Searchable abstracts of presentations at key conferences in endocrinology

ea0075t08 | Thyroid | EYES2021

Antibody Interference in Thyroid Assays: a case report

Mura Chiara , Menotti Sara , Zelano Lorenzo , Novizio Roberto , Rossi Laura , Carrozza Cinzia , Locantore Pietro , Maria Corsello Salvatore

Background: Endogenous and exogenous factors may cause biochemical interferences with thyroid function immunoassays. Interference can be caused by many mechanisms including heterophilic antibodies, drugs and rheumatoid factors. Moreover, assay-specific interference has been described, such as antithyroid hormone antibodies resulting in falsely elevated or lowered concentrations depending on the assay.Case Presentation: We describe a case of a 38-years ol...

ea0081p203 | Thyroid | ECE2022

Transoral endoscopic thyroidectomy (TOETVA) in thyroid cancer, our view as endocrinologists

Mallea-Gil Susana , Sanchez Yamila , Coca Bibiana , de los Angeles Sosa Maria , Palazzo Adriana , Rossi Javier , Marta Aparicio Maria , Sankowicz Silvina , Estevez Samanta , Ballarino Carolina

Recent progress in surgical technology has resulted in new techniques as transoral endoscopic thyroidectomy (TOETVA) that is an option for patients’ cosmetic requests. We evaluated patients with thyroid cancer who underwent thyroidectomy by TOETVA approach and their follow-up. Retrospective study, 5 patients were included, Bethesda classification in FNAC resulted: 2 patients with VI category (CAT), 2: V CAT and 1: III CAT. All patients were operated by TOETVA between 2020...

ea0041gp136 | Obesity | ECE2016

A novel human fetal brown stem cell functional model to study brown adipogenesis

Franco Alessandra Di , Guasti Daniele , Squecco Roberta , Mazzanti Benedetta , Rossi Francesca , Idrizaj Eglantina , Gallego-Escuredo Jose , Villarroya Francesc , Bani Daniele , Forti Gianni , Vannelli Gabriella Barbara , Luconi Michaela

The potential therapeutic applications of targeting brown adipose tissue open new clinical avenues in fighting against metabolic pathologies. However, due to the limited brown depots in adult humans, dramatically reduced after birth, solid cell models to study human brown adipogenesis and its pathophysiological regulation are urgently needed.In our study, we characterized a novel human model of brown adipose stem cells, hfB-ASC, derived from fetal inters...

ea0037gp.24.02 | Thyroid–genetics | ECE2015

In papillary thyroid cancer TERT promoter mutations have a worst impact on outcome than BRAF mutations

Muzza Marina , Colombo Carla , Proverbio Maria Carla , Rossi Stefania , Tosi Delfina , Perrino Michela , De Leo Simone , Cirello Valentina , Bulfamante Gaetano , Vicentini Leonardo , Fugazzola Laura

TERT promoter mutations (chr5: 1 295 228C>T e chr5: 1 295 250C>T) were recently described in thyroid tumors, with a prevalence ranging 8–25% in papillary thyroid cancer (PTC). We and others reported that these mutations strongly associate with a poor outcome in differentiated thyroid cancers. Aim of the present study was to further investigate the prognostic role of both TERT promoter (TERTMUT) and BRAF<...

ea0037ep858 | Thyroid cancer | ECE2015

The evaluation of sex hormone receptors in papillary thyroid cancer as an additional tool in the post-operative risk stratification and in the pre-gravidic counselling of women with persistent disease

Fugazzola Laura , De Leo Simone , Perrino Michela , Rossi Stefania , Tosi Delfina , Cirello Valentina , Colombo Carla , Bulfamante Gaetano , Vicentini Leonardo , Vannucchi Guia

Thyroid cancer is highly prevalent in women aged 15–44 years, suggesting that in females the fertile age could be regarded as a risk factor. Consistently, in the last decades epidemiological and experimental findings indicated a possible role of oestrogens in the development and progression of differentiated thyroid tumours. We studied the expression of oestrogen receptor α (ER α) and Progesteron receptor (PR) in 182 female and male patients with papillary thyro...

