Searchable abstracts of presentations at key conferences in endocrinology

ea0016p803 | Thyroid | ECE2008

Thyroid peroxidase antibodies and levels of thyroid stimulating hormone as predictors of development of hypothyroidism in euthyroid subjects

Roos Annemieke , Links Thera , Jong-van den Berg Lolkje de , Gans Rijk , Wolffenbuttel Bruce , Bakker Stephan

Introduction: Presence of thyroid peroxidase antibodies (TPOAbs) may be a marker of future thyroid failure. However, prospective studies in a euthyroid population have not been performed.Aim of the study: To prospectively investigate the relationship between presence and levels of TPOAbs and incident hypothyroidism in euthyroid subjects in the general population.Study population: The database used for this study consisted of a rand...

ea0067o57 | Oral Presentations | EYES2019

βeta-hydroxybutyrate and risk for incident type 2 diabetes: results from the prevend prospective cohort study

Flores-Guerrero Jose L , Connelly Margery A , Groothof Dion , Gruppen Eke G , Bakker Stephan JL , Dullaart Robin PF

Objective: A potential role for the ketone body beta-hydroxybutyrate (β-OHB) has received increasing interest in the study of metabolic disease, but the association of β-OHB with Type 2 Diabetes (T2D) risk remains unclear. The present study aimed to explore the association of β-OHB with incident T2D in a prospective population-based cohort.Methods: We measured plasma concentrations of β-OHB using nuclear magnetic resonance spectroscop...

ea0073oc7.1 | Oral Communications 7: Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Circulating concentrations of TMAO is associated with all-cause mortality in subjects with Non-alcoholic fatty liver disease. Results from a dutch prospective cohort

Flores-Guerrero Jose L. , van Dijk Peter R. , Connelly Margery A. , Garcia Erwin , Navis Gerjan , Bakker Stephan J.L. , Dullaart Robin P.F.

ObjectiveDue to the increasing prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD), it has become a global health challenge by being the most common cause of chronic liver disease. Recently, the microbiota has been linked to NAFLD, via altered bile acid and lipid metabolism. Whether serum Trimethylamine-N-oxide (TMAO), a gut microbiota-dependent metabolite, is associated with NAFLD and NAFLD health outcomes remains unclear. The aim was to investigate...

ea0084op-06-28 | Oral Session 6: Hypothyroidism | ETA2022

The optimal ranges of thyroid function based on the risk of cardiovascular disease and mortality: an individual participant data meta-analysis

Xu Yanning , Derakhshan Arash , Wildisen Lea , Hysaj Ola , Iacoviello Massimo , Ceresini Graziano , Ferrucci Luigi , Iervasi Giorgio , Pingitore Alessandro , Vaes Bert , Gussekloo Jacobijn , Medici Marco , Galesloot Tessel , P. F. Dullaart Robin , J.L. Bakker Stephan , Wouter Jukema J. , Trompet Stella , Westendorp Rudi , Ittermann Till , Volzke Henry , Dorr Marcus , Schmidt Borge , Fuhrer Dagmar , J. Wareham Nicholas , Boelaert Kristien , Razvi Salman , P. J. Vanderpump Mark , Muendlein Axel , Drexel Heinz , Bensenor Isabela , Sgarbi Jose , C. Bauer Douglas , A. Fink Howard , M. Rhee Connie , Azizi Fereidoun , Imaizumi Misa , B. Yeap Bu , Hankey Graeme , J. Brown Suzanne , P. Walsh John , Korevaar Tim , Rodondi Nicolas , R. Cappola Anne , Peeters Robin , Chaker Layal , the Thyroid Studies Collaboration for

Background and Objective: Thyroid function reference ranges are statistically defined by the 2.5th and 97.5th percentiles, which do not account for potential risk of clinical outcomes. We aimed to define the optimal ranges of thyroid-stimulating hormone (TSH) and free thyroxine (FT4), based on the risk of cardiovascular disease (CVD) and mortality.Methods: We performed an individual-participant data analysis and identified prospecti...