Searchable abstracts of presentations at key conferences in endocrinology

ea0022p168 | Cardiovascular endocrinology and lipid metabolism | ECE2010

Sexual dimorphism of cardiovascular ischemia susceptibility is mediated by heme-oxigenase synthase

Posa Aniko , Szablics Peter , Vari Beata , Szalai Zita , Kiss Gyongyi Karcsune , Varga Csaba , Laszlo Ferenc

In the reproductive age, it is well-known that males are more sensitive to cardiovascular ischemic disease than females. In our study, we investigated the role of heme-oxigenase synthase (HO), which produce endogenous vascular protective carbon monoxide, in the development of sexual dimorphism in rats. We found that HO synthase enzyme activity, and the expression its HO-1 and HO-2 isoenzyme were increased in female rat aorta and left heart ventricle compared to males. Moreover...

ea0014p208 | (1) | ECE2007

Bone mineral density and body composition in pubescent obese children endangered by metabolic syndrome

Tobisch Borbala , Kozma Andrea , Nagy-Szakall Zsuzsanna , Peter Ferenc , Blatniczky Laszlo

Aims: The prevalence of type 2 diabetes due to insulin resistance is increasing in puberty. Authors have investigated whether body weight excess arises only from increased fat content of the body. Different anthropometrical data were also analysed if they are able to predict degree of insulin resistance.Materials and methods: 108 obese children (50 female, 58 male, Tanner st-s1-5, mean age 12.06 years, mean BMI: 30.97 kg/m2) with positive fami...

ea0014p354 | (1) | ECE2007

Endothelial function and hemostasis factors in hypothyroidism and subclinical hyperthyroidism

Gazdag Annamaria , Nagy V Endre , Varga Emma , Samson Laszlo , Erdei Annamaria , Jenei Zoltan

Long-term follow-up of differentiated thyroid cancer (DTC) patients requires yearly measurements of serum thyroglobulin (Tg) levels is endogenous (4 weeks off-thyroxin) or exogenous (human recombinant TSH injection) high TSH state. Subclinical hyperthyroidism is maintained in the patients throughout the rest of the year. We examined the endothelial function, hemostasis factors and metabolic parameters in short-term iatrogenic hypothyroidism (HO) and in subclinical hyperthyroid...

ea0014p358 | (1) | ECE2007

Water purification technology reduces iodine content of drinking water and contributes to iodine deficiency

Samson Laszlo , Czegeny Ildiko , Nagy Endre V , Mezosi Emese , Erdei Annamaria

Drinking water is the major natural source of iodine in many European countries. In the present study, we examined possible sites of iodine loss during the usual water purification process. Water samples from 6 sites during the technological process were taken and analyzed for iodine content. Under laboratory circumstances, prepared iodine in water solution has been used as a model to test the effect of the presence of chlorine. Samples from the purification sites revealed tha...

ea0014p472 | (1) | ECE2007

Relapse of hyperthyroidism in Graves’ disease after long-term drug treatment

Mezosi Emese , Nemes Orsolya , Bodis Beata , Nagy Zsuzsanna , Ruzsa Beata , Rucz Karoly , Bajnok Laszlo

The optimal treatment of hyperthyroidism in Graves’ disease is still an unresolved question. Hyperthyroidism recurs in 50% of patients after discontinuation of antithyroid therapy. In this retrospective study, Graves’ patients investigated in the endocrine unit of Pecs University between December 2004 and October 2006 were enrolled (68 women, 22 men, age 47 (15–79) years). Antithyroid drug therapy was applied for a minimum of one year and the treatment was withd...

ea0099ep1317 | Late Breaking | ECE2024

Concomitant multiple myeloma in a patient with primary hyperparathyroidism

Somogyi Anna , Berta Eszter , Lengyel Inez , Varoczy Laszlo , Nagy Endre , Bodor Miklos

Introduction: Primary hyperparathyroidism (PHPT) is one of the most common causes of non-neoplastic hypercalcemia with characteristically increased or inappropriately normal plasma parathyroid hormone (PTH) levels. Hypercalcemia is also a significant feature of patients with multiple myeloma (MM), and a pathogenetic link is presumed between the two diseases, strengthened by preclinical data. Only limited number of case reports of concomitant PHPT and MM are available in the li...

ea0063p444 | Adrenal and Neuroendocrine Tumours 2 | ECE2019

The Arg244His missense mutation in SDHB-1 leads to altered metabolism in Caenorhabditis elegans: a new disease model

Saskoi Eva , Hujber Zoltan , Liko Istvan , Meszaros Katalin , Sarkadi Balazs , Matyasi Barbara , Kovacs Attila L , Patthy Laszlo , Nyiro Gabor , Svab Gergely , Tretter Laszlo , Mehta Anil , Sebestyen Anna , Patocs Attila , Takacs-Vellai Krisztina

The succinate dehydrogenase (SDH) enzyme complex consisting of four subunits (SDHA, SDHB, SDHC and SDHD) has a dual function in the process of mitochondrial energy generation. It converts succinate to fumarate as part of the TCA cycle and also transfers electrons to ubiquinone as part of the electron transport chain. Mutation in any subunit of the enzyme complex increases the risk for the development of neuroendocrine tumors including paraganglioma (PGL) and pheochromocytoma (...

ea0081ep961 | Thyroid | ECE2022

Use of thyroid hormone in hypothyroid and euthyroid patients. the THESIS questionnaire survey in spain

Carlos Galofre Juan , Attanasio Roberto , Hegedus Laszlo , Nagy Endre V. , Negro Roberto , Papini Enrico , Perros Petros , Diez Juan Jose

Background: Hypothyroidism is one of the most frequent conditions in endocrinology. Despite of that fact, indications for treatment differ among specialists in Spain.Aims: To identify attitudes of Spanish endocrinologists in the use of levothyroxine (LT4) therapy and the management of hypothyroidism.Methods: The members of the Sociedad Española de Endocrinología y Nutrición (Spanish Society of Endocrinology ...

ea0063gp73 | Thyroid Autoimmune Disorders | ECE2019

Clinical experiences in autoimmune polyglandular diseases

Pham-Dobor Greta , Bajnok Laszlo , Bodis Beata , Gergics Marin , Nemes Orsolya , Rucz Karoly , Mezősi Emese

Introduction: The autoimmune polyglandular syndrome is a complex, heterogeneous disease in which autoimmune diseases of endocrine and non-endocrine organs can occur. There are 4 subgroups: the early-onset APS I develops due to the mutation of the gene AIRE and characterized by the presence of Addison’s disease (AD), mucocutan candidiasis and hypoparathyroidism; the APS II is defined by the appearance of AD and autoimmune thyroid diseases (AITDs) and/or diabetes mellitus; ...

ea0063gp169 | Obesity (1) | ECE2019

The role of copeptin and cortisol in critically ill patients

Gergics Marin , Pham-Dobor Greta , Tarjanyi Zita , Montsko Gergely , Kőszegi Tamas , Mezősi Emese , Bajnok Laszlo

Introduction: Both cortisol and vasopressin are stress hormones. Earlier, our group demonstrated that serum concentrations of free cortisol at admissions to the Intensive Care Unit (ICU) were independent predictors of survival in critically ill patients. Other investigators have demonstrated that serum copeptin, a surrogate marker of vasopressin may also be a predictive factor in this patient population. The aim of our present study was to compare the prognostic roles of serum...