Endocrine Abstracts

Aim: Patients with malignant neuroendocrine tumors (mNETs) present frequently metastatic disease at diagnosis or during their follow-up. Hepatic transplant (HT) and radionuclide treatment have proved to be successful treatments. The aim of this report is to study the progression of the disease in patients with metastasic mNETs and HT.Patients and methods: Descriptive and retrospective study of patients diagnosed of metastasic mNETs and submitted to HT du...

Background: Thyroid function, insulin resistance, serum lipid, C-reactive protein (CRP) and homocysteine are associated with an increased cardiovascular risk in patients with autoimmune thyroiditis (AIT).Objective: To evaluate the interrelations between thyroid function, insulin resistance, serum lipid concentrations, CRP and homocysteine in patients with AIT and subclinical hypothyroidism.Subjects and methods: We recorded thyroid ...

Background: Autoimmune thyroiditis (AIT) is associated with increased risk of cardiovascular disease.Objective: To evaluate the interrelationships between insulin resistance (IR) and other cardiovascular risk factors, such as high sensitivity CRP (C reactive protein) and homocysteine in patients with AIT.Patients and methods: We analysed thyroid function, anti-thyroid antibodies, BMI, indices of IR, such as HOMA-IR, HISI (Hepatic I...

Background: Thyroid dysfunction and lipid profile are associated with cardiovascular disease in patients with autoimmune thyroiditis (AIT).Objective: To evaluate the association between thyroid function, lipid concentrations, C-reactive protein (CRP) and homocysteine in patients with AIT.Patients and methods: We assessed thyroid function tests, BMI, total cholesterol (TC), HDL-cholesterol, LDL-cholesterol, triglycerides (TG), apoli...

Aims: To examine whether treated autoimmune thyroiditis (AIT) and Graves’ disease (GD) are associated with increased cardiovascular risk factors.Patients and methods: We analysed the levels of total cholesterol (TC), HDL, LDL, triglycerides (TG), ApoB, ApoA1, Lp[a], homocysteine, CRP, folic acid and vitamin B12 in 50 patients with GD and in 130 patients with AIT, after normalization of thyroid function. Patients with GD were treated with propylthiou...

Objective: The aim of this study was to examine the hypothesis that thyroid function, in euthyroid subjects with autoimmune thyroiditis (AIT), is associated with insulin resistance, serum lipid concentrations, and other cardiovascular (CV) risk factors. Subjects and Methods: We recorded thyroid function tests, BMI, insulin resistance markers comprising the Homeostasis Model Assessment for insulin resistance (HOMA-IR), the Quantitative Insulin Sensitivity Check Index (QUICKI), ...

Background/aim: Vitamin D receptor (VDR) expression has been shown to be upregulated in several tumors and is thought to represent an important endogenous response to tumor progression. Therefore, in order to evaluate the role of VDR-gene and of the 25(OH)-Vitamin D3 in thyroid cancer we analysed four polymorphisms in patients with thyroid cancer and healthy controls.Patients and methods: Patients (n=136; 84 females and 52 males) with d...

Craniofacial proportions of girls with TS, compared to normal children, show reduced size of the craniofacial complex, retrognathic profile and tendency towards advanced dental age. Growth hormone (GH) treatment in TS positively affects stature, but its effects on craniofacial growth and dental development are largely unknown. The aim of this study was to analyze and to correlate the craniofacial morphology, chronological, dental and bone ages of TS patients receiving GH or no...

Growth is a complex process, influenced to a large extent by GH. Children with GH deficiency (GHD) have typical somatic features, including short stature and a reduction of the craniofacial structures. Dental age (DA) is normally delayed in relation to chronological age (CA). The effect of GH replacement on craniofacial growth is still poorly understood. We studied the craniofacial development and dental maturation in 17 patients (4F, 13M) with GHD of different etiologies. The...

Introduction: Post-stroke hyperglycemia affects two-thirds of the patients during acute ischaemic stroke and it is associated with poorer outcomes. The aim of this study was to analyze the differences between the diabetic and non- diabetic patients that underwent an acute stroke.Methods: Retrospective descriptive study of patients admitted to the Acute Stroke Unit from January to June 2017, including blood parameters, glycemic treatment and 3 months outc...