Endocrine Abstracts

Background: Pituitary hyperplasia is a relatively common yet frequently overlooked condition which can occur in both physiological and pathological states. Pregnancy is one of the most common conditions associated with physiological pituitary enlargement.Case Presentation: 22-year-old normally fit and well lady presented to AMU (acute medicine unit) with a week history of headache and 10-month history of amenorrhoea following cessation of combined contra...

Background: Familial hypocalciuric hypercalcaemia (FHH) is a rare benign autosomal dominant condition which causes life-long mild to moderate hypercalcaemia. It is usually underdiagnosed due to lack of symptoms in majority of patients and low rate of screening even among endocrinologists. Recent NHS England National Genomic Directory testing criteria for FHH recommend testing patients presenting with hypercalcaemia and calcium creatinine clearance ratio (CCCR)...

Introduction: Hypophysitis is the inflammation of the pituitary gland, characterised by hypopituitarism and pituitary enlargement. It can occur as primary (commonly lymphocytic, granulomatous or xanthomatous) or secondary to systemic disease, immunotherapy or sella-based pathologies.Case Presentation: A 30-year-old female was admitted to hospital with headache, fatigue, low mood and blurred vision, 3 months after having ...

Background: There is clear evidence that achieving optimal glycaemic control in type 1diabetes reduces the complications of diabetes. Increased technology use is associated with lower HbA1c. NICE target HbA1c is 48 mmol/mmol.Objective: Are there differences in HbA1c between patients with Type 1 diabetes using continuous glucose monitoring sensor (CGM) or hybrid closed loops in real world setting in paediatric patients at...

Introduction: Single-electrolyte derangement is a common biochemical finding. Multiple-electrolytes derangement is less common and require multiple and simultaneous corrective therapies. We present a patient who had multiple admissions with multiple-electrolytes derangement, which after further evaluation required a single therapeutic intervention.Case: A 26-year-old lady had eight admissions over three years with abdominal pain and vomiting. During each...

Introduction: Single-electrolyte derangement is a common biochemical finding. Multiple-electrolytes derangement is less common and require multiple and simultaneous corrective therapies. We present a patient who had multiple admissions with multiple-electrolytes derangement, which after further evaluation required a single therapeutic intervention.Case: A 26-year-old lady had eight admissions over three years with abdominal pain and vomiting. During each...

Introduction: Acromegaly is a rare metabolic condition in adults caused by over secretion of growth hormone from the pituitary gland. The characteristic skeletal and organ overgrowth and dental mal-occlusion issues are so insidious that they go unnoticed by the patient and family. The dentist may be the first healthcare provider to see these patients, thereby proving instrumental in early diagnosis. We report two cases of acromegaly: one case identified by a dentist and anothe...

Background: The prevalence of iodine-based contrast media-induced (ICM-induced) thyroid dysfunction varies (1-15%). Contrast-induced hyperthyroidism is predominantly found in iodine-deficient regions and in patients with underlying nodular goitre or latent Graves’ disease. Beta-blockers are first-line therapy, but anti-thyroid medication are used for severe symptomatic cases.Case Report: A 79-year-old man presented with a 4-day history of bilious vo...

Management of type-2 diabetes (T2D) should be individualised given recent increase in treatment options. There is a spectrum of phenotype of T2D from thinner patients who may be more insulin deficient to those who are overweight/obese and insulin resistant. We hypothesized that, if we are personalising treatment, thinner patients would be more likely to be treated with insulin secretagogues. To compare the management between these phenotypes, we reviewed 1007 patients with T2D...

Background: Antithyroid drugs (ATDs) are preferred as a first-line treatment for Graves’ disease (GD). However, around 50–60% of patients relapse following treatment withdrawal. Radioactive iodine (RAI) or thyroidectomy is recommended for these patients, however, repeat ATD therapy is a further option, dependent upon patient choice. The long-term efficacy of ATD in relapsed GD has not been robustly established.Methods: We conducted a retrospect...