ea0037ep868 | Thyroid cancer | ECE2015

Role of miR-26a in follicular thyroid carcinoma

Gentilin Erica , Ortolan Elisa , Gagliano Teresa , Pasquale Carmelina Di , Falletta Simona , Rossi Roberta , Benfini Katiuscia , Tagliati Federico , Uberti Ettore Degli , Zatelli Maria Chiara

Follicular thyroid carcinoma (FTC) is the second most common thyroid malignant epithelial tumor. It is clinically asymptomatic, usually represented by a single nodule, less often multiple, with origin from thyroid follicular epithelial cells. Despite its well-differentiated characteristics, FTC may develop distant metastases through hematogenous dissemination. The molecular alterations involved in the pathogenesis of follicular neoplasia are not completely known. Recent studie...

ea0029p1594 | Thyroid (non-cancer) | ICEECE2012

Enhanced expression of the B cell activation factor (BAFF) and baff-receptor (BAFF-R) in the thyroid and in the orbital adipose tissue from patients with graves’ disease (GD) and associated orbitopathy (GO)

Campi I. , Vannucchi G. , Covelli D. , Rossi S. , Doi P. , Curro N. , Pignataro L. , Guastella C. , Beck-Peccoz P. , Salvi M.

BAFF, a member of the TNF family, promotes autoantibody production by increasing B cell survival and proliferation. We have previously shown that serum BAFF concentrations are increased in GD patients. In the present work, we studied the expression of BAFF and BAFF-R, by immunohistochemistry (IHC) on paraffin embedded sections of: 1. orbital adipose tissue from 22 patients (5 men, 17 women) with GO (3 of them with active GO) associated with GD or Hashimoto thyroiditis in 19 an...

ea0029p1822 | Thyroid cancer | ICEECE2012

Prevalence of differentiated thyroid cancer is relevant in patiens with familial adenomatous polyposis: a case-control prospective study

Diazzi C. , Benatti P. , Zirilli L. , Gnarini V. , Madeo B. , Romano S. , Rossi G. , Carani C. , Ponz de Leon M. , Roncucci L. , Rochira V.

Introduction: Familial adenomatous polyposis (FAP) is a dominantly inherited disease characterized by colorectal adenomas, extracolonic gastrointestinal manifestations and extraintestinal diseases. Among them, differentiated thyroid cancer (DTC) is considered very frequent with an approximately risk 160 times higher than in general population, and with a prevalence of the cribriform-morular variant. As this esteem comes from scattered data, we evaluated in a prospective contro...

ea0026p289 | Pituitary | ECE2011

ACTH-secreting pituitary adenomas express higher SSTR5 than SSTR2 protein levels by immunohistochenistry using new monoclonal antibodies against SST-binding domains

Rossi V , Bellastella G , Staibano S , Ilardi G , Del Basso De Caro M L , Cavallo L , Cappabianca P , Abbondanza C , Colao A , Bellastella A , Sinisi A A

Pasireotide (SOM230), a somatostatin (SST) analogue targeting multiple SST receptors, is effective in reducing urinary free cortisol in patients with Cushing disease (CD), due to inoperable or recurrent ACTH secreting pituitary adenomas. The efficacy of SOM230 seems to be dependent on the presence of appropriate SSTRs, mainly SSTR2 and 5, on the membrane of tumor cells. Polyclonal antibodies available up to now recognizing cellular intracellular sites of receptors and their re...

ea0026p624 | Clinical case reports | ECE2011

17β-hydroxysteroid dehydrogenase type 3 deficiency: a new case of a rare disease with an uncommon gene mutation

Galdiero M , Vitale P , Cariati F , Grasso L F S , Cozzolino A , Simeoli C , Afeltra L , Piscopo C , Rossi R , Melis D , Alviggi C , Lombardi G , Colao A , Pivonello R

Deficiency of 17β-hydroxysteroid dehydrogenase type 3 (17βHSD3), an enzyme converting androstenedione (A) to testosterone (T) in the Leydig cells of the testis, is a rare cause of autosomal recessive 46,XY disorders of sexual development (DSD). A 18-year-old phenotypically female patient presented with primary amenorrhea. She had deep voice, macrocephaly, broad forehead, enlarged nasal tip, macrostomia, facial acne, gynecomastia, left-convex dorsal scoliosis, hypopla...