Endocrine Abstracts

Introduction: Pheochromocytomas are rare, mostly benign catecholamine-producing neuroendocrine tumors. Clinical manifestations are heterogenous, including persistent or paroxysmal hypertension, sweating, palpitation and headaches known as Menard triad. Diagnostic approach is based on demonstration of catecholamine excess and tumor localization. Our study aimed to describe clinico-biological and radiological features of pheochromocytomas.Methods: We condu...

Introduction: Excessive production of growth hormone (GH) in acromegaly is most commonly caused by a somatotroph pituitary adenoma. The therapeutic arsenal is based on selective transsphenoidal adenomectomy (STA) as a first-line treatment. The aim of our study was to determine predictive factors of postoperative biochemical remission in acromegalic patients.Methods: We conducted a retrospective study including 18 acromegalic patients followed-up in the e...

Introduction: The management of acromegaly is commonly based on selective transsphenoidal adenomectomy (STA) as a first-line treatment, and other therapeutic options including somatostatin analogues (SA), dopamine agonists (DA) and radiotherapy as second-line treatment or in case of operative contraindications. The aim of our study was to assess the remission rate and to determine the predictive factors for long-term remission in acromegalic patients.Met...

Introduction: Somatotropin macroadenomas are associated with a considerable risk of ophthalmological impairment. The aim of our study was to determine the prevalence of ophthalmological complications and their associated factors in patients with acromegaly.Methods: We conducted a retrospective study including 28 patients with somatotropin adenomas and followed in the endocrinology department of Charles Nicolle Hospital. Clinical, biochemical and imaging ...

Introduction: Acromegaly results from an autonomous hypersecretion of growth hormone (GH) typically by a pituitary adenoma, commonly revealed by a dysmorphic syndrome. The aim of our study was to describe clinico-biological and radiological features of acromegaly.Methods: We conducted a retrospective study including 28 patients with acromegaly followed in the endocrinology department of Charles Nicolle Hospital. Clinical, biochemical, ophthalmological an...

Background: The primary empty sella (PES) is radiologically defined as partial when less than 50% of the sella is filled with cerebrospinal fluid (CSF) and pituitary gland thickness is ≥3 mm or total when more than 50% of the sella is filled with CSF and the gland thickness is ≤2 mm in diameter.The aim of our study was to evaluate clinical and radiological aspects of PES.Methods: We retrospectively evaluated clinical features and radiological...

Background: The term primary empty sella (PES) makes reference to the herniation of the subarachnoid space within the sella turcica in patients with no history of pituitary tumor,surgery or radiotherapy. The aim of our study was to evaluate hormonal abnormalities associated with PES.Methods: Thirty-six patients with PES were retrospectively analysed over a 24-year period [1992-2016].Patients were evaluated for pituitary function with basal hormone levels...

IntroductionVon Hippel-Lindau (VHL) syndrome is an autosomal dominant disease resulting in a susceptibility to develop central nervous system and retinal hemangioblastomas, endolymphatic sac tumors, renal clear cell carcinoma and pheochromocytoma. Pheochromocytoma occurs usually at a younger age and tends to be bilateral in VHL syndrome. Herein, we describe a case of VHL syndrome with cerebellar hemangioblastoma, bilateral pheochromocytoma and kidney tum...

IntroductionThe adrenocortical carcinoma(ACC) is a rare malignant tumor arising from the adrenal cortex, it is usually associated to abnormal hormone secretion, but sometimes it is nonfunctioning, leading to a delayed diagnosis with a locally advanced and/or a metastatic disease. ObservationWe report the case of a 42 year-old woman with no medical history who consulted for chronic epigastralgia. On physical e...

IntroductionInsulinoma is a rare neuroendocrine tumor with an incidence of 1 to 4 per million person-years. It is the most frequent endocrine tumor of the pancreas and is revealed by a spontaneous hypoglycemia in the absence of insulin or any antidiabetic medication.Only few cases of confirmed insulinoma with pregnancy have been described in the literature. We describe a case of insulinoma discovered early in pregnancy.Case report<...