Searchable abstracts of presentations at key conferences in endocrinology

ea0022oc2.5 | Thyroid | ECE2010

Thyroid dysfunction related abnormalities in adiponectin and glucose metabolism before and after treatment

Ozdemir Didem , Dagdelen Selcuk , Usman Aydan

Objective: Thyroid dysfunctions have various effects on glucose and lipid metabolism. Adiponectin (ADP) is an adipokine decreased in obesity and insulin resistance. In this study, we aimed to investigate the role for ADP in thyroid dysfunction related changes in glucose and lipid metabolism.Methods: Newly diagnosed overt hypothyroid (n=20) and thyrotoxic (n=23) adult patients with a body mass index (BMI)<30 kg/m2 were include...

ea0026p444 | Thyroid (non cancer) | ECE2011

Regulation of visceral adipose tissue-derived serin protease inhibitor in overt and subclinical hypothyroid patients

Cinar Nese , Gulcelik Nese Ersoz , Aydin Kadriye , Akin Safak , Usman Aydan , Gurlek Alper

Introduction: Visceral adipose tissue-derived serine protease inhibitor (vaspin) is a novel adipocytokine which might exert an insulin-sensitizing effect. It is thought that vaspin mRNA expression may be a compensatory mechanism associated with obesity and insulin resistance. Given the fact that subclinical and overt hypothyroidism are known risk factors for insulin resistance, we aimed to assess the regulation of vaspin by thyroid hormones in humans.Met...

ea0022p351 | Diabetes | ECE2010

Increased serum nesfatin-1 levels in patients with impaired glucose tolerance

Gulcelik Nese Ersoz , Akin Safak Cavus , Aksoy Duygu Yazgan , Karakaya Jale , Usman Aydan

Objective: Nesfatin was found to be co-localized with insulin in pancreatic β cells and its levels were decreased in type 2 diabetic patients. In order to investigate the role of nesfatin in carbohydrate metabolism, we measured baseline nesfatin-1 levels and its response to glucose load in patients with impaired glucose tolerance (IGT) and in healthy subjects.Subjects and methods: Fourteen patients with IGT and, 13 age and body mass index matched co...

ea0022p810 | Thyroid | ECE2010

Atorvastatin inhibited proliferation in papillary thyroid cancer cell line

Gulcelik Nese Ersoz , Zeybek Dilara , Kaymaz Figen , Sarisozen Can , Asan Esin , Vural Imran , Usman Aydan

Aim: The role of statins on thyroid cell proliferation is of clinical interest. In this study, we investigated the effect of atorvastatin on papillary thyroid cell line (B-CPAP) and normal thyroid (Nthy-ori3-1) cell lines.Materials and methods: In this in vitro study, B-CPAP and Nthy-ori3-1 cell lines were treated with atorvastatin at 12.5, 25, 50, 100, 200 μM concentrations. At 48 and 72 h MTT, electron microscopy and immunohistochemistry we...

ea0022p843 | Thyroid | ECE2010

Effects of L-thyroxine treatment on resistin and high-sensitive CRP levels in patients with subclinical hypothyroidism

Aksoy Duygu Yazgan , Harmanci Ayla , Cinar Nese , Yildiz Bulent Okan , Usman Aydan , Bayraktar Miyase

Background: Subclinical hypothyroidism (SH) is an endocrine disorder defined by increased thyrotropin (TSH) levels associated with normal free thyroxine (fT4) and free triiodothyronine (fT3). Resistin is secreted from the adipose tissue and is reported to be associated with insulin resistance and/or inflammation. High-sensitive CRP (hs-CRP) is a reliable marker of inflammation. Data related to levels of resistin and hS-CRP in SH is limited.<p class="a...

ea0073oc10.1 | Oral Communications 10: Thyroid | ECE2021

The role of VEGF expression in the development of papillary thyroid carcinoma in patients with lymphocytic thyroiditis

Gulcelik Nese Ersoz , Akın Şafak , Aydin Kadriye , Aydin Mericö Cisel , Usman Aydan

BackgroundVascular endothelial growth factor (VEGF) has been implicated in angiogenesis of papillary thyroid carcinoma (PTC). As VEGF expression is increased in PTC and even in lymphocytic thyroiditis (LT), we hypothesized that VEGF may play a role in the development of PTC in patients with LT. In order to find an association between VEGF and these disorders, we examined both the tumoral and adjacent tissues of PTC patients with and without LT.<p cla...

ea0022p707 | Obesity | ECE2010

Complementary and alternative medicine use in patients with obesity: an anthropological approach

Aksoy Duygu Yazgan , Cinar Nese , Levendoglu Fuat , Canikli Yasemin , Yildiz Bulent Okan , Bayraktar Miyase , Usman Aydan , Ilbars Zafer

Introduction: Complementary and alternative medicine (CAM) is a group of diverse medical and health care systems, practices, and products that are not presently considered to be part of conventional medicine. For most of CAM, there are key questions that are yet to be answered through well-designed scientific studies. Obesity is one of the chronic health disorders which is difficult to deal and most of the obese patients are unable to lose or keep weight with diet, exercise or...