenoma (APA) or by bilateral adrenal hyperplasia (BAH). Subtyping is crucial, because PA is cured by adrenalectomy in APA and is treated by medication in BAH. The reference standard in subtyping PA is adrenal vein sampling (AVS). However, it is invasive...

ea0099ep208 | Pituitary and Neuroendocrinology | ECE2024

Oral health-related quality of life in patients with acromegaly vs patients with non-functioning pituitary adenomas

Blum Sandra , Daume Linda , Illuri Rohith , Kleinheinz Johannes , Trebicka Jonel , Vorona Elena

Introduction: Acromegaly is a rare endocrinologic disease most commonly caused by an excess of growth hormone (GH) produced by a benign pituitary adenoma. Besides diverse systemic manifestations, acromegaly is also associated with a range of oral-dental problems. To date limited research has been conducted on how oral-dental pathologies affect the oral health-related quality of life (OHRQoL) in patients with acromegaly and growth hormone-producing pituitary adenomas. To our kn...

ea0101op-01-06 | Oral Session 1: Topic Highlights | ETA2024

Cut&tag reveals distinct TRA2-specific DNA binding profiles in HIPSC-derived cardiomyocytes

Harting Nina , Ludwik-Shah Katarzyna , Stachelscheid Harald , Surowy Harald , Kilpert Fabian , Koster Johannes , Kaiser Frank J.

Objective: Thyroid hormone receptors (TRs) are important ligand-dependent regulators of thyroid hormone target gene expression. In contrast, the role of TRα2, a thyroid hormone receptor α splice variant that is unable to bind thyroid hormones, remains enigmatic for more than 30 years. However, its evolutionary conservation in eutherian mammals and high expression levels in some cell types as well as under ‘pathological conditions’ such as heart failure stro...

ea0101ps2-19-04 | TED | ETA2024

Analytical performance of a novel bioassay for blocking thyrotropin receptor antibodies

George Augustine , Lotz Johannes , Bossowski Artur , Ganz Anna-Lena , Wolf Jan , Kahaly George

Background: Blocking thyrotropin receptor (TSH-R) autoantibodies (TBAb) are present in 10-15% of patients with autoimmune thyroid disease (AITD). TBAb are functional and affect thyroid function. Analytical performance of a novel bioassay for TBAb was evaluated.Methods: Serum samples from AITD patients were tested with a CE market cell-based TBAb blocking reporter bioassay (Thyretain®, Quidelortho, USA) with expression of a Luciferase transgene as re...

ea0020p552 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

The D3 GH receptor polymorphism is associated with osteoarthritis, especially of the hip, in patients with long-term cured acromegaly

Wassenaar Moniek JE , Biermasz Nienke R , van der Klaauw Agatha A , Smit Johannes WA , Pereira Alberto M , Roelfsema Ferdinand , van der Straaten Tahar , Kroon Herman M , Kloppenburg Margreet , Guchelaar HJ , Romijn Johannes A

Objective: To evaluate the impact of the genomic deletion of exon 3 in the growth hormone receptor (d3GHR) on co-morbidities of acromegaly in a well-characterized cohort of patients with long-term remission of acromegaly.Design: Cross sectional study.Methods: The presence of the d3GHR polymorphism was assessed in 86 acromegalic patients and related to clinical outcome, i.e. anthropometric parameters, osteoarthritis, and the metabol...

ea0081oc14.4 | Oral Communications 14: Late Breaking | ECE2022

Discovery of microRNA biomarkers in circulation and bone tissue from a type-2 diabetes mellitus rat model under different anti-osteoporotic treatments

Vazquez David Carro , Emini Lejla , Rauner Martina , Hofbauer Christine , Grillari Johannes , Eastell Richard , Hofbauer Lorenz C , Hackl Matthias

Metabolic changes in Type-2 Diabetes-Mellitus (T2DM) make patients more prone to develop osteoporosis and delayed bone healing. We hypothesize that microRNAs could be involved in the underlying mechanism and used as biomarkers in this context. To test this hypothesis, we analyzed microRNAs in samples from Zucker Diabetic Fatty (ZDF) rats, a T2DM model with reduced bone healing and bone mass. 11-week-old male ZDF and wildtype rats with a femur subcritical defect were treated wi...