Searchable abstracts of presentations at key conferences in endocrinology

ea0077p206 | Metabolism, Obesity and Diabetes | SFEBES2021

A quality improvement project to assess the management of diabetes in out-patient clinic as per the NICE guidelines

Ali Anyat

Purpose: The aim of diabetes management is to prevent the micro/macrovascular complications. We have designed a quality improvement project to monitor how we are doing in term of glycaemic control and overall management of diabetes in our out-patient facility and how can we improve the outcome further.Methods: Parameters checked (HbA1C, blood pressure, lipid profile, annual fundus examination, podiatry, urine for ACR). Retrospective study of 112 patients...

ea0065hdi1.3 | How do I. . .? 1 | SFEBES2019

How do I decide which patients with gynaecomastia need more detailed evaluation

Ali Sarah

Gynaecomastia is the proliferation of the male breast glandular tissue and should be distinguished from lipomastia (weight-related fat deposition, also known as pseudogynaecomastia). The development of subareolar ductular tissue and fibrosis in gynaecomastia produces a firmer consistency compared to adipose tissue, which can be differentiated on examination. Gynaecomastia is common and can affect up to two-thirds of adult men. Typically, gynaecomastia arises from an imbalance ...

ea0049s11.2 | New Roles for Nuclear Receptors | ECE2017

Crosstalk between estrogen signalling and DNA damage repair

Ali Simak

Estrogen receptors (ER) are expressed in the majority of breast cancers, are key drivers of breast cancer development and progression and hence therapies to inhibit their activities are a mainstay of treatment for breast cancer. A large proportion of patients develop resistance to these therapies, so determining the mechanisms of ER action is important for improving patient management and for identifying new therapies. In defining the mechanisms by which ER regulates gene expr...

ea0038s11.1 | Epigenetics in endocrine-related cancers (Supported by <emphasis role="italic">Endocrine-Related Cancer</emphasis>) | SFEBES2015

Oestrogen receptors and epigenetics in breast cancer aetiology and outcome

Ali Simak

Oestrogens promote breast cancer development and progression by binding to the oestrogen receptors. Oestrogen receptor-alpha (ER) is a transcription regulatory protein that is activated upon binding oestrogen and acts by controlling gene expression in breast cancer cells and is the target for endocrine therapies that inhibit its activity by competing with oestrogen for binding to ER (anti-oestrogens) or by inhibiting oestrogen biosynthesis (aromatase inhibitors). These therapi...

ea0077p127 | Thyroid | SFEBES2021

Can a person with long standing hypothyroidism develop thyrotoxicosis despite stopping thyroxine?

Khan Amjad Ali , Ali Tauni Rahat

A 65-year-old lady who was known to hypothyroidism and was treated with Levothyroxine 100microgram once daily for more than 20 years presented to the endocrine clinic with symptoms and signs of thyrotoxicosis. Apart from Levothyroxine, she was taking over-the-counter multivitamins and Vitamin D. Visual fields were full to confrontation and there was no goitre. Thyrotoxicosis was confirmed biochemically and levothyroxine was stopped. Despite being off Levothyroxine for more tha...

ea0069p46 | Poster Presentations | SFENCC2020

Diabetic neuropathic cachexia

Tanveer Quratulain , Rathore Ali

Case: 55 year old male presented with severe sharp and burning pain at anterior aspect of both legs (radiating from groin to feet), worse at night, unable to keep bed sheets lying on legs due to pain (allodynia). Patient reported weight loss of 3 stones in last 1 year including a recent 1 stone weight loss in 2 months. Patient is a type II DM for the last 3 years. He was intolerant to Metformin and is on Gliclazide 160 mg BD. Alcohol intake around 40 units per week. Initial in...

ea0065p258 | Metabolism and Obesity | SFEBES2019

Severe peri-partum hyponatraemia: is oxytocin always the culprit?

Ali Tauni Rahat

A 34-year old pregnant lady had induction of labour with prostaglandins and oxytocin infusion after her due date. She failed to progress in labour and became slightly disoriented. Urgent biochemistry revealed serum sodium of 124 mmol/l. She delivered a healthy baby by forceps but had post-partum haemorrhage of 1.5 l. Oxytocin infusion was continued along with Hartmann’s solution. She became drowsy and biochemistry revealed serum sodium of 118 mmol/l, low serum osmolality,...

ea0063p285 | Pituitary and Neuroendocrinology 1 | ECE2019

Precocious puberty in girls in Qazvin, Iran from 2006–2018

Saffari Fatemeh , Homaei Ali

Background: This is associated with important physiological and psychobiological changes for the girl, the family and society. Decreasing the age of puberty has made it difficult to adapt to early sexual activity. Therefore, the diagnosis and management of precocious puberty must be specially considered to ensure the health of future generations. The appearance of secondary sexual characteristics in girls under the age of 8 is considered as precocious puberty (_2.5SD lower tha...

ea0049gp106 | Diabetes therapy &amp; complications 2 | ECE2017

Outcomes of integrating personal continuous glucose monitors with insulin pumps in a University Diabetes Unit

Rizvi Ali , Smith Kyoka

Objective: Personal continuous glucose monitoring (pCGM) with interstitial fluid glucose sensing is rapidly becoming the standard of care for real-time, intensive insulin therapy of diabetes. We report our experience of glycemic control in patients in an academic setting using minimally invasive pCGM with continuous s.c. insulin infusion (CSII, or insulin pump) vs CSII alone.Methods: Over a two-year period, we reviewed all patients treated with insulin p...

ea0049ep874 | Endocrine tumours and neoplasia | ECE2017

Insulinoma in MEN type 1 mistaken as temporal lobe epilepsy

Mohd Ali Norhaliza

Multiple endocrine neoplasia type 1 (MEN 1) is a rare autosomal dominant disease characterized by pancreatic, parathyroid, and anterior pituitary tumours. Hypercalcaemia due to parathyroid tumours is usually the first manifestation. Pancreatic islet tumours occur less frequently, among them gastrinomas and insulinomas are the most prevalent. Insulinomas can be difficult to diagnose. It was not uncommon for patients to have been misdiagnosed with psychiatric illnesses or seizur...