Endocrine Abstracts

Section 1: Case history: A 46 year old man with Becker Muscular Dystrophy (BMD), was admitted with palpitations and shortness of breath. He had a past medial history of severe left ventricular dysfunction (LVSD) and cardiac arrhythmias, including atrial fibrillation (AF) treated with amiodarone, and an implantable cardiac defibrillator (ICD) for non-sustained ventricular tachycardia (VT). He had been treated with 3 months of prednisolone for suspected type 2 amiodarone induced...

Background: Radioiodine treatment (RIT) for benign functioning thyroid disease is an effective treatment for patients with hyperthyroidism. The safety, preparation, administration and follow-up of treatment demands time and organisation. The planning of this elective treatment is affected by the patient’s availability which makes adequate and timely treatment of the subsequent hypothyroidism challenging. A quality improvement project was therefore set up to mitigate this....

Background: Radioiodine treatment (RIT) for benign functioning thyroid disease is an effective treatment for patients with hyperthyroidism. The safety, preparation, administration and follow-up of treatment demands time and organisation. The planning of this elective treatment is affected by the patient’s availability which makes adequate and timely treatment of the subsequent hypothyroidism challenging. A quality improvement project was therefore set up to mitigate this....

Background: Congenital Hyperinsulinism (CH) or, as previously named, Hyperinsulinemic Hypoglycemia (HH), constitutes a major cause of persistent and recurrent hypoglycemia, especially in the neonatal period, showing notable phenotypical heterogeneity among affected subjects. Mutations in genes implicated in insulin release, represent the majority of the cases of CH. Activating mutations of the Glucokinase gene (GCK) are responsible for mild forms of hypoglycemia usual...

DPP4 inhibitors are special class of drugs that not only improve metabolism in a glucose dependant manner, but also suppress the glucagon axis. Due to its glucose dependant insulinotropic action, vildagliptin is thought to be relatively safe for people who are at risk of developing low glucose episodes. We studied the glucose lowering potential and hypoglycemic effects of vildagliptin among elderly diabetics who were uncontrolled with at least 2 oral antidiabetic medications. ...

Context: Fluid restriction (FR) is recommended as first line therapy for SIAD by both the European1 and the American guidelines2 for management of SIAD. Not all patients respond to FR however, and the American guidelines have identified clinical predictors of failure to respond to FR. These include 1.Urine osmolality (UOsm) >500 mOsm/Kg 2. Furst formula (ratio UNa+UK/pNa) > 1, and 3. 24 hour-urine volume<1500 mlObjective...

Objective: Brachial-ankle pulse wave velocity (baPWV) was used as a noninvasive marker of arterial stiffness. The aim of this study was to assess the association between arterial stiffness and cause specific mortality in patients with type 2 diabetes mellitus (T2DM).Methods: This multicenter prospective observational study analyzed 2,320 patients with T2DM. The patients were divided into two groups according to baPWV (cutoff baPWV of 1,750 cm/s). Causes ...