Searchable abstracts of presentations at key conferences in endocrinology

ea0022p147 | Cardiovascular endocrinology and lipid metabolism | ECE2010

Gender variations of serum Paraoxonase-1 activities in healthy young men and women: association with carotid intimae media thickness

Yavuz Dilek Gogas , Tarcin Ozlem , Gun Palmet , Sirikci Onder , Akalin Sema

Aim: Paraoxonase-1 (PON-1), an HDL-associated enzyme has been shown to possess antioxidant properties that protect against atherosclerosis. The aim of this study is to evaluate serum paraoxanase activities, lipid profiles and carotid intimae media thickness (CIMT) as an early marker of atherosclerosis in healthy man and women.Method: Four hundred healthy volunteers (F/M: 250/150, 19–23 years) included in the study. Serum paraoxonase and arylesterase...

ea0014p406 | (1) | ECE2007

Carotid intima media thickness and bone turnover in type 2 diabetic patients

Sancak Seda , Yavuz Dilek , Toprak Ahmet , Deyneli Oguzhan , Tarcin Ozlem , Yazici Dilek , Aydin Hasan , Akalin Sema

Recent studies indicate that atherosclerotic process is associated with bone metabolism. The aim of this study was to evaluate carotid intima media thickness (CIMT) and its association with bone mineral density and bone turnover markers as well as inflammation markers in type 2 diabetic male patients.Material-method: 184 type 2 diabetic males (56±8 y) and 85 non-diabetic control subjects (52±7 y) were recruited. Bone mineral density was measure...

ea0014p415 | (1) | ECE2007

Evaluation of diastolic function and its relationship with carotis intima media thickness and endothelial function in asymtomatic hyperparathyroid patients

Yazici Dilek , Tarcin Ozlem , Ozben Beste , Toprak Ahmet , Deyneli Oguzhan , Sancak Seda , Yavuz Dilek , Akalin Sema

Symptomatic hyperparathyroid patients are under risk of increased cardiovascular mortality, associated with left ventricular hypertrophy, diastolic dysfunction and accelerated atherosclerosis. Data on asymptomatic hyperparathyroid patients are conflicting. This study aimed to determine diastolic dysfunction and its association with carotis intima media thickness (CIMT) and flow-mediated vasodilation (FMD) in a group of asymptomatic hyperparathyroid patients.<p class="abste...

ea0022p410 | Endocrine tumours &amp; neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Evaluation of respiratory function in acromegalic patient

Serap Yalin Ayse , Sancak Seda , Temizkan Sule , Gunes Mutlu , Deyneli Oguzhan , Yavuz Dilek , Karakurt Sait , Sema Akalin Nefise

Acromegaly alters elasticity, structure and function of the respiratory system and respiratory disorders constitute 25% of all deaths recorded in acromegalic patients. Respiratory mortality is three fold higher than in normal subjects. However, respiratory dysfunction in acromegaly has seldom been investigated.We aimed to evaluate the extent of pulmonary dysfunction in acromegalic patients with respiratory function tests (RFT). Sixty one acromegalic pati...

ea0014p275 | (1) | ECE2007

Effect of vitamin D replacement on endothelial function and oxidative stress in vitamin D deficient subjects

Tarcin Ozlem , Yavuz Dilek , Toprak Ahmet , Telli Ahu , Yuksel Meral , Yazici Dilek , Sancak Seda , Deyneli Oguzhan , Haklar Goncagul , Akalin Sema

Introduction: Vitamin D (Vit D) receptors have been shown in extra skeletal tissues. Vit D deficiency plays a role in the development of many malignant, chronic inflammatory, autoimmune and metabolic diseases. Our aim was to evaluate the effect of Vit D replacement therapy on insulin sensitivity, endothelial function and oxidative stress in Vit D deficient subjects.Material-method: Serum 25(OH) D levels of 74 volunteer-healthy subjects (22.7±2.7) we...

ea0014p337 | (1) | ECE2007

The relationship of epicardial fat thickness with carotid intima media thickness and endothelial function in subclinical and overt hypothyroidism

Yazici Dilek , Aydin Hasan , Özben Beste , Toprak Ahmet , Yavuz Dilek , Tarcin Ozlem , Sancak Seda , Deyneli Oguzhan , Akalin Sema

Hypothyroidism is associated with increased cardiovascular mortality. Epicardial fat thickness (EFT) has been found to be correlated with visceral fat accumulation and is thought to be a novel cardiovascular risk factor. The aim of this study was to determine EFT and its relationship with carotid intima media thickness (CIMT) and flow-mediated vasodilation (FMD) in subclinical and overt hypothyroid patients.Ten patients with overt (Group H) (42.2±15...

ea0014p396 | (1) | ECE2007

Vitamin D receptor gene polymorphisms: influence on bone metabolism in type 1 diabetic patients

Yavuz Dilek Gogas , Yazici Dilek , Yüksel Meral , Kiyici Sinem , Sert Murat , Sahin Ibrahim , Keskin Lerzan , Deyneli Oguzhan , Aydin Hasan , Tuncel Ercan , Akalin Sema

Patients with type 1diabetes mellitus are at higher risk of developing osteoporosis. Among the genetic factors related to the development of osteoporosis, a possible association between vitamin D receptor (VDR) gene polymorphism and bone mineral density (BMD) has been described in some populations.The aim of this study is to investigate the distribution of vitamin D receptor (VDR) polymorphisms and relation to bone turnover parameters and bone densitomet...

ea0014p411 | (1) | ECE2007

Vitamin D receptor gene Bsm1 and Fok1 polymorphisms and indices of bone mass and bone turnover in healty young Turkish men and women

Yavuz Dilek Gogas , Yuksel Meral , Tarcin Ozlem , Yazici Dilek , Telli Ahu , Sancak Seda , Deyneli Oguzhan , Aydin Hasan , Haklar Goncagul , Akalin Sema

Aim: Peak bone mass is a major determinant of osteoporosis risk in later life. It is under strong genetic control; In the present study, we investigated the relationship between polymorphisms in the gene encoding the vitamin D receptor (VDR) (FokI and Bsm 1) and bone mineral density (BMD), bone mineral content (BMC), and markers of bone turnover in 106 young Turkish women (19–23 yrs) and 100 man (19–23 yrs). Methods: BMD and BMC were measured by dual-energy X-ray abs...