Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep164 | Calcium and Vitamin D metabolism | ECE2016

4D-CT parathyroid increases the likelihood of localising parathyroid adenoma in patients with primary hyperparathyroidism and indeterminate Tc99m-Sestamibi+I-123 subtraction scan

Lee Brian , Pandit Manish , Basu Ansu

Introduction: Tc99m-Sestamibi+I-123 subtraction using planar and SPECT-CT is commonly used to investigate PHPT. Our centre previously published sensitivity and specificity of 92 and 86% respectively for Tc99m-Sestamibi+I-123 subtraction. Five false-negative studies required neck exploratory surgery. One false-positive study incorrectly localised a PA which was not found in surgery (n=67). In recent years 4D-CT parathyroid has emerged as a useful technique to detect an...

ea0041ep363 | Clinical case reports - Thyroid/Others | ECE2016

Ovarian Leydig cell hyperplasia – an unusual cause of hyperandrogenism in a post-menopausal woman with a possible familial link

Ahmad Sajjad , Khalily Naveed , Lee Stuart

A 60-year-old lady was referred with male pattern hair loss and facial hirsutism of 5–7 years duration. She was otherwise well and had two children in their 30s. She was not taking any medication and reported a normal menstrual cycle prior to menopause at the age of 50.Her androgen profile showed a high testosterone level of 6.1 nmol/l (range <2.5), androstenedione 3.8 nmol/l (0.7–3.8), DHEAS 5.7 μm/l (0.80–4.9), SHBG 33 nmol/l, F...

ea0041ep686 | Female Reproduction | ECE2016

Cigarette smoke exposure disturbed maturation of ovarian follicle and induced abnormal growth of uterus inner wall of female rats

Lee Hae-Miru , Choi Kyung-Chul

Cigarette smoke (CS) is well known to be very harmful to human body functions such as fertility, reproduction, and development. To elucidate the effect of CS on women’s fertility more definitely, we examined the histophaological characteristics of the uterus and ovary samples received from Korean Conformity Laboratories (KCL), which were obtained from the female rats exposed to the different amounts (low, medium, and high concentrations) of smoke of the standard cigarette...

ea0041ep956 | Steroid metabolism + action | ECE2016

An estrogen receptor signaling pathway is involved in 3,3′-diindolylmethane-induced inhibition of cell migration of MCF-7 breast cancer caused by triclosan via the regulation of epithelial- mesenchymal transition

Lee Geum-A , Choi Kyung-Chul , Hwang Kyung-A

Triclosan (TCS) is an endocrine-disrupting chemical and has a potential to increase progression of hormone responsive cancers as does 17β-estradiol (E2). 3,3′-diindolylmethane (DIM), a phytoestrogen, has been known to have anticancer activity. In this study, we examined the anti-proliferative and anti-epithelial-mesenchymal transition (EMT) effects of DIM on TCS or E2-induced EMT of MCF-7 breast cancer cells, which express estrogen receptors (E...

ea0041ep960 | Steroid metabolism + action | ECE2016

17β-estradiol or triclosan-induced epithelial-mesenchymal transition and migration of MCF-7 breast cancer cells were reversed by kaempferol, a phytoestrogen

Lee Geum-A , Hwang Kyung-A , Choi Kyung-Chul

As a phytoestrogen, kaempferol plays a chemopreventive role inhibiting cancer formation and progression. In this study, chemopreventive activity of kaempferol was examined by measuring its effect on growth, epithelial-mesenchymal transition (EMT), and migration of MCF-7 breast cancer cells increased by 17β-estradiol (E2, a positive control) or triclosan (TCS), an endocrine-disrupting chemical (EDC). As an EDC, TCS is known to interfere estrogen receptor (ER) dependent pat...

ea0038p83 | Clinical practice/governance and case reports | SFEBES2015

Artifactual hypoglycaemia: lesson from a patient with unreliable finger-prick glucose due to absent finger tips

Ang An Shing , Lee Daphne , Baskar Varadarajan

Pseudohypoglycemia has been reported in patients with Raynaud’s phenomenon, peripheral vascular disease and shock and may result from increased glucose extraction by the tissues because of low capillary flow and increased glucose transit time. We present a frail and comorbid 76-year-old lady with a long standing history of Rheumatoid arthritis/systemic sclerosis/systemic lupus erythematosis overlap syndrome complicated by Raynaud’s phenomenon. She was on long-term st...

ea0038p175 | Neoplasia, cancer and late effects | SFEBES2015

Confusion in a patient with carcinoid syndrome

Aarella Vikram , Dix Hannah , Lee Stuart

A 64 year old lady was admitted with a 2 day history of feeling generally unwell. Her relatives also reported new onset confusion over these 2 days. Her bloods showed raised inflammatory markers (CRP 110.3 mg/l, WCC 18.2×109/l) hypoalbuminemia (17 g/l), bilirubinemia (55 μmol/l) and a raised alkaline phosphatase (917 IU/l). She had recently been diagnosed with carcinoid syndrome; primary tumour situated in the terminal ileum with liver metastasis and had b...

ea0058p047 | Diabetes | BSPED2018

Audit on the recognition and response to hypertension in young people with type 1 diabetes mellitus

Posner Ewa , Lee Rachel , Uttley Elizabeth

Background: Raised blood pressure (BP) in adolescents with type 1 Diabetes Mellitus (T1DM) has been associated with adverse cardiovascular outcomes independently of raised HbA1c. It is therefore of critical importance that these patients are identified early and appropriate treatment instigated. Of concerns, studies have recognised suboptimal management of hypertension in most of these young people, allowing them to succumb to complications of diabetes with hypertension in the...

ea0034p251 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2014

Metformin and acute kidney injury: is it the culprit?

Lee Phey Shen , Mackay Jonathan Donald

Three people (two males), with mean age (range) 65 (49–75) years, presented as emergencies with acute renal failure (AKI). They had type 2 diabetes mellitus, with mean duration 7 (2–12) years. All three were taking anti-hypertensive therapy: two were on ramipril and one on losartan and indapamide. All three were taking metformin with mean daily dose 2.6 (1.7–3.0) g. All three patients had mild renal impairment (CKD stage 3), but renal function was stable 2–...

ea0031p381 | Thyroid | SFEBES2013

Bilateral thyroid cysts: an important association not to forget?

Wong Mo Lee , Skene Anthony , Richardson Tristan

A 64-year-old man was referred with an incidental finding of multiple bilateral thyroid cysts following CT scanning for abdominal pain. He had originally presented with an acute episode of left upper quadrant pain. CT scan of the abdomen demonstrated multiple lesions in the liver compatible with simple cysts. There were also multiple bilateral renal cysts, of which the largest was 10 cm. A small amount of retroperitoneal fluid was seen, probably as a result of a ruptured cyst....