Endocrine Abstracts

One of the fundamental challenges facing current biology concerns the molecular basis for stem cell formation and behaviour. Haematopoiesis is the best characterised adult stem cell system and continues to provide paradigms of broad biological relevance. The stem cell leukaemia (SCL) gene encodes a transcription factor that is essential for the normal development of haematopoietic stem cells (HSC) and all haematopoietic lineages. Appropriate transcriptional regulation is criti...

Prolactin is present in serum in a variety of forms defined by different molecular masses. Macroprolactin is the best-known variant, a high molecular mass (150–170 kD) form of prolactin usually representing a prolactin–IgG complex which reacts in immunoassays causing apparent hyperprolactinaemia. Big-prolactin is a smaller high molecular mass (50–60 kDa) form of prolactin found more commonly than macroprolactin; however, the origin and significance of big-prolac...

Thyroid Eye Disease (TED) is an autoimmune inflammatory condition of the orbit occurring in the setting of thyroid disease. Prevention of the distressing physical and psychological sequelae of TED depends on accurate quantification of disease activity to allow selection of the most appropriate treatment modality. Current practice is based on the use of a Clinical Activity Score (CAS). As an alternative approach, and with the potential benefits of reproducibility and ease of us...

AımThe aim of this study is to investigate the attitude of physicians, who are specialized in internal medicine, endocrinology, nurology and cardiology, on LDL target levels and antilipidemic treatments in Turkey.MethodsThis study outlines attitudes of physicians towards the guideline-recommended LDL target levels in diabetic dyslipidemia. An invitaiton to fill a questionnaire on demographic and professi...

Introduction: Many studies have shown that dietary protein content may play a role in weight management. Moreover, it has been found that diets high in protein (either animal or plant) significantly reduced markers of insulin resistance and hepatic necroinflammation independently of body weight change. This study aimed to examine the effect of dietary protein source on body composition and cardiometabolic risk factors in young adults with obesity during anti-inflammatory weigh...

Introduction: Hypophosphatasia (HPP) is a very rare systemic musculoskeletal disease characterised by low tissue non-specific alkaline phosphatase (ALP). The prevalence of HPP and its associated morbidity in an adult setting is unclear.Methods: A search for serum ALP results less than 36 IU/l within NHS Greater Glasgow and Clyde between 2017 and 2018 revealed 16 280 results. A further search for patients with two ALP <36 separated by 30 days or more ...

Introduction: Many endocrinopathies such as acromegaly, Cushing’s syndrome (CS), pheomochromocytom and lipodystrophia can be associated with insülin resistance and unregulated diabetes mellitus (DM).Case report: A 37 –year- and 2 months pregnant women admitted to our out patient clinic for regulation of hyperglycemia. On physical examination; Blood Pressure: 140/95 mmHg, Body Mass Index: 31 kg/m2, central obesity, acanthosis nig...

Sweet syndrome is a febrile dermatosis characterized by painful light red patches of quite different size involving various skin zones associated with flu like symptoms, arthralgias and rarely frank arthritis. Originally considered rare, over 500 cases in the past 10 years have been described. The etiology of Sweet’s syndrome is unknown, but a type of hypersensitivity reaction leading to stimulation of a cascade of cytokines has been strongly suggested. In very few cases ...

Prolactin (PRL) exists in different forms in human serum. The predominant form is little PRL (23 kDa) with smaller amounts of big PRL (50–60 kDa), that may be also associated with big big PRL (bbPRL) or macroprolactin (150–170 kDa). A lower biological activity in vivo of bbPRL was reported. Aim of the study was to evaluate the clinical impact of macroprolactin and the association between macroprolactinaemia and polycystic ovary syndrome (PCOS). A group of 115 ...

The metabolism of glucocorticoids within adipose tissue, by the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11HSD1), is known to be altered in obesity and following high fat feeding. Until recently, little attention has been paid to the fat depots found directly adjacent to blood vessels. Emerging evidence suggests that perivascular adipose may play a key role in modulating vascular function. The presence of steroidogenic enzymes within perivascular adipose, and the eff...